Soluble urokinase-type plasminogen activator receptor as a measure of treatment response in acute exacerbation of COPD.

Objective: To evaluate the value of soluble urokinase-type plasminogen activator receptor (suPAR) in the diagnosis of acute exacerbation of COPD (AECOPD) and in monitoring treatment response, analyzing the relationship between suPAR and fibrinogen in AECOPD. AECOPD leads to increased airway inflammation, contributing to an exaggerated release of inflammatory mediators.

Methods: We recruited 45 patients with AECOPD and 20 healthy control subjects.