Publications by authors named "Gayane L Mkrtchyan"
Article Synopsis
- The study examined how two strains of African swine fever (ASF) viruses affect the activation of porcine alveolar macrophages (AM), noting differences in immune response.
- Cells infected with the virulent ASFV-Georgia2007 showed unique M1 polarization and changes in morphology, resulting in lower synthesis of certain interferons compared to those infected with the attenuated strain ASFV-BA71V.
- The findings suggest that the more virulent ASFV-Georgia2007 reduces the antiviral response of AM, indicating that the evolutionary decrease of ASFV virulence is linked to changes in host immune system regulation.