Photooxidation Coupled Kabachnik-Fields and Bigenelli reactions for Direct Conversion of Benzyl alcohols to α-Amino Phosphonates and Dihydropyrimidones.

A tandem one-pot solvent free approach for the direct conversion of benzyl alcohols to α-amino phosphonates and dihydropyrimidones is reported. The method relies on a metal free photo-oxidation of benzyl alcohols to benzaldehydes under UV irradiation using ammonium perchlorate followed by Kabachnik-Fields and Biginelli reactions. The reaction conditions are moderate and metal free with good substrate scope.