Publications by authors named "Geert Lefeber"

Article Synopsis
  • The study evaluated frailty and other impairments in patients being considered for left ventricular assist devices (LVAD) or heart transplants (HTx) using a comprehensive geriatric assessment (CGA).
  • A total of 73 patients aged 40 and older were assessed, revealing that 97% had at least one impairment, with common issues including polypharmacy, reduced functionality, and depression.
  • The findings indicate that most candidates have multiple impairments, which could influence decisions about their eligibility for LVAD or HTx.
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Background: Studies have found statin treatment to be associated with improved 1-year survival after transcatheter aortic valve implantation (TAVI), suggesting pleiotropic effects of statins on preventing perioperative complications. Statin treatment is not associated with postoperative cardiovascular complications or mortality; however, other postoperative complications have not been investigated.

Aim: To explore whether preoperative statin treatment is associated with a lower short-term risk of mortality, readmission and major postoperative complications in older patients undergoing TAVI.

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Objective: In recent years, transcatheter aortic valve implantation (TAVI) has become the treatment of choice for patients with symptomatic aortic valve stenosis considered to be at increased or high surgical risk. The aim of this study was to identify predictors of postoperative adverse events in older adults undergoing TAVI.

Methods: A prospective observational cohort study of patients who were referred to a geriatric outpatient clinic for a geriatric assessment prior to TAVI was conducted.

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Objective: To explore the effect of initiating statins for secondary prevention after a first myocardial infarction (MI) in patients aged 80 years and older.

Design: Retrospective cohort study.

Setting: Clinical Practice Research Datalink (1999-2016).

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Background: Haloperidol, frequently used for delirium, can lead to serious side effects, of which QTc prolongation is the most worrisome since it is associated with an increased risk of fatal cardiac arrhythmia.

Objectives: The aim of this study was to measure the frequency of haloperidol use after procedures in patients aged ≥65 years in a hospital in the Netherlands.

Methods: This was a retrospective study among patients hospitalized in the Netherlands who were aged ≥65 years and who underwent a procedure between January 2008 and January 2009.

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