Capturing the incidence of patient agitation amongst conscious sedation ERCPs and the impact on therapeutic outcomes.

Background: Completing advanced endoscopic procedures such as endoscopic retrograde cholangiopancreatography (ERCP) under conscious sedation is challenging. International recommendations favor enhanced sedation (e.g.

Rectal neuroendocrine tumours and the role of emerging endoscopic techniques.

Rectal neuroendocrine tumours represent a rare colorectal tumour with a 10 fold increased prevalence due to incidental detection in the era of colorectal screening. Patient outcomes with early diagnosis are excellent. However endoscopic recognition of this lesion is variable and misdiagnosis can result in suboptimal endoscopic resection with subsequent uncertainty in relation to optimal long-term management.

A prospective evaluation of fatty pancreas by using EUS.

Background: Fatty liver is associated with obesity, diabetes, hyperlipidemia, and the metabolic syndrome. The pathophysiology of fatty pancreas is poorly understood, but it may be closely related to fatty liver.

Objective: The aim of our study was to determine the prevalence of fatty pancreas and risk factors associated with its development.

A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer.

Background: NET1, a RhoA guanine exchange factor, is up-regulated in gastric cancer (GC) tissue and drives the invasive phenotype of this disease. In this study, we aimed to determine the role of NET1 in GC by monitoring the proliferation, motility and invasion of GC cells in which NET1 has been stably knocked down. Additionally, we aimed to determine NET1-dependent transcriptomic events that occur in GC.

Interventions for prevention of post-operative recurrence of Crohn's disease.

Background: Recurrence of Crohn's disease is common after intestinal resection. A number of agents have been studied in controlled trials with the goal of reducing the risk of endoscopic or clinical recurrence of Crohn's disease following surgery.

Objectives: To undertake a systematic review of the use of medical therapies for the prevention of post-operative recurrence of Crohn's disease

Search Strategy: MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify relevant studies.