Medical records for animals used in research, teaching, and testing: public statement from the American College of Laboratory Animal Medicine.

Medical records are considered to be a key element of a program of adequate veterinary care for animals used in research, teaching, and testing. However, prior to the release of the public statement on medical records by the American College of Laboratory Animal Medicine (ACLAM), the guidance that was available on the form and content of medical records used for the research setting was not consistent and, in some cases, was considered to be too rigid. To address this concern, ACLAM convened an ad hoc Medical Records Committee and charged the Committee with the task of developing a medical record guideline that was based on both professional judgment and performance standards.

The effect of commonly used vehicles on canine hematology and clinical chemistry values.

Drug metabolism and pharmacokinetic (DMPK) studies are an important phase in drug discovery research. Compounds are administered via the intravascular or extravascular routes to animals to calculate various pharmacokinetic parameters. An important step in this process is dissolving the novel compound in a safe vehicle.

Evaluation of Injectable Anesthetics for Major Surgical Procedures in Guinea Pigs.

Anesthetizing guinea pigs is difficult with varying outcomes. The primary purpose of the study reported here was to evaluate six injectable anesthetic regimens for use in guinea pigs and assess the depth of anesthesia and, thus, their effectiveness in terms of their use for major surgical procedures. Other variables that were measured and evaluated included time from injection until onset of anesthesia, duration of anesthesia, depth of anesthesia, and vital signs (i.

Hospital-based diagnosis of hemorrhagic fever, encephalitis, and hepatitis in Cambodian children.

Surveillance was conducted for three clinical syndromes (hemorrhagic fever, encephalitis, and hepatitis) in Cambodian children admitted to the National Pediatric Hospital in Phnom Penh from July 1996 through September 1998. Acute- and convalescent-phase sera, and cerebrospinal fluid, when applicable, underwent diagnostic evaluation for infections with Dengue virus (DENV), Japanese encephalitis virus (JEV), and Hepatitis A, B, C, and E viruses. Of 621 children admitted with hemorrhagic fever, 499 (80%) were confirmed to have either primary or secondary DENV infection.