Population Genetics of in China Inferred Through EST-SSR Markers.

Background/objectives: The Pacific abalone originated in cold waters and is an economically important aquaculture shellfish in China. Our goal was to clarify the current status of the genetic structure of Pacific abalone in China.

Methods: In this study, eighteen polymorphic EST-SSR loci were successfully developed based on the hemolymph transcriptome data of Pacific abalone, and thirteen highly polymorphic EST-SSR loci were selected for the genetic variation analysis of the six populations collected.

Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression.

Intrahepatic cholangiocarcinoma (iCCA) is a lethal malignancy affecting the liver and biliary system. Enhanced understanding of the pathogenic mechanisms underlying iCCA tumorigenesis and the discovery of appropriate therapeutic targets are imperative to improve patient outcomes. Here, we investigated the functions and regulations of solute carrier family 16 member 3 (SLC16A3), which has been reported to be a biomarker of poor prognosis in iCCA.

Parallel Chart Writing and Resilience Impact the Narrative Competence of Medical Staff in China: A Cross-Sectional Study.

Background And Aims: Narrative competence is essential for good communication between medical staff and patients. It is a powerful instrument for the delivery of holistic healthcare. However, little research focuses on the influencing factors of narrative competence and the relationships among resilience, self-efficacy, and narrative competence.

Mesua ferrea L. extract inhibits cell invasion and tumor growth in breast cancer in vitro and in vivo.

Mesua ferrea L. was commonly used in Uyghur medicine, and the flowering buds of M. ferrea extract exhibited significant inhibitory effects on the proliferation of breast cancer cells in our preliminary research; however, the underlying active components remain to be elucidated.

Case Report: Robot-assisted laparoscopic bladder diverticulectomy: a case series and initial experience.

Objectives: To explore the experience of tumor control technique in robot-assisted laparoscopic bladder diverticulectomy (RALBD) in the treatment of bladder diverticulum tumor, intraoperative tumor control and postoperative comprehensive treatment.

Patients And Methods: We treated three male patients with bladder diverticulum tumors. Case 1 involved a 63-year-old with a 3.

Causal Relationship Between Circulating Metabolites and Sarcopenia-Related Traits: A Mendelian Randomization and Experimental Study.

Sarcopenia (SP), an age-associated condition marked by muscle weakness and loss has been strongly connected with metabolic factors according to substantial evidence. Nevertheless, the causal correlation between SP and serum metabolites, and the biological signaling pathways involved, is still not well understood. We performed a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal relationships between 1091 levels and 309 ratios of metabolites with SP traits, alongside investigating the relevant biological signaling pathways.

Foliar Spraying of Nanoselenium Improves the Nutritional Quality of Alfalfa by Recruiting Beneficial Phyllosphere Bacteria and Regulating the Distribution and Translocation of Selenium.

Nanoselenium shows potential trends in improving plant health and food quality. In this study, different concentrations of nanoselenium were sprayed on the leaves of alfalfa. Compared to the control, nanoselenium (100 mg·L) significantly increased SeMet and SeMeCys contents in the roots, stems, and leaves of alfalfa.

Phycocyanin Additives Regulate Bacterial Community Structure and Antioxidant Activity of Alfalfa Silage.

Phycocyanin is a water-soluble pigment protein extracted from prokaryotes such as cyanobacteria and has strong antioxidant activity. As a silage additive, it is expected to enhance the antioxidant activity and fermentation quality of alfalfa silage. This study revealed the effects of different proportions of phycocyanin (1%, 3%, 5%) on the quality, bacterial community and antioxidant capacity of alfalfa silage.

Effect of Spirulina on the Rumen Microbiota and Serum Biochemical Parameters of Lambs.

Spirulina () is rich in a variety of fermentable fibers and prebiotics, which can promote the proliferation of beneficial flora in the intestinal tract of ruminants and optimize the balance of microorganisms in the rumen. The aim of this study was to evaluate whether dietary supplementation with Spirulina has a beneficial effect on the rumen microbial community and serum indices in lambs. For this purpose, 36 lambs with a mean weight of 21.

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.

While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal, fetal, and child outcomes. Herein we performed a multi-ancestry genome-wide association study (GWAS) of severe nausea and vomiting of pregnancy of 10,974 cases and 461,461 controls across European, Asian, African, and Latino ancestries. We identified ten significantly associated loci, of which six were novel (, , , , , and , and confirmed previous genome-wide significant associations with risk genes , , , and .

On-site biosignal amplification using a single high-spin conjugated polymer.

On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration. Ambipolar organic electrochemical transistors (OECTs) are promising for this purpose due to their high transconductance, low operating voltage, biocompatibility, and suitability for miniaturized amplifier design. However, limitations in material performance and stability have hindered their application in biosignal amplification.

Metabolomics combined with physiology and transcriptomics reveal the regulation of key nitrogen metabolic pathways in alfalfa by foliar spraying with nano-selenium.

Selenium promotes plant growth and improves nutritional quality, and the role of nano-selenium in alfalfa in regulating nutritional quality is unknown. In this study, using the N labeling method, it was found that nano-selenium could promote plant nitrogen metabolism and photosynthesis by increasing the light energy capture capacity and the activities of key enzymes of the nitrogen metabolism process, leading to an increase in alfalfa nitrogen accumulation and dry matter content. The transcriptome and metabolome revealed that nano-selenium mainly affected the pathways of 'biosynthesis of amino acids', 'starch and sucrose metabolism', 'pentose and glucuronate interconversions', 'pentose phosphate pathway', and 'flavonoid biosynthesis'.

Benzotrithiophene-based covalent organic frameworks for sensitive fluorescence detection and efficient removal of Ag from drinking water.

