Publications by authors named "Ge Xu"
Background: Extracting psychological counseling help-seeker information from unstructured text is crucial for providing effective mental health support. This task involves identifying personal emotions, psychological states, and underlying psychological issues but faces significant challenges. These challenges include the sensitivity of mental health data, the lack of Chinese instruction datasets, and the difficulties large language models (LLMs) encounter with complex natural language understanding tasks.
View Article and Find Full Text PDFFXYD5 regulates gastric cancer cell metastasis and drug resistance by EMT modulation.
Cancer Gene Ther
February 2025
Gastric cancer (GC) is the third leading cause of cancer-related mortality and the fourth most prevalent malignancy globally. The high prevalence and mortality rates of GC are attributed to various factors, including drug resistance, local recurrence, and distant metastases. There is an urgent need to identify novel therapeutic targets for GC.
View Article and Find Full Text PDFThe Tibetan Plateau plays a vital role in regional ecological stability and exerts significant influence on the global climate system. Intrusion of radioactive pollutant from potential sources would pose radiation threat to its ecological environment. Preliminary findings suggest that iodine-129 (I) from Indian nuclear activities may have reached southern Tibet, providing a good tracer for studying the pathway of possible gaseous radioactive pollutants to the plateau, which is essential for assessing the radiation risk and hazard in the future.
View Article and Find Full Text PDFPorcine circovirus type 2 (PCV2) is a significant pathogen responsible for porcine circovirus-associated diseases (PCVAD), and it is widely prevalent in pig farms, leading to huge economic losses for the pig industry. Currently, the ability of PCV2 to enhance its own replication by using the antiviral inflammatory factors IFNα, IFNβ, and IL-2 and its complex immune escape mechanism remain unclear, which has attracted wide attention. Research has indicated that GTPase-activating protein (SH3 domain)-binding protein 1 (G3BP1) is involved in the innate immune response to a variety of viruses, primarily by regulating and composing stress granules (SGs) to inhibit viral replication.
View Article and Find Full Text PDFInjectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment.
Int J Nanomedicine
February 2025
Background: Osteoarthritis (OA), a prevalent joint disease, causes immense suffering to thousands of patients, impairing their mobility and diminishing their quality of life. Current treatment methods primarily rely on analgesics or anti-inflammatory drugs to alleviate symptoms but fail to achieve the desired therapeutic outcome.
Methods: To better realize therapeutic effects of OA, procyanidins (PAs), as a type of plant flavonoids with strong antioxidant and anti-inflammatory activities, were designed to self-assembly with well-dispersible Pluronic F127 (PF127) through the hydrogen-bond interaction to present an injectable, biocompatibility PA nanospheres.
Objective: To systematically evaluate the effectiveness of non-pharmacological interventions (NPIs), including electroacupuncture, exercise, diet, and lifestyle changes, in reducing androgen levels in women with polycystic ovary syndrome (PCOS) through a systematic review and network meta-analysis.
Methods: Comprehensive searches were conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang up to June 2024. Randomized controlled trials (RCTs) comparing NPIs with other NPIs or placebo treatments in adult women with PCOS were included.
Background: The emergence of drug-resistant Tuberculosis (TB) has made treatment challenging. Although fluoroquinolones (FQs) are used as key drugs in the treatment of multidrug-resistant tuberculosis (MDR-TB), the problem of FQs resistance is becoming increasingly serious. Rifampicin (RIF) resistance is considered a risk factor for FQs resistance.
View Article and Find Full Text PDFEpimedium applied in the clinical treatment of osteoporosis patients with periodontitis.
Medicine (Baltimore)
December 2024
Article Synopsis
- Osteoporosis and periodontitis are linked by common issues of bone loss and inflammation, prompting a study on the benefits of Epimedium for patients with both conditions.
- The study involved 120 patients divided into two groups, with one receiving standard treatment (calcium, vitamin D, and zoledronic acid) and the other receiving this treatment plus Epimedium.
- Results showed that the Epimedium group experienced greater improvements in bone mineral density, better periodontal health, and lower inflammation markers, indicating it may effectively enhance existing osteoporosis treatments in patients with periodontitis.
Article Synopsis
- The study aimed to assess the impact of zoledronic acid on periodontal health, inflammation, and bone metabolism in postmenopausal osteoporosis patients suffering from periodontitis.
- Out of 113 participants, those treated with zoledronic acid showed significantly better improvements in periodontal indices, decreased inflammatory markers, and enhanced bone mineral density compared to those receiving standard therapy.
- Results indicate that zoledronic acid is effective in improving periodontal health and bone metabolism in this patient group, without a notable increase in adverse effects.
Article Synopsis
- Pea protein is gaining popularity for its nutritional benefits and texture, meeting consumer demands for plant-based protein.
- Ultrasonic treatment (varying power and duration) significantly improves the solubility, adhesiveness, and gel strength of commercial pea protein isolates.
- The study shows that adjusting ultrasonic parameters can effectively customize the texture of pea protein products, making them comparable to those made in lab settings.
Article Synopsis
- The study focuses on how isochlorogenic acid A (IAA) and Lycium barbarum glycopeptide (LbGp) interact to enhance immune system regulation.
- Their interaction results in the formation of a complex that enhances the ability of immune cells to proliferate and respond to inflammatory signals.
