The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond.

Cancer, a complicated disease characterized by aberrant cellular metabolism, has emerged as a formidable global health challenge. Since the discovery of abnormal aldolase A (ALDOA) expression in liver cancer for the first time, its overexpression has been identified in numerous cancers, including colorectal cancer (CRC), breast cancer (BC), cervical adenocarcinoma (CAC), non-small cell lung cancer (NSCLC), gastric cancer (GC), hepatocellular carcinoma (HCC), pancreatic cancer adenocarcinoma (PDAC), and clear cell renal cell carcinoma (ccRCC). Moreover, ALDOA overexpression promotes cancer cell proliferation, invasion, migration, and drug resistance, and is closely related to poor prognosis of patients with cancer.

The effects of mobile phone addiction on learning engagement of Chinese college students - the mediating role of physical activity and academic self-efficacy.

Background: With the widespread adoption of smartphones, mobile phone addiction has increasingly gained prominence among Chinese college students, exerting a profound and detrimental impact on their learning engagement. This study employs self-determination theory as a framework to examine the mechanisms through which mobile phone addiction affects students' learning engagement. Specifically, it examines the mediating effects of physical activity and academic self-efficacy in this relationship.

The effects of mobile phone addiction on bedtime procrastination in university students: the masking effect of physical activity and anxiety.

Purpose: Good sleep is one of the necessary conditions to ensure the normal performance of the physiological and psychological functions of college students. This study aimed to explore the relationship between mobile phone addiction and bedtime procrastination among Chinese college students and the mediating mechanisms of physical exercise and anxiety between the two, with a view to seek ways to prevent and intervene in college students' sleep procrastination and improve their sleep quality.

Methods: Using SPSS 29.

Complex interplay of heavy metals and renal injury: New perspectives from longitudinal epidemiological evidence.

Background: Epidemiological studies have reported associations between heavy metals and renal function. However, longitudinal studies are required to further validate these associations and explore the interactive effects of heavy metals on renal function and their directional influence.

Method: This study, conducted in Northeast China from 2016 to 2021, included a four-time repeated measures design involving 384 participants (1536 observations).

Developmental pleiotropy of SDP1 from seedling to mature stages in B. napus.

Rapeseed, an important oil crop, relies on robust seedling emergence for optimal yields. Seedling emergence in the field is vulnerable to various factors, among which inadequate self-supply of energy is crucial to limiting seedling growth in early stage. SUGAR-DEPENDENT1 (SDP1) initiates triacylglycerol (TAG) degradation, yet its detailed function has not been determined in B.

Joint and interactive effects of metal mixtures on liver damage: Epidemiological evidence from repeated-measures study.

Background: The impact of heavy metals on liver function has been examined in numerous epidemiological studies. However, these findings lack consistency and longitudinal validation.

Methods: In this study, we conducted three follow-up surveys with 426 participants from Northeast China.

In Operando Monitoring the Stress Evolution of Silicon Anode Electrodes during Battery Operation via Optical Fiber Sensors.

Silicon (Si) anode has attracted broad attention because of its high theoretical specific capacity and low working potential. However, the severe volumetric changes of Si particles during the lithiation process cause expansion and contraction of the electrodes, which induces a repeatedly repair of solid electrolyte interphase, resulting in an excessive consuming of electrolyte and rapid capacity decay. Clearly known the deformation and stress changing at µε resolution in the Si-based electrode during battery operation provides invaluable information for the battery research and development.

Nonvisual system-mediated body color change in fish reveals nonvisual function of Opsin 3 in skin.

Body-color changes in many poikilothermic animals can occur quickly. This color change is generally initiated by visual system, followed by neuromuscular or neuroendocrine control. We have previously showed that the ventral skin color of the large yellow croaker (Larimichthys crocea) presents golden yellow in dark environment and quickly changes to silvery white in light environment.

Neurotransmitter norepinephrine regulates chromatosomes aggregation and the formation of blotches in coral trout Plectropomus leopardus.

