Publications by authors named "Gayle van der Kraaij"
Article Synopsis
- The study investigates how combining methotrexate with adalimumab treatment affects drug concentration and response in psoriasis patients.
- A population PK-PD model was created from data collected over 49 weeks from 59 patients, revealing that methotrexate cotreatment reduces the development of antidrug antibodies, which can enhance the effectiveness of adalimumab.
- Overall, the findings suggest that using methotrexate alongside adalimumab can lead to better treatment outcomes by increasing adalimumab levels and potentially improving clinical responses.
Article Synopsis
- Anti-drug antibodies (ADA) can form in patients treated with adalimumab (ADL), potentially reducing its effectiveness; using methotrexate (MTX) alongside ADL seems to lower ADA levels and improve outcomes in rheumatologic diseases.
- A study was conducted in the Netherlands and Belgium to compare the long-term effectiveness and safety of ADL combined with MTX versus ADL alone over three years in patients with moderate to severe plaque psoriasis.
- Results showed no significant difference in drug survival between the two groups, even though the ADL + MTX group had a trend towards longer survival; however, adverse events led to common discontinuation in the combination group.
[A man with a rare disfiguring cutaneous manifestation of sarcoidosis].
Ned Tijdschr Geneeskd
July 2022
A 42-year-old man with no relevant medical history presented with a painless, red, disfiguring skin lesion located on the nose. He was diagnosed with lupus pernio, a rare, cutaneous subtype of sarcoidosis which is relatively resistant to therapy and is associated with systemic sarcoidosis.
View Article and Find Full Text PDFImportance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.
Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.
Article Synopsis
- Adalimumab is often used with methotrexate (MTX) for better treatment of rheumatoid arthritis and this study aimed to explore its effectiveness for chronic plaque psoriasis.
- The trial compared two groups: one receiving adalimumab alone and the other receiving adalimumab with MTX, analyzing factors like drug survival, response rates, and levels of antidrug antibodies.
- Results showed that the combination therapy led to fewer antidrug antibodies and a trend towards improved treatment response and drug survival, with no significant safety issues reported.
In shared decision making (SDM) patients and physi-cians make treatment decisions together based on the best available evidence and the values and preferences of patients. SDM is very suitable for use in dermatological practice, but is infrequently applied by dermatologists. To support the application of SDM in dermatology we developed Decision Cards: 1-page overviews of possible treatment options, for use during a patient-physician consultation.
View Article and Find Full Text PDFInterleukin 17-antagonist secukinumab demonstrated high efficacy for treatment of psoriasis in randomized controlled trials. However, performance in daily practice may differ from trials. Drug survival is a comprehensive outcome covering effectiveness and safety, suitable for analyses of daily practice.
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