2-Ethylhexyl diphenyl phosphate induces lung oxidative stress and pyroptosis in chicks.

2-Ethylhexyl diphenyl phosphate (EHDPHP) is a widely used organophosphorus flame retardant and plasticizer easily released into the environment. Its biological toxicity is of great concern. The lung is considered a possible target organ for EHDPHP, but currently, there are limited studies on the biotoxicity of EHDPHP in poultry lungs.

Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption.

Poultry molting is a natural phenomenon, and process that improves the physiological function of laying hens. In this study, artificial intervention was used to induced molting (IM) in aged hens and improve their egg- laying performance. Jejunal lipophagy and lipid metabolism data were analyzed to elucidate the regulatory mechanisms by which the intestine affects egg production performance, particularly through the lens of digestion and absorption processes.

A predictive model for cerebellar mutism syndrome based on lesion map in children with medulloblastoma.

Background: This study aimed to establish a voxel-based map to predict the occurrence of cerebellar mutism syndrome (CMS) and investigate the relationship between CMS and motor dysfunction.

Method: This multicenter study cohort included 224 patients diagnosed with medulloblastoma at Beijing Children's Hospital (n = 88) and Beijing Tiantan Hospital (n = 136). The dataset was randomly divided into training (n = 95), test (n = 41), and validation (n = 88) datasets.

Multi-Scale Temporal-Spatial Feature-Based Hybrid Deep Neural Network for Remaining Useful Life Prediction of Aero-Engine.

Remaining useful life (RUL) prediction is crucial for simplifying maintenance procedures and extending the lifespan of aero-engines. Therefore, research on RUL prediction methods for aero-engines is increasingly gaining attention. In particular, some existing deep neural networks based on multiscale features extraction have achieved certain results in RUL predictions for aero-engines.

Evaluation model design of project construction safety level based on bidirectional recurrent neural network (BiRNN) and bidirectional long short-term memory (BiLSTM).

Integrating deep learning methods for multi-element regression analysis poses a challenge in constructing safety evaluations for building construction. To address this challenge, this paper evaluates the integration of construction safety by quantitatively analyzing practitioners' information and on-site construction conditions. The analytic hierarchy process (AHP) method quantifies construction safety capabilities, considering four key aspects: operators' primary conditions, organizational personnel's working conditions, on-site management conditions, and analysis of unsafe behaviors.

Multiple Strategies to Build High-Performance Spherical Na-Ion Layered Oxide Cathodes.

The development prospect of layered transition metal oxides in sodium-ion batteries is excellent, but there are some problems, such as poor cycle stability and a complex phase transition. The spherical NaNiFeMnTiSnCoLiO (SP-HEO) has been developed to address the challenges faced by O3-type layered oxide in sodium-ion batteries. The SP-HEO material is synthesized by piling and high entropy.

Association of Ozone and Temperature with Ischemic Heart Disease Mortality Risk: Mediation and Interaction Analyses.

Global warming and elevated ozone (O) levels are gradually gaining widespread attention, and exposure to which may cause many physiological changes associated with cardiovascular events such as hypertension, cardiomyocyte apoptosis, etc. In addition, ischemic heart disease (IHD) is the leading cause of death worldwide. However, the contributions of temperature and O, independently or in combination, to IHD mortality are not well understood.

Growth Modulation of High-Entropy Alloys for Electrocatalytic Methanol Oxidation Reaction.

High-entropy alloy (HEA) electrocatalysts have exhibited remarkable catalytic performance because of their synergistic interactions among multiple metals. However, the growth mechanism of HEAs remains elusive, primarily due to the constraints imposed by the current synthesis methodologies for HEAs. In this work, an innovative electrodeposition method was developed to fabricate Pt-based nanocomposites (PtBiCoCuNi/CC), comprising HEA nanosheets and carbon cloths (CCs).

Precise Construction of the Triple-Phase Boundary and Its Antiphosphate Poisoning Effect in the Confined Region.

