Publications by authors named "Gavin X McLeod"
A healthy 57-year-old man present to outpatient ophthalmological services in southwestern Connecticut with a 16-month history of unilateral periorbital pain, photophobia, and progressively decreasing visual acuity in his left eye. Prior extensive work-up for uveitis in his home state of Mississippi had yielded no etiology for his symptoms, and empiric therapy with glucocorticoid eye drops had not halted their decline. Fundoscopic examination demonstrated total combined retinal detachment of the left eye.
View Article and Find Full Text PDFArticle Synopsis
- * Initial tests showed elevated inflammatory markers, kidney damage, and lung issues, but brain tests did not reveal any clear cause.
- * Eventually, he was found to be seropositive for Borrelia miyamotoi, highlighting the importance of considering tick-borne diseases in cases of relapsing fever, especially in New England.
Mural endocarditis is a rare subclass of infective endocarditis (IE) associated with intra-cardiac tumors, prosthesis, valvular vegetation's, or structural abnormalities such as ventricular septal defects. Bacteria classified as HACEK ( species, , and ) are rare causes of IE found in only 1.3% to 10% of cases.
View Article and Find Full Text PDFThe major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Science
December 2010
Article Synopsis
- Researchers conducted a genome-wide association study focusing on HIV-1 controllers and progressors to understand genetic factors influencing chronic viral infections.
- They discovered over 300 significant single-nucleotide polymorphisms (SNPs) specifically within the major histocompatibility complex (MHC), emphasizing its importance for infectious diseases.
- Key findings indicate that specific amino acids in HLA proteins, especially HLA-B and HLA-C, significantly influence the interaction between HLA and viral peptides, affecting the control of HIV infection.
Impact of an Adherence Program on the Health and Outlook of HIV-Infected Patients Failing Antiretroviral Therapy.
J Int Assoc Physicians AIDS Care (Chic)
July 2005
Background: We prospectively studied the impact of an adherence counselor on the outcome of patients failing antiretroviral therapy because of nonadherence.
Methods: Forty-six patients, identified as chronically nonadherent were enrolled. Individual attention was provided using the information, motivation and behavioral methodology.