[The quality of life and accessibility of medical care in persons with bronchial asthma in the Republic of Kazakhstan].

The access barriers to asthma basic treatment and medical care in many countries are an urgent problem and emphasize the need for population studies to examine the associated risk factors for barriers to health care, causes of severe exacerbations, disruption of life quality, and the development of preventive measures. The purpose of study was to evaluate the association of quality of life, access to medical care and emergency of severe exacerbation in persons with bronchial asthma in the Republic of Kazakhstan. The cross-sectional study was applied.

Levels of cytokines in drug hypersensitivity.

Introduction: Multiple drug intolerance is a serious complication of drug therapy and is an issue of allergology. The aim of the study was the investigation of cytokine status in patients with drug hypersensitivity and multiple drug hypersensitivity.

Material And Methods: 19 patients with multiple drug hypersensitivity, 34 patients with hypersensitivity to one drug, and 35 non-allergic subjects were involved.

[Cytologic parameters of broncho-alveolar lavage state in experimental animals exposed to mechanical rubber aerosol].

Cytologic studies covered broncho-alveolar lavage in animals exposed to mechanical rubber aerosol in subacute (2 months) and chronic (5 months) experiments. Under exposure to mechanical rubber aerosol the experimental animals developed disorders of lung protective mechanisms. Subacute dust inhalation in the experimental animals caused higher counts of neutrophils and degeneratively changed cells with increased functional activity of alveolar macrophages and neutrophils.

[Cytochemical parameters in nasal mucosal and peripheral blood cells in beryllium production workers].

Nasal mucosal and peripheral blood cells from beryllium production workers underwent cytochemical tests for catecholamines and phospholipids and the activity of esterase and lysosomal cationic proteins. The established peripheral blood metabolic changes reflect reduced cell resistance in response to poor occupational factors and may be used in the rapid hygienic assessment of cytotoxicity of toxic substances.

[Genotoxic effects caused in workers by beryllium compounds].

The author represents results of studying genotoxic effects caused in workers by beryllium compounds. Increasing age and length of service apperared to correlate with higher level of chromosomal aberration in peripheral WBC. Findings are that obtaining beryllium and its compounds is associated with changed level of chromosomal damages.

[Cytochemical parameters in nasal mucosal and peripheral blood cells in beryllium production workers].

Nasal mucosal and peripheral blood cells from beryllium production workers underwent cytochemical tests for catecholamines and phospholipids and the activity of esterase and lysosomal cationic proteins. The established peripheral blood metabolic changes reflect reduced cell resistance in response to poor occupational factors and may be used in the rapid hygienic assessment of cytotoxicity of toxic substances.