Color changes and pattern formations can represent strategies of the utmost importance for the survival of individuals or of species. Previous studies have associated capture with the formation of blotches (areas with light color) of coral trout, but the regulatory mechanisms link the two are lacking. Here, we report that capture induced blotches formation within 4-5 seconds.

Thyroid disrupting effects of multiple metals exposure: Comprehensive investigation from the thyroid parenchyma to hormonal function in a prospective cohort study.

This study aimed to investigate the thyroid disrupting effects of multiple metals exposure with comprehensive investigation from the thyroid parenchyma to hormonal function. In this prospective cohort study of in-service staff of the Baoding Power Supply, we found that arsenic was negatively associated with total thyroxine (TT4) [β = -0.075, 95% confidence interval (CI): -0.

The Effects of Short-Term Exposure to pH Reduction on the Behavioral and Physiological Parameters of Juvenile Black Rockfish ().

Coastal areas are subject to greater pH fluctuation and more rapid pH decline as a result of both natural and anthropogenic influences in contrast to open ocean environments. Such variations in pH have the potential to pose a threat to the survival and physiological function of offshore fishes. With the aim of evaluating the impact of short-term pH reduction on the behavioral performance and physiological response of costal fish, the black rockfish (), one of the principal stock-enhanced species, was examined.

Threshold effect of urinary chromium on kidney function biomarkers: Evidence from a repeated-measures study.

Chronic kidney disease (CKD) is a public health concern worldwide, and chromium exposure may be a risk factor due to its potential nephrotoxicity. However, research on the association between chromium exposure and kidney function especially the potential threshold effect of chromium exposure is limited. A repeated-measures study involving 183 adults (641 observations) was conducted from 2017 to 2021 in Jinzhou, China.

Transport model simulation prediction and environmental risk assessment of pyrethroid insecticides in urban artificial lakes caused by rainfall: A case study of Cloud Mountain Park in subhumid climate zone.

Pyrethroid insecticides are among urban parks' most widely used and harmful insecticides. The advanced prediction method is the key to studying the pollution and diffusion risk of plant conservation insecticides in parks. A two-dimensional advection-dispersion model was established for the North Lake of Cloud Mountain Park in the subhumid area of Hebei Province.

Xanthophyll esterases in association with fibrillins control the stable storage of carotenoids in yellow flowers of rapeseed (Brassica juncea).

Biosynthesis, stabilization, and storage of carotenoids are vital processes in plants that collectively contribute to the vibrant colors observed in flowers and fruits. Despite its importance, the carotenoid storage pathway remains poorly understood and lacks thorough characterization. We identified two homologous genes, BjA02.

Associations of metals and metals mixture with lipid profiles: A repeated-measures study of older adults in Beijing.

Metals inevitably and easily enter into human bodies and can induce a series of pathophysiological changes, such as oxidative stress damage and lipid peroxidation, which then may further induce dyslipidemia. However, the effects of metals and metals mixture on the lipid profiles are still unclear, especially in older adults. A three-visits repeated measurement of 201 older adults in Beijing was conducted from November 2016 to January 2018.

Association of environmental exposure to chromium with differential DNA methylation: An epigenome-wide study.

Previous studies have reported that chromium (Cr)-induced epigenetic alterations and DNA methylation play a vital role in the pathogenesis of diseases induced by chromium exposure. Epigenomic analyses have been limited and mainly focused on occupational chromium exposure; their findings are not generalizable to populations with environmental Cr exposure. We identified the differential methylation of genes and regions to elucidate the mechanisms of toxicity related to environmental chromium exposure.

Independent, combine and interactive effects of heavy metal exposure on dyslipidemia biomarkers: A cross-sectional study in northeastern China.