The simultaneous detection and removal of Ag from drinking water was crucial for preventing human health, while it was also extremely challenging due to bifunctional materials that combine both Ag adsorption and detection functions rarely being explored. In this study, a benzotrithiophene-based covalent organic framework (TAPA-BTT) was synthesized and applied to detect and remove Ag. TAPA-BTT exhibited high crystallinity, a large specific surface area, and good thermal stability.

A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging.

The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging.

Hydrothermal biochar enhances the photosynthetic efficiency and yield of alfalfa by optimizing soil chemical properties and stimulating the activity of microbial communities.

Hydrothermal biochar has demonstrated potential in enhancing crop growth by improving soil properties and microbial activity; however, its effectiveness varies with application rate, with excessive amounts potentially inhibiting plant growth. This study employed a pot experiment approach to compare varying application rates of hydrothermal biochar (ranging from 0 to 50 t/ha) and to analyze its effects on alfalfa biomass, photosynthetic efficiency, soil nutrient content, and microbial community composition. Biochar application increased alfalfa dry weight by 12.

Fully Flexible Humidity Sensor with Fast Response and High Responsivity Based on rGO/MoS for Human Respiration Monitoring and Nontouch Switches.

Humidity sensors have been widely used to monitor humidity in daily life, agriculture fields, and so on. However, conventional sensors are not suitable for wearable devices because of their large dimensions and rigid substrates. Hence, we report a fast response, highly sensitive, and fully flexible humidity sensor on a PI substrate based on the composite material of reduced graphene oxide (rGO)/MoS, with a response time of 0.

SMDFnet: Saliency multiscale dense fusion network for MRI and CT image fusion.

MRI-CT image fusion technology combines magnetic resonance imaging (MRI) and computed tomography (CT) imaging to provide more comprehensive and accurate image information. This fusion technology can play an important role in medical diagnosis and surgical planning. However, there are several issues with current MRI-CT image fusion, such as the presence of artifacts in both MRI and CT images, which may affect the quality and accuracy of the images during the fusion process.

Bibliometric analysis of research trends in agricultural soil organic carbon components from 2000 to 2023.

Soil organic carbon is a vital component of the soil carbon pool. Investigation of its composition and dynamics is crucial for enhancing carbon sequestration in soils and for stabilizing the global carbon cycle. In recent years, considerable research has focused on the interactions between soil organic carbon components and their responses to varied land use and agricultural practices.

Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy.

Peri-prosthesis osteolysis (PPO) represents the most severe complication of total joint arthroplasty (TJA) surgery and imposes the primary cause of prosthesis failure and subsequent revision surgery. Antiresorptive therapies are usually prescribed to treat PPO, especially for elderly people. Nevertheless, the efficacy of anti-osteoporotic medications remains constrained.

-deficient MDBK cell based on CRISPR/Cas9 technology for enhancing IBRV replication.

(IBR), characterized by acute respiratory lesions in cattle, is a major infectious disease caused by (BoAHV-1). Control of this disease is primarily depending on vaccination. Madin-Darby bovine kidney cells (MDBK) being the main host cells and the important production platform for IBR vaccines.

The study of halogen effect on the reactivity of the serine-targeting covalent warheads.

Halogens favorably contributes to the drug potency and metabolic stability via electrostatic interactions. Herein, the halogen effects on the reactivity of the halogenated 2,2,2-trifluoroacetophenones as serine-targeting covalent warheads were investigated. Our results showed that introducing halogen atoms, especially Cl or Br, into the phenyl scaffold would influence the electron density around the ring, which led to different time-dependent inhibition response to the target serine hydrolase (hCES1A).

Multi-Sensor Fusion for Wheel-Inertial-Visual Systems Using a Fuzzification-Assisted Iterated Error State Kalman Filter.

This paper investigates the odometry drift problem in differential-drive indoor mobile robots and proposes a multi-sensor fusion approach utilizing a Fuzzy Inference System (FIS) within a Wheel-Inertial-Visual Odometry (WIVO) framework to optimize the 6-DoF localization of the robot in unstructured scenes. The structure and principles of the multi-sensor fusion system are developed, incorporating an Iterated Error State Kalman Filter (IESKF) for enhanced accuracy. An FIS is integrated with the IESKF to address the limitations of traditional fixed covariance matrices in process and observation noise, which fail to adapt effectively to complex kinematic characteristics and visual observation challenges such as varying lighting conditions and unstructured scenes in dynamic environments.

The Influence of Matrix Resin Toughening on the Compressive Properties of Carbon Fiber Composites.

The study investigated the effects of a toughening agent and micron-sized toughening particles (TP) on the resin and carbon fiber-reinforced polymer (CFRP) composites, with a particular focus on compressive strength. The results showed that the addition of the toughening agent improved the overall mechanical properties of both the resin and CFRP but had a minor effect on the residual compressive strength (CAI) of CFRP after impact. Compared to the pure toughening agent, the addition of TP increased the CAI, GIC, and GIIC of CFRP by 74%, 35%, and 68%, respectively.

Danggui Liuhuang Decoction ameliorates endothelial dysfunction by inhibiting the JAK2/STAT3 mediated inflammation.

Ethnopharmacological Relevance: Vascular endothelial dysfunction (VED) is recognized as a key triggering diabetic vascular complications. Danggui Liuhuang Decoction (DGLHD) has shown potential in mitigating these complications. However, the clinical efficacy of DGLHD in enhancing endothelial function, as well as the molecular mechanisms underlying its alleviation of Type 2 Diabetes-Related Vascular Endothelial Dysfunction (T2DM-VED), remains insufficiently understood.