Adaptive integration of history variables in constrained mixture models for organ-scale growth and remodeling.

In the last decades, many computational models have been developed to predict soft tissue growth and remodeling (G&R). The constrained mixture theory describes fundamental mechanobiological processes in soft tissue G&R and has been widely adopted in cardiovascular models of G&R. However, even after two decades of work, large organ-scale models are rare, mainly due to high computational costs (model evaluation and memory consumption), especially in long-range simulations.

Museomics help resolving the phylogeny of snowfinches (Aves, Passeridae, Montifringilla and allies).

Historical specimens from museum collections provide a valuable source of material also from remote areas or regions of conflict that are not easily accessible to scientists today. With this study, we are providing a taxon-complete phylogeny of snowfinches using historical DNA from whole skins of an endemic species from Afghanistan, the Afghan snowfinch, Pyrgilauda theresae. To resolve the strong conflict between previous phylogenetic hypotheses, we generated novel mitogenome sequences for selected taxa and genome-wide SNP data using ddRAD sequencing for all extant snowfinch species endemic to the Qinghai-Tibet Plateau (QTP) and for an extended intraspecific sampling of the sole Central and Western Palearctic snowfinch species (Montifringilla nivalis).

Adaptive integration of history variables in constrained mixture models for organ-scale growth and remodeling.

In the last decades, many computational models have been developed to predict soft tissue growth and remodeling (G&R). The constrained mixture theory describes fundamental mechanobiological processes in soft tissue G&R and has been widely adopted in cardiovascular models of G&R. However, even after two decades of work, large organ-scale models are rare, mainly due to high computational costs (model evaluation and memory consumption), especially in long-range simulations.

A homogenized constrained mixture model of cardiac growth and remodeling: analyzing mechanobiological stability and reversal.

Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function both globally and locally. Biomechanical, neurohormonal, and genetic stimuli drive these patterns through changes in myocyte dimension and fibrosis. We propose a novel microstructure-motivated model that predicts organ-scale G&R in the heart based on the homogenized constrained mixture theory.

Cognitive deficits in patients with peripheral vestibular dysfunction.

Background And Purpose: Previous studies demonstrated cognitive deficits in patients with peripheral vestibulopathy (PVP) with dysfunction of spatial navigation and orientation, but also documented cognitive decline in nonspatial abilities. This study evaluates cognitive deficits in patients with unilateral vestibulopathy (UVP) as well as bilateral vestibulopathy (BVP) in multiple cognitive domains using common screening tests to reliably detect these deficits in clinical practice.

Methods: This prospective study compared patients with UVP and BVP to age- and sex-matched healthy controls (HC).

The impact of a standardized Enhanced Recovery After Surgery (ERAS) protocol in patients undergoing minimally invasive heart valve surgery.

Background: An enhanced recovery after surgery (ERAS) protocol is a multimodal and multi-professional strategy aiming to accelerate postoperative convalescence. Pre-, intra- and postoperative measures might furthermore reduce postoperative complications and hospital length of stay (LOS) in a cost-effective way. We hypothesized that our unique ERAS protocol leads to shorter stays on the intensive care unit (ICU) and a quicker discharge without compromising patient safety.

The Small Molecule GAL-201 Efficiently Detoxifies Soluble Amyloid β Oligomers: New Approach towards Oral Disease-Modifying Treatment of Alzheimer's Disease.

Soluble amyloid β (Aβ) oligomers have been shown to be highly toxic to neurons and are considered to be a major cause of the neurodegeneration underlying Alzheimer's disease (AD). That makes soluble Aβ oligomers a promising drug target. In addition to eliminating these toxic species from the patients' brain with antibody-based drugs, a new class of drugs is emerging, namely Aβ aggregation inhibitors or modulators, which aim to stop the formation of toxic Aβ oligomers at the source.

Gyroscopic performance and some seismic measurements made with a 10 meter perimeter ring laser gyro housed in the Ernest Rutherford building.

We describe the construction and operation of a large ring laser whose beam paths enclose an area of 6.25. The gyroscopic performance of this large laser interferometer was determined using laser operation at a wavelength of 632.

Reconstruction of the Instantaneous Earth Rotation Vector with Sub-Arcsecond Resolution Using a Large Scale Ring Laser Array.

Absolute rotation rate sensing with extreme sensitivity requires a combination of several large scale gyroscopes in order to obtain the full vector of rotation. We report on the construction and operation of a four-component, tetrahedral laser gyroscope array as large as a five story building and situated in a near surface, underground laboratory. It is demonstrated that reconstruction of the full Earth rotation vector can be achieved with sub-arcsecond resolution over more than six weeks.

Assessment of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids, in patients with persistent atrial fibrillation: Rationale and design of the PROMISE-AF phase II study.

We designed a placebo controlled, double-blind, randomized, dose-finding phase II study on OMT-28 in the maintenance of sinus rhythm after electrical cardioversion (DCC) in patients with persistent atrial fibrillation (PROMISE-AF). OMT-28 is a first-in-class, synthetic analog of 17,18-epoxyeicosatetetraenoic acid, a bioactive lipid mediator generated by cytochrome P450 enzymes from the omega-3 fatty acid eicosapentaenoic acid. OMT-28 improves Ca-handling and mitochondrial function in cardiomyocytes and reduces pro-inflammatory signaling.

