Evaluation of haematological changes in Plasmodium-berghei-infected mice administered with aqueous extract of Phyllantus amarus.

This study was designed to evaluate the changes in some hematological parameters of P-berghei-infected mice treated with aqueous extract of Phyllantus amarus, a plant that is used traditionally to treat malaria patients in some Nigerian communities. The aqueous extract of the leaves at 200, 400 and 600 mg kg(-1) body weight/day dose levels were used to treat the test groups immediately after infection for the suppressive test and 72 hours post infection for the curative test while a standard antimalarial drug, Artesunate, at a dose of 50 mg kg(-1) body weight was administered on the positive control group. The negative control group was left untreated.