At-a-glance - Conceptualizing a framework for the surveillance of physical activity, sedentary behaviour and sleep in Canada.

The Public Health Agency of Canada (PHAC) has modernized its approach to physical activity surveillance by broadening its scope to include sedentary behaviour and sleep. The first step was to develop a conceptual framework which covers the full spectrum of physical movement from moderate-to-vigorous intensity physical activity (MVPA) and light intensity physical activity (LPA) to sedentary behaviour and sleep. The framework accounts for the environments in which these behaviours take place (home, work/school, transportation, and community), and applies a socioecological approach to incorporate individual factors and broader built, social, and societal environmental indicators.

Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds.

A series of 1,2,3-triazole coronopilin congeners have been designed and synthesized by employing click chemistry approach starting from parthenin and evaluated for their cytotoxicity against a panel of six human cancer cell lines (PC-3, THP-1, HCT-15, HeLa, A-549 and MCF-7). While many compounds exhibited significant anticancer activity, compound 3a, was found to be the most promising analogue in this series with IC50 values of 3.1 μM on PC-3 cell line.