[Evaluation of Quality Indicators of Evidence-Based Guidelines Using ADT/GEKID Base Dataset and its Organ-Specific Modules].

Aim: According to the Cancer Screening and Registers Act (KFRG, §65c SGB V), clinical cancer registration in Germany has to be based on the consistent set of variables developed by the "Association of German Tumor Centers" (ADT) and "Association of Population-based Cancer Registries in Germany" (GEKID) to improve oncological care. Quality indicators in evidence-based guidelines are measures to assess the quality of treatment and outcome in clinical care. The aim of this study was to find out the extent to which it is possible to determine these quality indicators using the ADT/GEKID's set of variables and the organ-specific modules.

Draft Genome Sequence of DSM 108379, a Ubiquitous Fungus on Hardwood.

The saprotrophic ascomycete is a widespread wood-decaying fungus on deciduous trees. Here, we report its draft genome sequence. The genome assembly has a size of 42.

Draft Genome Sequence of the Wood-Staining Ascomycete DSM 107184.

DSM 107184 is a wood-decomposing ascomycetous fungus known to produce the bluish-green dimeric naphthoquinone derivate xylindein. Here, we present the first draft genome sequence, which contains 588 contigs with a total length of 33.1 Mb.

Draft Genome Sequence of Xylaria longipes DSM 107183, a Saprotrophic Ascomycete Colonizing Hardwood.

The saprotrophic soft-rot fungus was isolated from deadwood of collected in the Bavarian Forest, Germany. The whole genome of this strain (DSM 107183) was sequenced with a total size of 43.2 Mb and a G+C content of 48.

Draft Genome Sequence of Scytalidium lignicola DSM 105466, a Ubiquitous Saprotrophic Fungus.

Scytalidium lignicola is a ubiquitous anamorphic ascomycete and belongs to a genus that includes several phytopathogenic fungi. The strain sequenced in this study (DSM 105466) was isolated from leaves of Quercus robur. The draft genome has a size of 47.

Draft Genome Sequence of the Sordariomycete () CBS 245.38.

() , a soil- and lignocellulose-inhabiting sordariomycete (Ascomycota) that can also live as a facultative tree pathogen causing soft rot, belongs to the family Coniochaetaceae. The strain CBS 245.38 sequenced here was assembled into 869 contigs, has a size of 30.

Draft Genome Sequence of the Wood-Degrading Ascomycete DSM 104547.

We report here the draft genome of () , an ascomycetous fungus that colonizes and substantially degrades hardwood and can infest living broad-leaved trees. The genome was assembled into 858 contigs, with a total size of 46.5 Mb, and 11,074 protein-coding genes were predicted.

Deep underground rotation measurements: GINGERino ring laser gyroscope in Gran Sasso.

GINGERino is a large frame laser gyroscope investigating the ground motion in the most inner part of the underground international laboratory of the Gran Sasso, in central Italy. It consists of a square ring laser with a 3.6 m side.

High-accuracy absolute rotation rate measurements with a large ring laser gyro: establishing the scale factor.

Large ring lasers have exceeded the performance of navigational gyroscopes by several orders of magnitude and have become useful tools for geodesy. In order to apply them to tests in fundamental physics, remaining systematic errors have to be significantly reduced. We derive a modified expression for the Sagnac frequency of a square ring laser gyro under Earth rotation.

Status and perspective of lab-on-a-chip systems for common diseases: a systematic review from 2003 to 2013.

Background: Lab-on-a-chip systems (LOCs) are a useful aid for the individualization of therapeutic algorithms at the point-of-care.

Materials & Methods: We performed a systematic literature review on LOCs for diseases with a global impact for healthcare.

Results: A total of 1007 articles matched the previously specified search criteria, thereof 65 studies could be included in this review.

Diagnostic lab-on-a-chip systems at the doctor's office: a survey amongst German physicians in routine medical care.

Aim & Method: We conducted a physician's survey to ask the potential 'users' about needs and options for lab-on-a-chip systems (LOCs) in their office to provide information about the feasibility of the implementation of LOCs into the healthcare system.

Results: From a random sample of 300 questionnaires, 61 were returned. The willingness to use LOCs is very high (91.

Standardized medical age assessment of refugees with questionable minority claim-a summary of 591 case studies.

In order to establish identity of asylum seekers, part of which is age clarification, administrative authorities are obliged to investigate the credibility of allegations based on the usual means of evidence to determine the applicable legal background. In case of serious doubts concerning age minority declaration, medical expert opinion builds the key proof bound by a complex framework consisting of EU regulations, domestic legal backgrounds and the scientific 'state of the art,' the latter being largely influenced by the pursuit of the German 'Study Group on Forensic Age Diagnostics.' Our application example demonstrates the exceptional value of its guidelines serving evidence-based understanding of the age issue in borderline adults within the asylum context.

Opportunities and risks of diagnostic lab-on-a-chip systems in healthcare from a health system stakeholder's perspective.

Aim: The aim of personalized medicine is to respond to the needs of individuals with appropriate treatment. Lab-on-a-chip systems (LOCs) can help to individualize therapeutic algorithms at the point of care. Herein, we discuss the perspectives, demands and concerns associated with LOCs.