Indian J Otolaryngol Head Neck Surg
February 2025
To determine the level of disability in patients suffering from tinnitus using the Tinnitus Handicap Inventory (THI) score, to evaluate the changes in otoacoustic emissions in a patient with tinnitus and evaluate the co-relation of the Tinnitus Handicap Inventory score with the Otoacoustic emission result This is an observational study done over a period of 6 months, in which patients aged more than 18 years who presented to the ENT OPD of our institute with complaints of tinnitus were considered for inclusion in the study. Patients with primary tinnitus, who consented to be part of the study were assessed for handicap caused by tinnitus using the Tinnitus Handicap Inventory (THI) score. All patients were subjected to Pure Tone Audiometry (PTA) and Screening OAE to look for the "Pass" or "Refer" in the OAE result.
View Article and Find Full Text PDFIntroduction: To evaluate the enamel abrasion effects of soft, ultra-soft, and nano-bristle toothbrushes using atomic force microscopy (AFM) to guide toothbrush selection for optimal enamel preservation.
Methods: This in vitro study involved 45 extracted human teeth (central and lateral incisors), randomly assigned to three groups (n=15 each): Group I (nano-bristle), Group II (ultra-soft bristle), and Group III (soft bristle). Each specimen underwent 10,000 brushing cycles with a standardized 2 N force to simulate one year of brushing.
Background: Periodontal disease is a major contributing factor to tooth loss and can significantly impact overall health. Traditional periodontal therapy typically involves mechanical debridement to remove plaque and calculus, along with the use of antimicrobial agents to reduce bacterial load. Licorice () has a long history of use in traditional medicine for treating various ailments since it contains glycyrrhizin, glabridin, liquiritin, and flavonoids, which possess anti-inflammatory, antioxidant, and antimicrobial activities.
View Article and Find Full Text PDFAim To evaluate the biocompatibility of ethanolic extract of (bael/vilvam) leaves with gingival fibroblast cells. Materials and methods Commercially available bael leaves were used to produce a herbal ethanolic extract using the cold percolation technique. Evaluation of cytotoxicity of the bael leaf extract (BLE) on fibroblast cell line at six different concentrations (200µl/ml, 100µl/ml, 50µl/ml, 25µl/ml, 12.
View Article and Find Full Text PDFAim This study aims to assess patient motivation during implant therapy using the newly developed implant treatment motivation scale. Materials and methods A questionnaire study was conducted, consisting of 15 questions designed to explore the motivating factors behind patients' decision to undergo implant therapy. A total of 50 patients about to undergo implant treatment at the Departments of Periodontology, Oral and Maxillofacial Surgery, and Prosthodontics participated in the study.
View Article and Find Full Text PDFBackground: Periodontal disease is a host-mediated inflammation caused due to microbial challenge. Hence, mechanisms involving the control of host-associated mediators can be a potential target. The conventional nonsurgical periodontal treatment modality includes scaling and root planing (SRP), which is often combined with adjunctive chemical plaque control agents for effective disease control.
View Article and Find Full Text PDFThe incidence of cancer is increasing worldwide in a life-threatening manner. In such a scenario, the development of anti-cancer drugs with minimal side effects and effective drug delivery systems is of paramount importance. Doxorubicin (DOX) is one of the powerful anti-cancer drugs from the chemical family anthracycline, which is used to treat a wide variety of cancers, including breast, prostate, ovarian, and hematological malignancies.
View Article and Find Full Text PDFBackground: The left ventricle segmentation (LVS) is crucial to the assessment of cardiac function. Globally, cardiovascular disease accounts for the majority of deaths, posing a significant health threat. In recent years, LVS has gained important attention due to its ability to measure vital parameters such as myocardial mass, end-diastolic volume, and ejection fraction.
