Trastuzumab Induces Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer, Suggesting Repurposing Potential.

Background: Breast cancer remains the most common invasive cancer in women worldwide. Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options. Trastuzumab (Tz) is typically used to treat HER2-positive breast cancers, but its potential in TNBC is unclear.

Marginal bone loss and soft tissue health around two-implant mandibular overdenture retained with milled versus selective laser melted cobalt chromium bar: a randomized clinical trial.

Background: To assess marginal bone loss and soft tissue health around two-implant mandibular overdenture retained with milled versus selective laser-melted cobalt chromium (Co-Cr) bars.

Method: This research was set to be a parallel, triple-blinded, randomised controlled trial. Twenty completely edentulous patients received new conventional complete dentures according to conventional techniques.

Mitigation of water stress in broccoli by soil application of humic acid.

The main challenge to plant productivity is water scarcity, which is predicted to get worse with climate change, particularly in arid and semi-arid areas. Humic acid could improve plant tolerance to mitigate drought damage, which is an effective strategy to improve crop production and agriculture sustainability under limited water conditions in these regions, but its effective application rates should also be established. Thus, two field experiments were carried out at the Qaha Vegetable Research Farm in Qalubia Governorate, Egypt, during the two seasons of 2020-21 and 2021-22 on clay soil.

Effect of water stress and foliar application of chitosan and glycine betaine on lettuce.

The present study investigated the effect of foliar application of chitosan at 150 ppm and glycine betaine at 700 ppm on lettuce plants cv. Balady grown under well-watered and water deficit conditions in terms of growth, yield, quality, and water usage efficiency. The study was conducted in Qalubia Governorate, Egypt, during the two seasons of 2020/2021 and 2021/2022 on clay soil.

Cross section empirical formulation for (n, 2n) nuclear reactions on natural isotopes from Z= 21 to Z= 79 for neutron energy range, 8-20 MeV.

Neutron induced reactions with different target materials and isotopes are very important for completion of nuclear data base as well as for many applications. Since the experimental determinations of the reaction cross sections for such reactions are not always available, attempts were made to introduce empirical or semi empirical formulae. In this work, new empirical formulation for (n, 2n) nuclear reactions on natural isotopes for neutron energies range 8-20 MeV, based on some published experimental works.

New empirical formulae for (n, p) reaction cross sections on stable isotopes from Z= 21 to Z= 51 for energies up to 20 MeV.

Neutron Induced reactions on different target nuclei have get impact on many nuclear basic sciences and applications. Due to the lack of literature available experimental data for many targets, empirical formulae for the (n, p) reactions cross section on different targets and different incident neutron energies are formulated. The formulae are used for calculation of excitation functions for target isotopes having atomic numbers in the range from 21 to 51 and neutron energies from 20 MeV down to respective threshold energy of each reaction.

Central line-related bloodstream infections and microbiological study in an Egyptian Ministry of Health Hospital.

Background: Central line-associated bloodstream infections continue to be one of the most important health problems in ICU.

Objectives: To identify the central line-related bloodstream infections and their microbiological characteristics Specific objectives to the identify the incidence, predisposing factors of central line-related bloodstream Infections and study the antibiotic sensitivity patterns of the isolated organisms.

Material And Methods: Patients' demographic, clinical data, central venous catheter related data,and blood culture specimen collection data were collected utilizing a descriptive exploratory design from a purposive sample of 120 ICU patients underwent insertion central venous catheter.

Experimental investigation and theoretical evaluation of proton induced nuclear reactions on nickel.

The cross-sections for proton-induced nuclear reactions on natural nickel were experimentally measured for the Ni(p,x)Cu, Ni(p,x)Co and Ni(p,x)Ni reactions from their respective thresholds up to 17 MeV proton energy. The stacked-foil technique in combination with HPGe γ-ray spectroscopy was used. Three codes were used in the theoretical calculations namely ALICE-IPPE, EMPIRE-3.

Excitation functions and yield measurements for Proton Induced Reactions in Stainless Steel: Special relevance to Proton Activation Analysis.

In this work, the excitation functions for protons induced nuclear reactions with stainless steel's constituent elements were measured and the results were used in Proton Activation Analysis (PAA) of 18/10 steel samples which was carried out at Egyptian MGC-20 cyclotron. The elemental concentrations were also checked using the EDX technique. The reactions Fe(p,x)Co, Ni(p,α)Co and Cr(p,x)Mn were studied from threshold up to 14.

Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights.

Background: The intensive care unit (ICU) is a center of multidrug-resistant (MDR) pathogens. This is due to overuse of antibiotics in the treatment of critically ill patients. Tigecycline is a broad-spectrum antibiotic that belongs to the glycylcycline group.

Radiological impact of natural radioactivity in Egyptian phosphate rocks, phosphogypsum and phosphate fertilizers.

In this study, the activity concentrations of the natural radionuclides in phosphate rocks and its products were measured using a high- purity germanium detector (HPGe). The obtained activity results show remarkable wide variation in the radioactive contents for the different phosphate samples. The average activity concentration of U, U, Ra, Th and K was found as (45, 1031, 786, 85 and 765Bq/kg) for phosphate rocks, (28, 1234, 457, 123 and 819Bq/kg) for phosphate fertilizers, (47, 663, 550, 79 and 870Bq/kg) for phosphogypsum and (25, 543, 409, 54 and 897Bq/kg) for single super phosphate respectively.

Determination of concentrations of Fe, Mg, and Zn in some ferrite samples using neutron activation analysis and X-ray fluorescence techniques.

Mg-Zn ferrite is considered as one of the important materials with potential uses in many applications. In this work, samples of ferrite MgZnFeO (where x=0.0, 0.

Evaluation of radiation hazard potential of TENORM waste from oil and natural gas production.

In this study, a potential radiation hazard from TENORM sludge wastes generated during exploration and extraction processes of oil and gas was evaluated. The activity concentration of natural radionuclides (238)U, (226)Ra and (232)Th were determined in TENORM sludge waste. It was found that sludge waste from oil and gas industry is one of the major sources of (226)Ra in the environment.

The role of single immediate loading implant in long Class IV Kennedy mandibular partial denture.

Background: The treatment of long-span Kennedy class IV considers a prosthodontic challenge. This study evaluated the integrity of principle abutments in long Kennedy class IV clinically and radiographically, when rehabilitated with conventional metallic partial denture as a control group and mandibular partial overdentures supported with single immediately loaded implant in symphyseal as a study group.

Material And Methods: Twelve male patients were divided randomly allotted into two equal groups.