Publications by authors named "Gean Hu"
Understanding of the mechanisms that initiate clathrin-mediated endocytosis (CME) is incomplete. Recent studies in budding yeast identified the endocytic adaptor protein Yap1801/Yap1802 (budding yeast AP180) as a key CME factor that promotes CME initiation in daughter cells during polarized growth, but how Yap1801/2 is recruited preferentially to the plasma membrane of daughter cells is not clear. The only known cargos for Yap1801/2 in yeast are the synaptobrevins Snc1 and Snc2, which act as v-SNARES for exocytic vesicles arriving at the plasma membrane and are essential for polarized cell growth.
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- - CME is a vital process for moving substances into cells, starting with the formation of a protein network at the cell membrane, but the exact initiation method is unclear.
- - In budding yeast, daughter cells have more anionic phospholipids and cargo, suggesting that this difference plays a role in CME initiation at the plasma membrane.
- - The study reveals that specific yeast proteins work together with these phospholipids and cargo to form complexes that kickstart CME, highlighting a coordinated mechanism for site initiation.