View Article and Find Full Text PDFOral submucous fibrosis (OSMF) is a potentially malignant disorder with no permanent cure that affects the quality of life due to trismus. Computational pharmacology has accelerated the discovery of drug candidates for the treatment of incurable diseases. The present study aimed to screen the compounds of the miracle herb with drug-likeness properties based on the absorption, distribution, metabolism, and excretion (ADME) properties.
View Article and Find Full Text PDFTo reduce TB deaths, Tamil Nadu, a southern Indian state, implemented the first state-wide differentiated TB care strategy starting April 2022. Triage-positive severely ill patients are prioritised for comprehensive assessment and inpatient care. Routine program data during October-December 2022 revealed that documentation of total score after comprehensive assessment was available in only 39%, possibly indicating poor quality of comprehensive assessment.
View Article and Find Full Text PDFDioxins and dioxin-like polychlorinated biphenyls are a group of lipophilic compounds classified under persistent environmental pollutants (POPs). Significant sources of dioxin emissions include industrial effluents, open burning practices, and biomedical and municipal waste incinerators. These emissions will enter the food chain and accumulate in animal-origin foods (AOFs).
View Article and Find Full Text PDFIn India, the incidence of mucormycosis reached high levels during 2021-2022, coinciding with the COVID-19 pandemic. In response to this, we established a multicentric ambispective cohort of patients hospitalised with mucormycosis across India. In this paper, we report their baseline profile, clinical characteristics and outcomes at discharge.
View Article and Find Full Text PDFHerein, we prepare a new array of -(α-furanyl) alkyl sulfoximines a gold catalyzed reaction of enynone with sulfoximine in moderate to very good yields. The reaction involves Michael addition of sulfoximine to enynone, followed by intramolecular cyclization. The presence of two chiral centres led to the formation of a mixture of diastereomers approximately in a 1 : 1 ratio.
View Article and Find Full Text PDFJustification: The diagnosis of Down syndrome (DS) is easily made clinically but the management is multi-disciplinary and life-long. There is no standard protocol available for its management in India.
Process: A committee was formed under the Indian Academy of Pediatrics (IAP) chapter of Neuro developmental pediatrics consisting of 20 experts working in the related field.
Objective: The review aims to comprehend various factors engaged in the alteration of molecular events resulting in Oral submucous fibrosis (OSMF) and its malignant transformation.
Design: Literature pertinent to pathways involved in OSMF were explored in databases such as PubMed, Scopus and Google Scholar. The relevant literature was reviewed and critically appraised in this narrative review.
Alagille Syndrome (ALGS) is a rare, autosomal dominant inherited disorder that causes abnormalities of liver, eye, heart, skeleton and distinctive facial appearance. ALGS is caused by mutation in one of two genes: JAG1 and NOTCH2. There are some reports of Hearing Loss in patients with ALGS raising the possibility of involvement of both structural components of middle ear and sensorineural components of the inner ear.
View Article and Find Full Text PDFDue to the workload and lack of a critical mass of trained operational researchers within their ranks, health systems and programmes may not be able to dedicate sufficient time to conducting operational research (OR). Hence, they may need the technical support of operational researchers from research/academic organisations. Additionally, there is a knowledge gap regarding implementing differentiated tuberculosis (TB) care in programme settings.
View Article and Find Full Text PDFThe nitrogen-fixing bacterium has great prospects in replacing synthetic fertilizers with biofertilizers for plant growth. It would be a useful tool in eradicating chemical fertilizers from use. Five nitrogen-fixing bacteria were isolated from the Tea and Groundnut rhizosphere soil out of which RSKVG 02 proved to be the best.
View Article and Find Full Text PDFPotassium (K) and phosphorus (P) are the important macronutrients needed for the plant development, but it is widely present in an insoluble form for the plant's uptake. In order to increase the productivity, biofertilisers play crucial role in plant growth enhancement. Our present work focused to isolate potassium-phosphate solubilizing bacteria from the agricultural soil of tomato cultivated soil.
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