ppHiC: Interactive exploration of Hi-C results on the ProteinPaint web portal.

The ProteinPaint Hi-C tool (ppHiC) facilitates web-based visualization and collaborative exploration of Hi-C data, a vital resource for understanding three-dimensional genomic structures. ppHiC allows researchers to easily analyze large Hi-C datasets on a web browser without requiring the computational expertise that has heretofore limited access to this complex genomic data. The platform is compatible with multiple Hi-C data versions and boasts a highly customizable interface, including a configuration panel for the precise adjustment of key visualization parameters.

ppBAM: ProteinPaint BAM track for read alignment visualization and variant genotyping.

Summary: ProteinPaint BAM track (ppBAM) is designed to assist variant review for cancer research and clinical genomics. With performant server-side computing and rendering, ppBAM supports on-the-fly variant genotyping of thousands of reads using Smith-Waterman alignment. To better visualize support for complex variants, reads are realigned against the mutated reference sequence using ClustalO.

Author Correction: Exploring the coronavirus pandemic with the WashU Virus Genome Browser.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cell-Type Transcriptomes of the Multicellular Green Alga Yield Insights into the Evolutionary Origins of Germ and Somatic Differentiation Programs.

Germ-soma differentiation is a hallmark of complex multicellular organisms, yet its origins are not well understood. is a simple multicellular green alga that has recently evolved a simple germ-soma dichotomy with only two cell-types: large germ cells called gonidia and small terminally differentiated somatic cells. Here, we provide a comprehensive characterization of the gonidial and somatic transcriptomes of to uncover fundamental differences between the molecular and metabolic programming of these cell-types.

Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation.

Patterning of a multicellular body plan involves a coordinated set of developmental processes that includes cell division, morphogenesis, and cellular differentiation. These processes have been most intensively studied in animals and land plants; however, deep insight can also be gained by studying development in simpler multicellular organisms. The multicellular green alga Volvox carteri (Volvox) is an excellent model for the investigation of developmental mechanisms and their evolutionary origins.