Managing osteoarthritis in primary care: exploring healthcare professionals' views on a multiple-joint intervention designed to facilitate self-management.

Aim: Osteoarthritis (OA) is one of the most common musculoskeletal conditions and a major cause of chronic pain and disability. Self-management of OA through education and exercise are recommended as core treatments. Current research has demonstrated the effectiveness of these approaches, but most trials tailor interventions for specific joints.

Prevalence and seasonal variation in ixodid ticks on cattle of Mathura district, Uttar Pradesh.

Considering the economic impact of various ticks species on livestock, the present study was conducted for epidemiological characterize of common ticks infesting Indian zebu cattle between July 2010 and June 2011 period at various locations of Mathura region of India. A total of 2,515 zebu cattle were examined on random basis throughout the year. The overall prevalence of ticks infestation in cattle was 60.

Compressed matrix dual-component vaginal drug delivery system containing metoclopramide hydrochloride.

The purpose of the present investigation was to produce a quick/slow biphasic delivery system for metoclopramide hydrochloride using the superdisintegrant Ac-di-sol for the fast release layer and hydroxypropyl methylcellulose K100M and Ucarflock 302 to modulate the release of the drug. A dual component tablet made up of a sustained release and an immediate release layer was prepared by direct compression. A 3(2) full factorial design was applied to systematically optimize the drug release profile of the sustained release layer.

Design and in vitro evaluation of a novel vaginal drug delivery system based on gelucire.

Carbamazepine indicated for the control of epilepsy, undergoes extensive hepatic first-pass metabolism after oral administration. A vaginal dosage form of carbamazepine is not commercially available. Conventional suppository having poor retention in the vaginal tract, as they are removed in a short time by the tract's self-cleansing action, having poor patient compliance.

The Kirby-Desai Scale: A Proposed Scale to Assess Tattoo-removal Treatments.

Background: As tattoos have become increasingly popular in the Western world, tattoo-removal requests have also increased, as patients' personal identities advance. Laser tattoo removal is the current treatment of choice given its safety and efficacy. However, due to varying types of tattoos, it has been difficult to quantify the number of laser treatments required with certainty when discussing laser tattoo removal with our patients.

Low concentrations of commercial alcohol hand rubs facilitate growth of and secretion of extracellular proteins by multidrug-resistant strains of Acinetobacter baumannii.

Acinetobacter baumannii is increasingly recognized as an important multidrug-resistant nosocomial pathogen. Recent work has highlighted enhanced growth and heightened virulence in the presence of ethyl alcohols. As alcohol-based hand rubs (ABHRs) are extensively used in health care settings, the authors set out to determine whether the hand rubs could also influence the growth of prevalent multidrug-resistant strains circulating in UK hospitals.

Partner change and perinatal outcomes: a systematic review.

Epidemiological studies suggest that partner change may affect perinatal outcomes in subsequent pregnancies. We conducted a systematic review on the association between paternity change and perinatal outcomes. We searched the literature in MEDLINE using keywords 'paternity', 'partner', 'pre-eclampsia', 'preterm birth', 'low birth weight', and 'birth defects' from 1966 to 2005.

Nanorobot: a versatile tool in nanomedicine.

Miniaturizing in chip technology, optics, micro mechanics, medicine, gene and biotechnology requires highly precise positioning techniques. The motivation for the new manipulation technology is the desire to enter the micro- and nanoworld not only by viewing but also acting, altering micro- and nanosized objects. A new era on medicine are expected to happen in the coming years.

Ethanol promotes T cell apoptosis through the mitochondrial pathway.

Clinical reports suggest that acute ethanol intoxication is often associated with lymphopenia. Previously, ethanol was reported to invoke thymocyte apoptosis. We studied the effect of ethanol on T cell apoptosis.

HIV-1 gp120-induced tubular epithelial cell apoptosis is mediated through p38-MAPK phosphorylation.

Background: HIV-associated nephropathy is accompanied by significant tubular alterations in the form of tubular cell proliferation, apoptosis, and microcystic dilatation. In the present study we evaluated the role of CD4 receptors in HIV-1-induced tubular cell injury.

Methods: To confirm the presence of CD4 receptors in tubular cells, immunocytochemical, Western and Northern blot studies were carried out.