BMI and Deescalation From Ticagrelor to Clopidogrel in Patients With Acute Myocardial Infarction: A Post Hoc Analysis of the TALOS-AMI Trial.

Importance: The potential benefits of P2Y12 inhibitor deescalation for acute myocardial infarction after percutaneous coronary intervention may be influenced by body mass index (BMI).

Objectives: To investigate the association of BMI on deescalation outcomes after 12 months in patients with acute myocardial infarction after percutaneous coronary intervention who were initially treated with aspirin plus ticagrelor for 1 month, and to assess whether BMI-based switching from aspirin plus ticagrelor (active control strategy) to aspirin plus clopidogrel (deescalation strategy) is associated with individualized benefits.

Design, Setting, And Participants: This study is a post hoc analysis, based on BMI, of data from the TALOS-AMI (Ticagrelor vs Clopidogrel in Stabilized Patients with Acute Myocardial Infarction) randomized clinical trial.

Draft genome sequences of five glacial fungi from Styx Glacier, Antarctica.

We generated four high-quality draft genomes of fungi isolated from Styx Glacier, Antarctica. The genome announcement of these fungal strains offers insights into their evolution and adaptation to extreme glacial environments, as well as their potential biotechnological applications.

Rho-dependent termination and RNase E-mediated cleavage: dual pathways for RNA 3' end processing in polycistronic mRNA.

"Pre-full-length" transcripts are produced at the end of the polycistronic galactose () operon, 5' , via Rho-dependent transcription termination (RDT) and -independent transcription termination. The 3' end of the full-length mRNA is acquired by exonucleolytic processing of the 3'-OH ends of the pre-full-length transcripts. However, the operon produces an mRNA termed whose 3' end forms approximately 120 nucleotides downstream of the stop codon, within the subsequent gene, , thereby establishing polarity in gene expression.

Oral contraceptive pill phase does not influence muscle protein synthesis or myofibrillar proteolysis at rest or in response to resistance exercise.

There is speculation that the use of oral contraceptive pill (OCP) affects skeletal muscle biology and protein turnover in response to resistance exercise; however, research in this area is scarce. We aimed to assess, using stable isotope tracers and skeletal muscle biopsies, how second-generation OCP phase affected muscle protein synthesis and whole body proteolysis. Participants ( = 12) completed two 6-day study phases in a randomized order: an active pill phase (active; of a monthly active OCP cycle) and an inactive pill phase (inactive; final week of a monthly OCP cycle).

Poly-Victimization Patterns and Their Correlates Among International Asian and Latina Sex Trafficking Survivors in New York City.

International Asian and Latina women who are sex trafficking survivors experience a wide spectrum of gender-based violence throughout their life course and suffer from its adverse mental and physical health outcomes. However, there is limited research among this seldom heard population. This study aims to explore poly-victimization patterns of child abuse, intimate partner violence (IPV), client violence, and police violence; and to explore their associations with psychosocial factors.

Utility of the BeBack re-entry catheter to treat resistant cephalic arch occlusion in a haemodialysis patient: Case report and review of the literature.

Background: Cephalic arch stenosis is a common complication in haemodialysis patients with brachiocephalic arteriovenous fistula (AVF) that can lead to access dysfunction. For resistant lesions that fail conventional endovascular treatment, a possible salvage approach to avoid open surgery is via sharp recanalization using re-entry catheters.

Methods: We describe the unprecedented use of the BeBack re-entry catheter (Bentley InnoMed GmbH), previously the GoBack catheter (Upstream Peripheral Technologies), to overcome a recalcitrant cephalic arch occlusion by sharp recanalization in a 73-year-old female with thrombosed left brachiocephalic AVF that failed revascularization using conventional catheter and wire techniques.

Encoded Display of Chemical Libraries on Nanoparticles as a Versatile Selection Tool To Discover Protein Ligands.

DNA-encoded library (DEL) technology is a powerful tool for discovering potent ligands for biological targets but constrained by limitations, including the insolubility of DNA in organic solvents and its instability under various reaction conditions, which restrict the reactivity scope and structural diversity achievable in library synthesis. Here, we present a new strategy called nanoDEL, where library molecules and DNA tags are displayed on the surface of nanoparticles. Since nanoparticles disperse well in both organic solvents and aqueous solutions, DEL synthesis can be accomplished using well-established organic solvent-based conditions, eliminating the need for aqueous conditions.

