Interplay between activity, elasticity, and liquid transport in self-contractile biopolymer gels.

Active gels play an important role in biology and in inspiring biomimetic active materials, due to their ability to change shape, size, and create their own morphology. We study a particular class of active gels, generated by polymerizing actin in the presence of cross-linkers and clusters of myosin as molecular motors, which exhibit large contractions. The relevant mechanics for these highly swollen gels is the result of the interplay between activity and liquid flow: gel activity yields a structural reorganization of the gel network and produces a flow of liquid that eventually exits from the gel boundary.

Self-assembled active actomyosin gels spontaneously curve and wrinkle similar to biological cells and tissues.

Living systems adopt a diversity of curved and highly dynamic shapes. These diverse morphologies appear on many length scales, from cells to tissues and organismal scales. The common driving force for these dynamic shape changes are contractile stresses generated by myosin motors in the cell cytoskeleton, that converts chemical energy into mechanical work.

The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton.

Cells can actively change their shapes and become motile, a property that depends on their ability to actively reorganize their internal structure. This feature is attributed to the mechanical and dynamic properties of the cell cytoskeleton, notably, the actomyosin cytoskeleton, which is an active gel of polar actin filaments, myosin motors, and accessory proteins that exhibit intrinsic contraction properties. The usually accepted view is that the cytoskeleton behaves as a viscoelastic material.