Publications by authors named "Gayane Mkrtchyan"
Comparative characteristics of the genetic structure of the Syrian cattle breed compared to Holstein and Aberdeen-Angus breeds.
Mohammad Almohammad Alsalh Anatoly Bakai Feyzullah Ramazanovich Feyzullaev Ferdaus Rafailovna Bakai Tatyana Viktorovna Lepekhina Gayane Mkrtchyan
J Adv Vet Anim Res
June 2021
Objectives: The objective of this study was to perform a comparative analysis of allelic diversity to reveal population-genetic characteristics of animal breeds, namely Shami (SH), Holstein (HLS), and Aberdeen-Angus (A-A).
Materials And Methods: The genetic materials of SH breed animals represented by wool with hair follicles were collected from 39 SH heads in Syria. Also, genetic materials of HLS breed of American selection ( = 55, HLS) and bulls and cows of A-A breed bred at breeding enterprises in Russia ( = 30, A-A) were collected.
Article Synopsis
- The study examined how two strains of African swine fever (ASF) viruses affect the activation of porcine alveolar macrophages (AM), noting differences in immune response.
- Cells infected with the virulent ASFV-Georgia2007 showed unique M1 polarization and changes in morphology, resulting in lower synthesis of certain interferons compared to those infected with the attenuated strain ASFV-BA71V.
- The findings suggest that the more virulent ASFV-Georgia2007 reduces the antiviral response of AM, indicating that the evolutionary decrease of ASFV virulence is linked to changes in host immune system regulation.