Publications by authors named "Geert W'T Jong"
Objective: Mood and anxiety disorders (MADs) are common conditions with multiple aetiologies. Exposure to antibiotics has been proposed as a possible risk factor in animal studies. We aimed to assess maternal antibiotic use in pregnancy and child antibiotic use in the first three years of life, collectively called early life, as potential risk factors for subsequent development of MADs during childhood and adolescence.
View Article and Find Full Text PDFData from clinical trials are needed to guide the safe and effective use of medicines in children. Clinical trials are challenging to design and implement in all populations, and children present additional considerations. Several regions including the UK, USA and Europe have established clinical trial infrastructure to capitalise on expertise and promote clinical trials enrolling children.
View Article and Find Full Text PDFObjective: Although anti-Saccharomyces cerevisiae antibodies (ASCAs) could be a useful biomarker in differentiating Crohn disease (CD) from ulcerative colitis (UC), their role as prognostic markers in children with CD has been underinvestigated. This longitudinal prospective observational study aimed to assess the prognostic value of ASCA status among children with CD managed using biologics.
Methods: The study population comprised children with inflammatory bowel disease diagnosed with CD from 2012 to 2018.
Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis.
J Basic Clin Physiol Pharmacol
October 2018
Article Synopsis
- Wernicke-Korsakoff syndrome (WKS) includes Wernicke encephalopathy and Korsakoff psychosis, both linked to thiamine deficiency, which affects the body's ability to utilize carbohydrates.
- Thiamine deficiency can arise from genetic factors or conditions like alcoholism and often leads to symptoms that are similar to other neurological disorders, making WKS difficult to diagnose.
- Timely diagnosis and treatment of Wernicke encephalopathy are crucial to prevent the severe memory loss associated with Korsakoff psychosis, and this review highlights research on the causes, identification, and treatment options for these conditions.
Objective: Conduct of clinical trials is perceived to be more challenging in children than in adults. This study aimed to evaluate the impact of the age of participants on completion rates of randomized controlled trials (RCTs).
Study Design And Setting: A cross-sectional study on RCTs registered in the ClinicalTrials.
Background: Systemic corticosteroids as the frontline treatment of respiratory distress syndrome (RDS) in preterm infants are associated with adverse effects on growth and neurodevelopmental outcome, but the pulmonary administration of steroids may help prevent the development of bronchopulmonary dysplasia (BPD) without these side effects.
Objectives: To evaluate the efficacy and safety of pulmonary application of corticosteroids in preterm infants with RDS.
Methods: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.
Introduction: Antibiotics are the most commonly prescribed drug class in children. Real-world data mining on the paediatric population showed potential associations between antibiotic use and acute liver injury.
Objective: We assessed risk estimates of liver injury associated with antibiotic use in children and adolescent outpatients.
Non-alcoholic fatty liver (NAFL) disease (NAFLD) affects 30% of overweight adolescents and increases the risk of type 2 diabetes mellitus (T2D). Resveratrol is a naturally occurring compound with potential to reverse NAFL and its associated insulin resistance in adults. The use of resveratrol to reduce risk for T2D through its effect on NAFL has not been examined to date in youth.
View Article and Find Full Text PDFObjective: To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a non-serious adverse drug reaction (ADR).
Design: Cohort study.
Setting: A healthcare database containing the electronic GP medical records of over 1.
Aims: Low-dose aspirin (LDA) and non-steroidal-anti-inflammatory drugs (NSAIDs) both increase the risk of upper gastrointestinal events (UGIEs). In the Netherlands, recommendations regarding the prescription of gastroprotective agents (GPAs) in LDA users were first issued in 2009 in the HARM-Wrestling consensus. National guidelines on gastroprotective strategies (GPSs) in NSAID users were issued in the first part of the preceding.
View Article and Find Full Text PDFObjective: To determine the influence of ischaemic cardiovascular (CV) risk on prescription of non-steroidal anti-inflammatory drugs (NSAIDs) by general practitioners (GPs) in patients with musculoskeletal complaints.
Design: Cohort study.
Setting: A healthcare database containing the electronic GP medical records of over one million patients throughout the Netherlands.
Background: The use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with serious adverse drug events (ADEs).
Aim: To determine the prevalence of over-the-counter (OTC) NSAID use in the general population and in patients with a high risk of developing a serious NSAID-related ADE.
Design And Setting: Cross-sectional study in four general practices in the Netherlands.
Objective: The Dutch HARM-Wrestling (HW) Task Force issued general and drug-specific recommendations aimed at reducing hospital admissions related to medication (HARMs). This study examines if the drug-specific recommendations could be converted into indicators that could be monitored in existing databases of general practitioner (GP) or community pharmacy (CP) data. The study also assesses the performance of these indicators before and during the official release of HW recommendations.
View Article and Find Full Text PDFBackground: Data on utilization patterns and safety of non-steroidal anti-inflammatory drugs (NSAIDs) in children are scarce. The purpose of this study was to investigate the utilization of NSAIDs among children in four European countries as part of the Safety Of non-Steroidal anti-inflammatory drugs (SOS) project.
Methods: We used longitudinal patient data from seven databases (GePaRD, IPCI, OSSIFF, Pedianet, PHARMO, SISR, and THIN) to calculate prevalence rates of NSAID use among children (0-18 years of age) from Germany, Italy, Netherlands, and United Kingdom.
Background: Acute liver failure is idiopathic and drug-related in, respectively, around 50 and 15 % of children. Population-based, epidemiologic data about the pattern of disease manifestation and incidence of less severe acute liver injury, either idiopathic or potentially drug-attributed are limited in children and adolescents.
Objectives: (i) To assess the incidence of idiopathic acute liver injury (ALI) and its clinical features in children and adolescent outpatients; and (ii) to investigate the role of the drug as a potential cause of ALI which is considered idiopathic.
A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms.
View Article and Find Full Text PDFObjective: To investigate the incidence and characteristics of hospital admissions related to adverse drug events in the paediatric setting.
Design: Prospective single-centre study.
Setting: A secondary and tertiary paediatric care centre.