Publications by authors named "Geetha Balakrishnan Sreedevi"
Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways.
Arakkaveettil Kabeer Farha Sethumadhavannair Rajalekshmi Dhanya Sivasankaran Nair Mangalam Balakrishnan Sreedevi Geetha Panickamparambil Gopalakrishnan Latha
Cell Biol Toxicol
December 2014
Article Synopsis
- * The study identified that apoptosis was linked to the activation of various caspases and the production of reactive oxygen species, along with changes in key proteins related to cell survival and death.
- * Additionally, treatment with deoxyelephantopin resulted in G2/M phase cell cycle arrest, influenced by signaling pathways like STAT3/p53/p21 and MAPK, highlighting its complex role in cancer cell regulation.
Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells.
Farha Arakkaveettil Kabeer Geetha Balakrishnan Sreedevi Mangalam Sivasankaran Nair Dhanya Sethumadhavannair Rajalekshmi Latha Panickaparambil Gopalakrishnan
Chin Med
August 2014
Background: Isodeoxyelephantopin (IDOE) isolated from Elephantopus scaber L. (Didancao) is used in Chinese medicine for the treatment of some types of cancer. The anti-cancer mechanism of IDOE remains unclear.
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