Publications by authors named "Geert J A Sevink"
The membrane-protein interface on lipid-based nanoparticles influences their in vivo behavior. Better understanding may evolve current drug delivery methods toward effective targeted nanomedicine. Previously, the cell-selective accumulation of a liposome formulation in vivo is demonstrated, through the recognition of lipid phase-separation by triglyceride lipases.
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- - The study focuses on enhancing drug delivery in nanomedicine by using a synthetic lipidated peptide pair, E4/K4, that promotes membrane fusion to improve therapeutic efficacy.
- - To achieve better fusion, dimeric variants of peptide K4 are created, and their interactions with E4-modified liposomes and cells are analyzed for their structural and functional properties.
- - The research shows that the specific coiled-coil interactions of the parallel PK4 dimer significantly improve drug delivery efficiency, as demonstrated with doxorubicin, highlighting a promising method for targeted drug therapies.
External electric fields align nanostructured block copolymers by either rotation of grains or nucleation and growth depending on how strongly the chemically distinct block copolymer components are segregated. In close vicinity to the order-disorder transition, theory and simulations suggest a third mechanism: selective disordering. We present a time-resolved small-angle X-ray scattering study that demonstrates how an electric field can indeed selectively disintegrate ill-aligned lamellae in a lyotropic block copolymer solution, while lamellae with interfaces oriented parallel to the applied field prevail.
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