As a critical component for the oxygen reduction reaction (ORR), platinum (Pt) catalysts exhibit promising catalytic performance in High-temperature-proton exchange membrane fuel cells (HT-PEMFCs). Despite their success, HT-PEMFCs primarily utilize phosphoric acid-doped polybenzimidazole (PA-PBI) as the proton exchange membrane, and the phosphoric acid within the PBI matrix tends to leach onto the Pt-based layers, easily causing toxicity. Herein, we first propose UiO-66@PtCo-T composites with precisely engineered interfacial structures.

Electronegativity- induced cobalt-doped platinum hollow nanospheres with high CO tolerance for efficient methanol oxidation reaction.

Although Platinum (Pt)-based alloys have garnered significant interest within the realm of direct methanol fuel cells (DMFCs), there still exists a notable dearth in the exploration of the catalytic behavior of the liquid fuels on well-defined active sites and unavoidable Pt poisoning because of the adsorbed CO species (CO). Here, we propose an electronegativity-induced electronic redistribution strategy to optimize the adsorption of crucial intermediates for the methanol oxidation reaction (MOR) by introducing the Co element to form the PtCo alloys. The optimal PtCo hollow nanospheres (HNSs) exhibit excellent high-quality activity of 3.

Rational Linker Design for Enhanced Performance of MOF-Derived Catalysts in Electrochemical Urea Synthesis.

2D metal-organic frameworks (2D MOFs) offer promising electrocatalytic potential for urea synthesis, yet the underlying reaction mechanisms and structure-activity relationships remain unclear. Using Cu-BDC as a model, density functional theory (DFT) calculations to elucidate these aspects are conducted. The results reveal a novel coupling mechanism involving *NO─CO and *NO─*ONCO, emphasizing the impact of linker modifications on Cu spin states and charge distribution.

Predicting cerebellar mutism syndrome in children using lesion map combined with clinical features.

Objective: This study aimed to develop a predictive model for cerebellar mutism syndrome (CMS) in pediatric patients with posterior fossa tumors, integrating lesion-symptom mapping (LSM) data with clinical factors, and to assess the model's performance.

Methods: A cohort of pediatric patients diagnosed with posterior fossa tumors and undergoing surgery at Beijing Children's Hospital from July 2013 to December 2023 was analyzed. Clinical variables gender, age at surgery, tumor characteristics, hydrocephalus, surgical route and pathology were collected.

Atomic-Dispersed Cu Catalysts for Electrochemical Nitrate Reduction: Coordination Engineering and Fundamental Insights.

The development of Cu-based atomic dispersed catalysts with tailored coordination environments represents a significant step forward in enhancing the electrocatalytic reduction of nitrate to ammonia. By precisely modulating the electronic structures of Cu active centers, the binding strength of the NO intermediates is successfully tuned, thereby substantially improving the catalytic activity toward electrochemical nitrate reduction reaction (eNORR). This study reveals that the N-coordinated Cu single-atom catalyst (Cu-SAC) exhibits superior performance due to its robust interaction with coordinating atoms.

Prilling and Coating Strategy to Synthesize High-Performance Spherical NaNiFeMnO Cathode Materials for Sodium Ion Batteries.

Low-cost sodium ion batteries are of great significance in large-scale energy storage applications. With its high energy density and simple synthesis process, layered transition-metal oxides have become one of the most likely sodium ion battery cathode materials to replace lithium ion batteries in the energy storage market. Here, we report a prilling and MoS coating strategy to prepare the spherical cathode material.

Multi-omics and pharmacological characterization of patient-derived glioma cell lines.

Glioblastoma (GBM) is the most common brain tumor and remains incurable. Primary GBM cultures are widely used tools for drug screening, but there is a lack of genomic and pharmacological characterization for these primary GBM cultures. Here, we collect 50 patient-derived glioma cell (PDGC) lines and characterize them by whole genome sequencing, RNA sequencing, and drug response screening.

2-ethylhexyl diphenyl phosphate exposure induces duodenal inflammatory injury through oxidative stress in chickens.

