Exploring the potential of : isolation, characterization, and pharmacological evaluation of its anti-diabetic properties.

We isolated two phytoconstituents using bioassay guided isolation for anti-diabetic property from the hydroalcoholic extract of (Colsm.) Pennell (Family: Linderniaceae). We assessed the anti-diabetic potential using various assays, including the glucose absorption assay, glucose uptake in isolated rat abdominal muscle assay, insulin secretion by RIN-5F cells assay, α-amylase inhibition activity, and DPP-4 inhibition assay.

Polysorbate 80-coated albumin nanoparticles to deliver paclitaxel into the brain to treat glioma.

To develop stable paclitaxel (PTX)-loaded bovine serum albumin (BSA) nanoparticles (BSA-NPs-PTX) as drug-delivery vehicles for delivering paclitaxel into the brain to treat glioma. This study used PTX-loaded BSA NPs coated with polysorbate 80 (Ps 80) to enhance PTX concentration in the brain. The low IC indicated that the fabricated BSA-NPs-PTX and BSA-NPs-PTX-Ps 80 showed significantly enhanced cytotoxicity.

Lipid nanoparticles in the development of mRNA vaccines for COVID-19.

Coronavirus disease (COVID-19) was first reported in December 2019, Hubei Province, China. As on 9th December 2021, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has affected 266018810 people worldwide with 5265092 deaths. The outbreak of COVID-19 pandemic has caused severe public health crisis across the world.

Neuroprotective effect of against monosodium glutamate-induced excitotoxicity.

We aimed to evaluate the neuroprotective effect of against monosodium-glutamate (MSG) induced excitoneurotoxicity in rats. We randomly divided the animals into 11 groups ( = 8) and subjected them to high doses of MSG (2 g/kg body weight) and the test dose (1 week). The test chemicals were extracts of petroleum ether, chloroform, methanol, and water.

Neurotherapeutic applications of nanomedicine for treating Alzheimer's disease.

Alzheimer's disease (AD) is a progressive, irreversible, fatal brain disease which disturbs cognitive functions. It affects 35 million people worldwide and the number of people suffering may increase to 100 million by 2050 if no effective treatments are available. The present treatment improves cognitive functions and provide temporary symptomatic relief, but do not stop or delay the disease progression.