Minimally invasive surgical techniques compared to an extensile lateral approach in the management of displaced intra-articular calcaneal fractures. A systematic review and meta-analysis of randomised controlled trials.

Background: Developments in minimally invasive surgical techniques (MIS) have sparked debate over the optimal intervention for calcaneal fractures. This meta-analysis compares the extensile lateral approach (ELA) to two MIS techniques; the sinus tarsi approach and percutaneous approaches.

Methods: A systematic search was conducted across seven databases for randomised control trials (RCTs).

Three strategies of implant placement as an abutment for combined tooth-implant-supported double crown removable partial dentures: A clinical report of three patients up to 18 years.

Double crown removable partial dentures (RPDs) are suitable treatment options for patients with a significantly reduced dentition. The prognosis for these prostheses is greatly influenced by the number, position, and distribution of the abutment teeth. If the remaining natural teeth are unfavorably positioned, placing implants in strategic positions may enhance the long-term prognosis of the prosthesis.

Breaking barriers: Nitric oxide-releasing nanocomplexes for collagen degradation and enhanced αPD-L1 immunotherapy in deep tumor.

Overcoming the physical barrier of the extracellular matrix (ECM) surrounding tumors is a critical challenge in achieving effective immune checkpoint blockade (ICB). The dense ECM impedes the infiltration of immune checkpoint inhibitors (ICIs) and cytotoxic T lymphocytes (CTLs) into tumor tissues. To address this, we design a nanocomplex incorporating a reactive oxygen species (ROS)-responsive nitric oxide (NO) prodrug around TANNylated αPD-L1.

Sex disparity and the uptake of home dialysis following kidney transplant failure.

Introduction: Home dialysis modalities offer several clinical and economic benefits compared to facility-based dialysis treatment in patients with kidney failure. Studies have shown that sex and socioeconomic status (SES) disparities exist in access to dialysis and transplantation in patients with kidney failure, but whether similar disparities occur in the access to home dialysis after kidney transplant failure is unknown.

Methods: Using data from ANZDATA registry, patients who commenced dialysis after kidney transplant failure in Australia were included (2000-2020).

Effect of Nurse Residency Programs on New Graduate Nurses Entering the Critical Care Setting: An Integrative Review.

The transition period from undergraduate nursing education to professional practice is a time of uncertainty and great difficulty for new graduate nurses (NGNs). Nurse residency programs (NRPs) provide structured education, simulation-based learning, and preceptorship to ease the transition. Although its effect on improving retention of NGNs is well established in the literature, the effect on clinical competency has not been documented as well.

Values, principles and research priorities for the implementation of type 2 diabetes prevention after gestational diabetes: A global consensus from Asia, Africa, Americas, Europe and Oceania.

Aims: The implementation of type 2 diabetes prevention after gestational diabetes (GDM) is poor despite research evidence on efficacy. This is limited by the lack of knowledge of the priorities in real-world settings from the perspectives of local clinicians and women with lived experiences, particularly those from underserved populations. We report here a global consensus on the values, principles, and research priorities for the implementation of type 2 diabetes prevention in individuals after gestational diabetes (GDM), from the perspectives of clinicians and women from Asia, Africa, Oceania, the Americas, and Europe.

Work-Related Musculoskeletal Disorders Among Podiatrists in Singapore.

Background: Work-related musculoskeletal disorders have become a leading occupational health problem in healthcare professionals. This study aims to bring attention to a growing problem by reporting the prevalence, risk factors and workplace interventions related to workrelated musculoskeletal disorders in Singapore podiatrists.

Methods: All podiatrists in Singapore were eligible to participate.

Fibroblast-Derived Human iPSC Exhibits Superior Haematopoietic Potential over Human ESC during Haematopoietic Differentiation.

Haematopoietic stem cells (HSC) and macrophages hold promise for cell-based therapy. Induced pluripotent stem cells (iPSC) offer an alternative to human embryonic stem cells (hESC) for generating haematopoietic cells in vitro, sidestepping ethical concerns. However, precise comparisons of the developmental process and productivity between iPSC and hESC during haematopoietic differentiation are limited, and producing sufficient HSC for clinical use remains challenging.

Tracking genetic diversity in amur tigers: a long-term study using microsatellites in Southwest Primorye, Russia.

