Publications by authors named "Gayane G Poghosyan"

Anisotropic silver nanoparticles sensitized by various lectins were applied for detection of yeast (Saccharomyces cerevisiae) which was used as a model of fungal cells. It was shown that high concentrations of yeast cells have stabilized silver nanoparticles, preventing their aggregation in the presence of NaCl whereas at low concentrations of cells, the salt has induced aggregation of nanoparticles with drastic changes in optical spectra. These changes depend on cell concentration and permit the detection of cells in the range from 3.

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In the article, presence of antibodies to protein components of oxidized human donor plasma was demonstrated. It was shown that normal plasma oxidized by CuCl, FeSO, or potassium ferricyanide acquired ability to bind with human IgG-sensitized polystyrene latex particles and colloidal gold nanoparticles. Ability of these antibodies to bind to oxidized components strongly depends on time of oxidation.

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Antibodies to oxidized lipoproteins are useful markers for diagnosis and prognosis of some heart diseases. Low density lipoproteins (LDL) were purified from human plasma and were oxidized by CuCl. They were immobilized on anisotropic silver nanoparticles with tunable plasmon resonance band and were applied for detection of appropriate antibodies in sera of patients with stenosis.

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Efficacy of anisotropic silver nanoparticles sensitized with wheat germ agglutinin (WGA) and Lens culinaris agglutinin (LCA) was studied for detection of Staphylococcus aureus and Escherichia coli. It was demonstrated that interaction of these nanoparticles with bacteria stabilizes them and prevents their aggregation upon addition of sodium chloride; such stabilization depends on bacteria concentration. High concentration of bacteria results in higher stabilization whereas low concentration leads to aggregation of nanoparticles.

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