2-ethylhexyl diphenyl phosphate (EHDPHP) is a widely used organophosphorus flame retardant and plasticizer, which is commonly found in the environment. EHDPHP not only potentially harms the environment but also causes different degrees of damage to the organism. In this study, the duodenum of chicks was selected as the potential toxic target organ to explore the mechanism of duodenal injury induced by EHDPHP exposure.

TGF-β/SMAD Pathway Mediates Cadmium Poisoning-Induced Chicken Liver Fibrosis and Epithelial-Mesenchymal Transition.

Cadmium(Cd) is a toxic heavy metal widely present in the environment, capable of accumulating in the liver and causing liver damage. In this study, the mechanism of cadmium-induced liver fibrosis in chickens was investigated from the perspective of hepatocyte epithelial-mesenchymal transition (EMT) based on the establishment of a model of chicken cadmium toxicity and a model of cadmium-stained cells in a chicken hepatocellular carcinoma cell line (LMH). The 7-day-old chickens were randomly divided into the regular group (C group) and cadmium poisoning group (Cd group), and the entire test cycle was 60 days.

Synthesis of copper/carbon nanofibers by electrostatic spinning toward persulfate activation for treatment of antibiotic wastewater.

Antibiotics in water will cause serious harm to human health and ecosystem. Carbon-based materials and transition metals activated peroxodisulfate (PDS) to produce active species, which can degrade residual antibiotics in water. In this paper, Cu/CNF (carbon nanofibers) composites were first prepared by introducing Cu into CNF using electrostatic spinning technology, which was used to activate PDS to degrade tetracycline (TC).

Assessing the impact of short-term ozone exposure on excess deaths from cardiovascular disease: a multi-pollutant model in Nanjing, China's Yangtze River Delta.

Background: Ozone pollution is associated with cardiovascular disease mortality, and there is a high correlation between different pollutants. This study aimed to assess the association between ozone and cardiovascular disease deaths and the resulting disease burden in Nanjing, China.

Methods: A total of 151,609 deaths from cardiovascular disease were included in Nanjing, China from 2013 to 2021.

Fast-charging aqueous batteries enabled by a three-dimensional ordered Zn anode at deliberate concentration polarization.

A finely controlled concentration polarization environment was deliberately created to fabricate a three-dimensional ordered Zn metal anode with (002)-dominated planes, which enabled a high-rate aqueous Ni-Zn pouch cell with a high discharge capacity of 187.3 mA h g at 50 C, and a capacity retention of 94.7% and an average Coulombic efficiency of 99.

Improving the classification of multiple sclerosis and cerebral small vessel disease with interpretable transfer attention neural network.

As an autoimmune-mediated inflammatory demyelinating disease of the central nervous system, multiple sclerosis (MS) is often confused with cerebral small vessel disease (cSVD), which is a regional pathological change in brain tissue with unknown pathogenesis. This is due to their similar clinical presentations and imaging manifestations. That misdiagnosis can significantly increase the occurrence of adverse events.

Preoxidation and Prilling Combined with Doping Strategy to Build High-Performance Recycling Spent LiFePO Materials.

Direct regeneration has gained much attention in LiFePO battery recycling due to its simplicity, ecofriendliness, and cost savings. However, the excess carbon residues from binder decomposition, conductive carbon, and coated carbon in spent LiFePO impair electrochemical performance of direct regenerated LiFePO. Herein, we report a preoxidation and prilling collaborative doping strategy to restore spent LiFePO by direct regeneration.

PUMC-MB1 is a novel group 3 medulloblastoma preclinical model, sensitive to PI3K/mTOR dual inhibitor.

Purpose: Medulloblastoma (MB), a common and heterogeneous posterior fossa tumor in pediatric patients, presents diverse prognostic outcomes. To advance our understanding of MB's intricate biology, the development of novel patient tumor-derived culture MB models with necessary data is still an essential requirement.

Methods: We continuously passaged PUMC-MB1 in vitro in order to establish a continuous cell line.