Dyslipidemia is a common disease in the older population and represents a considerable disease burden worldwide. Epidemiological and experimental studies have indicated associations between heavy metal exposure and dyslipidemia; few studies have investigated the effects of heavy metal mixture and interactions between metals on dyslipidemia. We recruited 1121 participants living in heavy metal-contaminated and control areas in northeast China from a cross-sectional survey (2017-2019).

Effects of Low-Impact Development Facilities (Water Systems of the Park) on Stormwater Runoff in Shallow Mountainous Areas Based on Dual-Model (SWMM and MIKE21) Simulations.

Rapid urbanization has triggered more serious urban flood risks. Many studies have focused on intra-urban flooding, but less attention has been paid to rainfall and flood risks at the urban fringe. Nowadays, China is vigorously promoting the construction of sponge cities in the whole area.

Ultrastructure and regulation of color change in blue spots of leopard coral trout .

The leopard coral trout generally exhibited numerous round, minute blue spots covering its head (about the size of nostril) and body (except ventral side). This is a characteristic that distinguishes them from similar species. Recently, however, we found the leopard coral trout with black spots.

Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies.

Background: Limited evidence suggests the association of air pollutants with a series of diabetic cascades including inflammatory pathways, glucose homeostasis disorder, and prediabetes and diabetes. Subclinical strategies for preventing such pollutants-induced effects remain unknown.

Methods: We conducted a cross-sectional study in two typically air-polluted Chinese cities in 2018-2020.

Prediction of the impact of benzo[a]pyrene on shallow groundwater during natural infiltration of reclaimed water-receiving rivers: A case study of Liangshui, China.

The quality of groundwater along rivers is greatly affected by long-term infiltration from surface water, especially reclaimed water-receiving rivers. To predict the degree of influence of contaminated river water on groundwater quality, the spatiotemporal distribution and migration evolution prediction of benzo[a]pyrene (B(a)P) was monitored and simulated by Hydrus-coupled Groundwater Modeling Systems (GMS) model in terms of reclaimed water-receiving Liangshui River. The prediction results indicated the goodness-of-fit of this coupled model, according to the model efficiency (E: 0.

Associations and burdens of relative humidity with cause-specific mortality in three Chinese cities.

This study aimed to investigate the association between relative humidity (RH) and various cause of mortality, and then quantify the RH-related mortality fraction of low and high RH under the assumption that causal effects exist. Daily cause-specific mortality counts from 2008 to 2011, and contemporaneous meteorological data in three Chinese cities were collected. Distributed lag nonlinear models were adopted to quantify the nonlinear and delayed effects of RH on mortality risk.

The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing.

Background & Aims: Few epidemiological studies have investigated the relationships of urinary essential and non-essential elements with serum albumin, an indicator of nutritional status, especially for the elderly in China.

Methods: A community-based study among elderly participants ( = 275) was conducted in Beijing from November to December 2016. We measured 15 urinary elements concentrations and serum albumin levels.

Novel Strategies for Assessing Associations Between Selenium Biomarkers and Cardiometabolic Risk Factors: Concentration, Visit-to-Visit Variability, or Individual Mean? Evidence From a Repeated-Measures Study of Older Adults With High Selenium.

Background And Aims: Previous studies have focused only on the cardiometabolic effects of selenium concentrations. We explored whether selenium levels and their visit-to-visit variability (VVV) and individual mean (IM) are independently associated with cardiometabolic risk factors.

Methods: A three-wave repeated-measures study of older adults with high selenium ( = 201) was conducted in Beijing from 2016 to 2018.

Association of Metals and Metalloids With Urinary Albumin/Creatinine Ratio: Evidence From a Cross-Sectional Study Among Elderly in Beijing.

Background: Environmental exposure to toxic elements contributes to the pathogenesis of chronic kidney disease (CKD). Few studies focus on the association of urinary metals and metalloids concentrations with the urinary albumin/creatinine ratio (UACR) among elderly, especially in areas and seasons with severe air pollution.

Objective: We aimed to evaluate the associations of urinary metals and metalloids concentration with UACR, which is an early and sensitive indicator of CKD.