Background: The tiger population in Southwest Primorye is small and predominantly isolated from the main Sikhote-Alin population, which constitutes approximately 90% of the wild Amur tiger population. By 1996, this population declined to fewer than 10 individuals, but it has since grown and expanded into nearby habitats, now numbering over 50 individuals. Therefore, the regular genetic monitoring of this population is essential, as it has grown from a few founding members and remained geographically isolated.

Occlusion of TCR binding to HLA-A*11:01 by a non-pathogenic human alloantibody.

Over the last decades, organ transplantation has made rapid progress as a curative therapy for organ failure. However, the adaptive immune system-alloreactive T cells and antibodies targeting human leukocyte antigens (HLA)-is the leading cause of graft rejection. The presence of anti-donor HLA antibodies is considered a risk factor that disqualifies a particular donor-recipient pair.

Astrocyte-Specific Phenotyping of FAD as an Alzheimer's Disease Mouse Model.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, characterized by memory decline and behavioral changes. Its pathological features include senile plaques, neurofibrillary tangles, and reactive gliosis, comprising abnormal accumulations of β-amyloid peptide (Aβ) and hyperphosphorylated tau protein surrounded by reactive astrocytes and microglia. Recently, it has emerged that severe reactive astrocytes and MAOB-dependent production of GABA and HO are the real causes of learning and memory impairment and neurodegeneration.

Nonmelting Disordering Facilitated by Electron Delocalization.

Disordering atomic structures offers a functionality hardly expected in ordered states, including phase-change memory and photonic computing, offering the potential to renovate von Neumann architecture for neuromorphic engineering with low latency. However, significant energy consumption during the disordering compromises the data reliability and integration efficiency, which is traditionally regarded to take place after melting. Here, we investigate time for disordering in isochronal and isochoric manners, challenging the conventional melt-quenching theory.

Enhancing Professionalism Online (Netiquette) in Medical Schools: A Systematic Scoping Review.

Background: The relaxing of COVID-19 pandemic restrictions has not seen the return to previous in-person teaching formats. As blended training continues to be used, there is emphasis on the need to better appreciate the expectations, etiquette, and professional code of conduct ("netiquette") surrounding online learning, especially in light of evidence that poor online professionalism compromises learning and clinical practice.

Objectives: This review seeks to map regnant netiquette guidelines in medical schools that will inform and provide preliminary recommendations for a clinically relevant framework.

Migration of Wintering Grey Plover From Southeast Asia to North-Central Siberia Challenges Breeding Population Delineations in Russia.

Shorebird populations are declining across the world due to factors such as habitat loss and climate change. Identification of shorebird migration routes and important stopover sites can facilitate the implementation of strategic and effective conservation measures. Using a satellite transmitter, we successfully tracked the migration of one Grey Plover () from its wintering grounds in Singapore north along the East Asian-Australasian Flyway (EAAF) to its breeding grounds located east of the Taymyr Peninsula in north-central Siberia.

Biosynthesis of Polyhydroxyalkanoates From Sucrose by Recombinant Pseudomonas putida KT2440.

A sucrose-utilization pathway was developed in Pseudomonas putida using sacC from Mannheimia succiniciproducens, which encodes a β-fructofuranosidase that hydrolyzes sucrose into glucose and fructose. Excretion of β-fructofuranosidase into the culture medium was confirmed via western blot analysis. In nitrogen-limited cultivation, P.

Exosome-Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering.

Exosomes have emerged as versatile biomolecules in gastrointestinal (GI) cancer management, leveraging their inherent cargo-carrying capabilities to overcome the limitations of current diagnostic and therapeutic strategies. This review provides a comprehensive exploration of exosome-based technologies, highlighting their dual roles as diagnostic biomarkers and therapeutic vehicles. On the diagnostic front, this review investigates specific exosomal biomarkers-including miRNAs, lncRNAs, circRNAs, and proteins-emphasizing their roles in tumor biology and their clinical utility, such as diagnostic accuracy, early detection potential, and prognostic significance.

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways.

Viruses frequently exploit the host's nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors (NTRs) and nucleoporins within the spiderweb-like inner channel of the nuclear pore complex (NPC), enabling efficient access to the host nucleus. This review explores the intricate mechanisms governing the nuclear import and export of viral components, with a focus on the interplay between viral factors and host determinants that are essential for these processes.