Publications by authors named "Geanne Matos"
Alzheimer's Disease Immunotherapy and Mimetic Peptide Design for Drug Development: Mutation Screening, Molecular Dynamics, and a Quantum Biochemistry Approach Focusing on Aducanumab::Aβ2-7 Binding Affinity.
Victor L B França Eveline M Bezerra Roner F da Costa Hernandes F Carvalho Valder N Freire Geanne Matos
ACS Chem Neurosci
October 2024
Article Synopsis
- * Researchers used advanced techniques like mutation screening and molecular dynamics to analyze how Aducanumab interacts with amyloid-beta (Aβ), finding that certain regions of the antibody contribute significantly to its binding affinity.
- * A mutation that was thought to increase Aducanumab's binding actually reduced its stability, while new computationally designed peptides show promise as potential inhibitors of Aβ aggregation, suggesting new directions for Alzheimer's treatment.