Ocular surface squamous neoplasia - Review of etio-pathogenesis and an update on clinico-pathological diagnosis.

Ocular surface squamous neoplasia (OSSN) has a varied clinical presentation, the diagnosis of which rests on the histopathological examination of the excised lesion. The term OSSN includes mild dysplasia on one end of the spectrum and invasive squamous cell carcinoma on the other end. This lesion has a multi factorial aetiology with interplay of several factors like exposure to ultraviolet radiation, various chemical carcinogens and viral infections, however role of individual agents is not well understood.

Rapid intraoperative diagnosis of tumors of the eye and orbit by squash and imprint cytology.

Purpose: To evaluate the diagnostic accuracy of intraoperative squash and imprint cytologic techniques in ocular and orbital lesions.

Design: Observational case series.

Methods: Forty-five consecutive ocular and orbital biopsy specimens subjected to squash and imprint cytologic techniques for rapid intraoperative diagnosis were included in this study.

Successful reconstruction of damaged ocular outer surface in humans using limbal and conjuctival stem cell culture methods.

When the ocular outer surface is badly damaged, subsequent corneal transplantation fails due to the absence of basal cells that are needed to support the graft. With the realization that the limbus and the conjunctiva have adult stem cells that can be cultured, it has been possible for us to explant culture these on de-epithelized human amniotic membrane, and to graft the resulting viable and transparent epithelium to 125 needy human patients with success. Ultrastructural, histological, biochemical and immunological assays establish the identity of the cells and the tissue formed.

Late orbital recurrence of a choroidal melanoma following internal resection: report of a case and review of the literature.

The management of uveal melanomas always has been a challenge to the clinicians and has evolved from the era of eye-removing surgeries to elimination of the tumor by the body's own immune system through vaccines. Evaluating the outcome of each strategy improves our understanding of the disease process and helps us to improvise on the existing modalities of treatment. Internal resection of choroidal melanomas has been described as one of the treatment modalities for this malignant tumor.

Evaluation of agent and host factors in progression of mycotic keratitis: A histologic and microbiologic study of 167 corneal buttons.

Purpose: To evaluate the host and agent factors in the progression of mycotic keratitis through the microbiologic evaluation and histologic study of human corneal buttons obtained at the time of therapeutic keratoplasty.

Design: Retrospective noncomparative consecutive case series.

Materials: One hundred sixty-seven corneal buttons from 148 patients of microbiologically diagnosed and treated cases of mycotic keratitis who underwent therapeutic keratoplasty between January 1995 and May 1998.

Subepithelial amyloid deposits in congenital hereditary endothelial dystrophy: a histopathologic study of five cases.

Purpose: To report the clinical, histologic, ultrastructural, and immunohistochemical features of congenital hereditary endothelial dystrophy (CHED) associated with subepithelial amyloid deposits.

Methods: The clinical features of seven patients and histologic characteristics of eight corneal buttons were evaluated. The corneal specimens included five cases with histologic features of CHED associated with subepithelial amyloid.

Ectopic brain presenting as orbital and conjunctival mass: A case report.

The presence of brain tissue in the orbit is a rare finding, whether it occurs isolated, in continuity with intracranial contents, or within a tumor. In this paper, the authors report a rare case of ectopic brain in the orbit, presenting as a conjunctival mass, in a 15-day-old female child. The clinical and histological features of the case are presented, together with a review of the literature.