Consensus statement on pain management for pregnant patients with opioid use disorder from the Society for Obstetric Anesthesia and Perinatology, Society for Maternal-Fetal Medicine, and American Society of Regional Anesthesia and Pain Medicine.

Pain management in pregnant and postpartum people with an opioid use disorder requires a balance among the risks associated with opioid tolerance, including withdrawal or return to opioid use, considerations around the social needs of the maternal-infant dyad, and the provision of adequate pain relief for the birth episode that is often characterized as the worst pain a person will experience in their lifetime. This multidisciplinary consensus statement from the Society for Obstetric Anesthesia and Perinatology, the Society for Maternal-Fetal Medicine, and the American Society of Regional Anesthesia and Pain Medicine provides a framework for pain management in obstetrical patients with opioid use disorder. The purpose of this consensus statement is to provide practical and evidence-based recommendations and is targeted to healthcare providers in obstetrics and anesthesiology.

Spousal perceptions and their role in promoting breast cancer screening: a focus group study.

Objectives: To explore husbands' views on breast cancer screening, risk-based screening and their role in influencing their wives' health-seeking behaviours.

Design: Qualitative focus group discussion (FGD) supplemented by quantitative data from a cohort study using a structured questionnaire.

Setting: This study was conducted in a community-based setting, with participants recruited online through non-profit organisations via social media and email.

Risk and Dose-Response Relationship for Pentosan Polysulfate Sodium Maculopathy: A Systematic Review and Meta-Analysis.

Topic: To determine the pooled relative risk (RR) of Pentosan Phosphate Sodium Maculopathy (PPSM) in patients using PPS and model the dose-response relationship of this association from existing literature.

Clinical Relevance: PPSM is an acquired, progressive retinal pigmentary disease associated with oral PPS use. Though several observational studies suggest a dose-response relationship of this association, to-date, there remains no literature-pooled synthesis on risk of PPSM across strata of cumulative dose.

Transfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults An American College of Chest Physicians Clinical Practice Guideline.

Background: Platelets and fresh frozen plasma (FFP) are frequently administered to critically ill patients. Considering the variability in indications and thresholds guiding these transfusions, a comprehensive review of current evidence was conducted to provide guidance to critical care practitioners. This CHEST guideline examined the literature on platelet transfusions in critically ill patients with thrombocytopenia, with and without active bleeding, as well as data on prophylactic platelet and FFP transfusions for common procedures in the critical care setting.

Long COVID-19 in pregnancy: increased risk but modest incidence following mild Omicron infection in a boosted obstetric cohort during endemicity.

Background: Significant heterogeneity has been reported in estimates of long-term sequelae following SARS-CoV-2 infection in pregnant women, and most studies were conducted pre-Omicron and pre-dated vaccination rollout. Less severe COVID-19 attributed to milder Omicron may potentially attenuate risk of post-COVID-19 sequelae.

Objective: We sought to examine long-term risk of new-incident multi-systemic sequelae following SARS-CoV-2 Delta/Omicron infection in a population-based cohort of pregnant women, contrasted against a)test-negatives; b)infected non-pregnant women of childbearing age.

Effect of SMS Ward Round Notifications on Inpatient Experience in Acute Medical Settings: Retrospective Cohort Study.

Background: Ward rounds are an essential component of inpatient care. Patient participation in rounds is increasingly encouraged, despite the occasional complicated circumstances, especially in acute care settings.

Objective: This study aimed to evaluate the effect of real-time ward round notifications using SMS text messaging on the satisfaction of inpatients in an acute medical ward.

Efficacy of Combined CD38 and PD1 Inhibition with Isatuximab and Cemiplimab for Relapsed/Refractory NK/T-Cell Lymphoma.

This study aimed to assess the efficacy and safety of combining cemiplimab, an anti-PD1 antibody, with isatuximab, an anti-CD38 antibody, in relapsed or refractory extranodal NK/T-cell lymphoma (R/R ENKTL). The hypothesis was that CD38 blockade could enhance the antitumor activity of PD1 inhibitors. Eligible patients received cemiplimab (250 mg on days 1 and 15) and isatuximab (10 mg/kg on days 2 and 16) intravenously every four weeks for six cycles.

Silicon/Silica Colloidal Waste in the Semiconductor Industry: Challenges in Recovery and Potential Use.

The backgrinding of silicon (Si) wafers has resulted in a loss of ∼70% of valuable Si materials. Consequently, an effluent known as diluted backgrinding wastewater (DBGW) is generated, containing nanosized silicon/silica colloids. Here, we discussed the challenges associated with the effective separation of Si-based waste from the DBGW based upon two perspectives, namely, a nanosized effect and a colloidal stability effect.

Quantitative detection of the HVEM-BTLA checkpoint receptor cis-complex in human lymphocytes.

The herpesvirus entry mediator (HVEM) (TNFRSF14) engagement of the checkpoint inhibitory receptor B and T lymphocyte attenuator (BTLA) limits immune responses of T and B lymphocytes. HVEM and BTLA form signaling complexes in trans and when coexpressed, complexes in cis, creating a unique immune checkpoint. The function of the HVEM-BTLA cis-complex is not well understood primarily due to a lack of reagents that specifically measure the HVEM-BTLA cis-complex.

Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages.

Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can be highly inflammatory in response to respiratory viruses, they do not mount proinflammatory responses to all airborne pathogens. For example, we previously showed that AMs fail to mount a robust proinflammatory response to Mycobacterium tuberculosis.

Construction of Chitosan Oligosaccharide-Coated Nanostructured Lipid Carriers for the Sustained Release of Strontium Ranelate.

Background: Strontium ranelate (SR) is an effective bone regeneration drug; however, its low bioavailability and strong hydrophilicity cause a strong cytotoxicity, venous thrombosis, and allergic reactions when administered in its free form. This study aims to enhance the SR bioavailability by utilizing nanostructured lipid carriers (NLC) as a drug delivery system (DDS).

Methods: To improve the drug delivery efficiency and sustained release of the NLC, their surfaces were coated with chitosan oligosaccharide (COS), a natural polymer.

Evaluation of industrial air pollution contribution by type of industry in Pasir Gudang using AERMOD.

In industrialized areas, air pollution is a recurring problem, especially in areas with high manufacturing and energy-intensive businesses. The challenge lies in the tension between industrial growth and environmental protection, as these sectors significantly contribute to pollution, resource depletion, and climate change. The objectives of the study were (1) to assess the contribution of each industrial group to the air quality in and around the Pasir Gudang industrial area, Malaysia, and (2) to evaluate the Air Pollution Index (API).

recording and stimulation performance of multi-electrode arrays passivated with plasma-enhanced atomic layer-deposited metal oxides.

To achieve an intimate contact between neuronal cells and the electrode in non-invasive platforms intended for neurological research, in this study, we fabricated a raised-type Au multi-electrode array (MEA) by employing nanoscale-thick indium-tin oxide (ITO; 50 nm) as a track layer and plasma-enhanced atomic layer-deposited (PEALD) AlO (30-60 nm) and HfO (20 nm) as passivation layers. The PEALD AlO-passivated Au MEA was subsequently modified with electrodeposited AuPt nanoparticles (NPs) and IrO to demonstrate the passivation capability and chemical resistance of AlO to Au-, Pt-, and IrO NP-containing electrolytes. AlO-passivated and IrO/AuPt-modified MEAs could resolve optogenetically activated spikes and spontaneous activities with a root-mean-square noise level of 2.

Mendelian randomization analysis of the causal association between metabolite and skin cancer.

Skin cancer (SC) is a significant public health issue, with increasing incidence rates globally. Although environmental factors such as ultraviolet (UV) exposure are recognized risk factors, the impact of metabolites on SC development has not been thoroughly examined. This study seeks to explore the causal association between metabolites and SC risks using a Mendelian randomization (MR) approach.

Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer.

Purpose: Traditional methods, fine-needle aspiration cytology (FNAC) and washout thyroglobulin (Tg), do not always provide sufficient accuracy for diagnosing lymph node (LN) metastasis in thyroid cancer. This study aimed to validate the diagnostic performance of washout cytokeratin fragment 21-1 (CYFRA 21-1) as a complementary biomarker for diagnosing metastatic LNs in thyroid cancer and to explore its relationship with molecular analysis and distant metastasis.

Patients And Methods: In this retrospective cohort study involving 230 LNs in 224 patients with PTC, FNAC, washout Tg, and CYFRA 21-1 levels were measured in suspicious LNs.

Comparison between Phacoemulsification-iStent Inject W and Phacoemulsification-Micropulse Transscleral Laser Therapy in Asian Eyes with Mild-Moderate Open Angle Glaucoma.

Prcis: In this retrospective cohort study, the 1-year cumulative probability of failure was comparable, achieving 52.20% in the phacoemulsification-iStent inject W (phaco/iStent) group and 47.80% in the phacoemulsification-micropulse transscleral laser therapy (phaco/MPTLT) group (P=0.

Fused terthiophene end-capped with barbituric acid as non-fullerene n-type small molecule for an organic photo-detector.

In this work, a new n-type small molecule consisting of a fused thiophene backbone and barbituric acid as the electron-withdrawing group is reported. For green-selective organic photodiodes, when combined with p-type subphthalocyanine, the external quantum efficiency reached 64% at -3 V, owing to suitable absorption properties, efficient charge separation and relatively good transport.

The Prevalence of Tardive Dyskinesia In Patients With Schizophrenia Treated With Antipsychotics In Malaysia.

Background: Tardive dyskinesia (TD) is a movement disorder that is associated with the prolonged use of antipsychotics. The prevalence of TD varies widely from 20% to 50% but often undetected in schizophrenia patients treated with antipsychotics.

Aim: This study is aimed at investigating the prevalence of TD among schizophrenia patients treated with antipsychotics and identifying the associated factors.

Polycaprolactone-Based High-k Dielectrics: A Platform for Flexible and Biodegradable Transient Electronics.

Transient electronics, designed to degrade after a defined period, are ideal for biomedical implants that eliminate the need for secondary removal surgeries and contribute to sustainable electronics by leaving no electronic waste. While significant progress has been made in developing semiconductors, electrodes, and substrates, dielectric layers for bioapplicable transient electronics that combine flexibility, self-healing capabilities, and high dielectric constants (high-k) remain underexplored. This study introduces urea-linked polycaprolactone (PCL-IU)/ionic liquid (IL) hybrids as dielectric materials.