Understanding the implementation of a multidisciplinary intervention using a suite of prescribing safety indicators to improve medication safety in prison healthcare settings: a qualitative study.

Objectives: Patients residing in prisons are a vulnerable group with more complex health needs and higher prevalence of inappropriate prescribing than the general population. Overcrowding in prisons, inadequate staffing levels, diversion of medication and substance misuse present challenges to prison healthcare. Interventions that use prescribing safety indicators are one way of helping to reduce the risk of harm by identifying patients at risk of potentially hazardous prescribing.

Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free mice.

Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that causes hemorrhagic colitis and acute renal failure. We used a germ-free mouse model to investigate the role of host factors, Shiga toxin 2 (Stx2), and bacterial strain in disease due to EHEC. Germ-free male and female Swiss-Webster mice that were 3 days to 12 weeks old were orally inoculated with 1 of 10 EHEC strains or derivatives of two of these strains with Stx2 deleted.