Publications by authors named "Gazmend Elezi"
Article Synopsis
- Scientists studied how different kinds of flies sleep and found that desert flies sleep a lot more than common flies.
- The desert fly D. mojavensis has special sleep patterns that help it survive in tough conditions, like not having enough food.
- By disrupting their sleep with constant light, they discovered that these desert flies struggle more when they don't eat, showing that sleep is super important for their survival.
Article Synopsis
- Sleep patterns vary widely across species, and research on fruit flies helps understand these differences.
- A specific desert-adapted fly species shows a significant increase in sleep, indicating a high need for sleep while maintaining sleep homeostasis.
- This fly species also exhibits changes in sleep-related neurochemicals and displays sleep responses tied to survival in harsh conditions, suggesting it’s a valuable model for studying sleep strategies in extreme environments.
Glyphosate (GLY), a synthetic, nonselective systemic herbicide that is particularly effective against perennial weeds, is the most used weedkiller in the world. There are growing concerns over GLY accumulation in the environment and the attendant human health-associated risks, and despite increased attention in the media, GLY and its breakdown product aminomethylphosphonic acid (AMPA) remain elusive to many analytical strategies. Chemical derivatization coupled with high-performance liquid chromatography-mass spectrometry (HPLC-MS) addresses the challenge of quantifying low levels of GLY and AMPA in complex samples.
View Article and Find Full Text PDFSmall molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.
Proc Natl Acad Sci U S A
February 2023
Article Synopsis
- - The accumulation of alpha-synuclein in the brain is linked to Parkinson's disease and related disorders, making it a key target for treatment.
- - Researchers have discovered two small molecules, CNS-11 and CNS-11g, which can break down these harmful alpha-synuclein fibrils and reduce their toxicity in nerve cells.
- - These compounds not only work on lab-generated fibrils but also disassemble those from patients with multiple system atrophy, showing potential as effective therapies for treating synucleinopathies and being able to target brain tissue in mice.
Partial caecal necrosis - a rare cause of right-sided inferior abdominal pain and tenderness.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
March 2016
Introduction: Non-occlusive caecal infarction is a rare condition that has been described in association with a variety of clinical entities, generally due to a low-flow state, and has been reported to occur in association with chronic heart disease, open-heart surgery, certain drugs, and haemodialysis. The aim of this article is to describe the presentation, diagnosis and management of this unusual clinical problem.
Case Presentation: We report on an 84-year-old female with known chronic heart disease presenting with right lower abdominal quadrant pain, tenderness and leukocytosis.