- This research highlights the potential of combining glycopeptides and polyphenols to improve immunomodulatory effects without triggering inflammation.
Article Synopsis
- The objective of the study was to find out what factors can increase the risk of children developing epilepsy after having febrile seizures.
- Researchers looked at many studies and analyzed data from 23 different research articles involving over 5,000 children.
- The results showed that several factors like having multiple seizures, a family history of epilepsy, and other medical issues can increase the risk, while being female didn’t really matter.
Article Synopsis
- * Three electron transport channels were identified: a solid-state Z-scheme involving titanium dioxide and silver bromide, a plasmon resonance effect from silver nanoparticles, and a redox coupling medium with oxygen vacancies.
- * The effectiveness of the heterojunction was tested through the photocatalytic degradation of tetracycline, aiming to provide insights for developing advanced titanium dioxide heterojunctions with improved electron transport pathways.
Article Synopsis
- The proposed memory-enhanced multi-stage goal-driven network (ME-MGNet) aims to improve egocentric trajectory prediction by using a scene layout memory that mimics human perception.
- The approach involves first matching the current scene with past visually similar ones to retrieve useful trajectories, followed by generating goal features through trajectory-level matching.
- The method incorporates these features into a conditional autoencoder and forward decoder framework, producing trajectory predictions that were validated against multiple datasets, showcasing its effectiveness.
Article Synopsis
- RNA N-methyladenosine (mA) methylation is a key modification in eukaryotic RNA that regulates RNA metabolism and is involved in various diseases.
- Non-coding RNAs (ncRNAs) can be influenced by mA methylation, which is important for understanding their biological roles and potential clinical applications.
- The review highlights recent research on the interaction between mA modifications and different types of ncRNAs, as well as the challenges and future prospects of utilizing mA in therapeutic strategies for human diseases.
Article Synopsis
- The optoacoustic transducer is gaining recognition in medical ultrasound applications, specifically for its potential in diagnostics and treatments, despite concerns over laser-induced damage.
- A theoretical model was developed to understand the nature of laser-induced damage in a carbon nanotubes-polydimethylsiloxane (CNT-PDMS) composite transducer, revealing that the damage is primarily due to thermal ablation.
- Experimental results support the theoretical findings, indicating that the transducer operates stably for extended periods when laser energy density is kept below a specific threshold.
Article Synopsis
- GNS (Graphene nanoscroll) is a significant tubular form of graphene materials, but traditional manufacturing methods are often complicated and slow.
- A new air-plasma synthesis method has been developed to create 3D graphene nanoscroll-nanosheet aerogels (GSSA) using graphene oxide, achieving high efficiency without chemicals and in just 1 second at room temperature.
- GSSA not only enhances electron transport in electrodes for capacitive deionization (CDI) but also prevents the restacking of graphene sheets, indicating potential for large-scale production and effective applications in salt removal and other areas.
Article Synopsis
- The steroid hormone 17β-estradiol (E2) promotes tumor growth and metabolism by increasing reactive oxygen species (ROS) levels, but this increase is not harmful enough to destroy cancer cells.
- Research focused on the Ishikawa endometrial cancer cell line showed that E2 regulates ROS levels and protects cells from apoptosis by enhancing the expression of FOXM1.
- Findings indicated that lower FOXM1 levels lead to more oxidative damage, while E2 treatment raised both FOXM1 and ERα levels, suggesting E2’s role in preventing oxidative stress-induced cell death in endometrial cancer.
Article Synopsis
- Pseudoaneurysm can be a serious complication that arises after a heart attack.
- This study discusses a rare case where a patient suffered from a rupture in the left ventricular wall, identified more than a year after a heart procedure.
- The detection was achieved using cardiac magnetic resonance imaging, highlighting the importance of ongoing monitoring post-intervention.
Article Synopsis
- - Exercise enhances heart function and metabolism, but its impact on protein modifications like lactylation is not fully understood.
- - The study finds that lactate regulates changes in heart muscle cells (cardiomyocytes) by increasing protein lactylation and levels of the RNA-binding protein YTHDF2, which affects cell size and apoptosis during stress conditions.
- - Targeting lactylation or inhibiting YTHDF2 could provide new treatment strategies for heart diseases by promoting healthy cardiac adaptations to exercise.
Article Synopsis
- ACL tears are common injuries in sports, often leading to cartilage damage which affects both physical health and mental well-being.
- Recent research suggests that procyanidins may be effective in repairing cartilage injuries due to their anti-inflammatory and antioxidant properties.
- The article summarizes the mechanisms and clinical significance of procyanidins in cartilage repair, offering new insights and potential future applications in treating ACL-related cartilage damage.
Article Synopsis
- PMI is an active alkaloid from Fritillaria thunbergii that shows potential in suppressing tumor growth, particularly in breast cancer, although its specific mechanisms are not fully understood.
- Researchers assessed the cytotoxic effects of PMI on breast cancer cell lines using various assays, revealing that PMI decreases cell viability, increases damage indicators, and suppresses both in vitro proliferation and in vivo tumor growth by inducing ferroptosis.
- The study suggests that PMI triggers ferroptosis in breast cancer cells through the activation of the Nrf2-HO-1 signaling pathway, with evidence showing that inhibiting Nrf2 significantly counters PMI's anti-tumor effects.