Publications by authors named "Gavin Shueng Wai Chan"
Article Synopsis
- STAT6 is a key transcription factor involved in allergic inflammation, and researchers identified 16 patients from 10 families across three continents with severe allergic conditions related to its dysfunction.
- These patients exhibited various symptoms like early-onset immune issues, treatment-resistant skin conditions, asthma, and food allergies, all linked to rare mutations in the STAT6 gene that lead to a gain-of-function phenotype.
- The study suggests that these mutations cause a novel autosomal dominant allergic disorder and highlights the successful use of the anti-IL-4Rα antibody, dupilumab, as a precision treatment for managing symptoms and improving immune responses.
A 47-year-old woman was admitted to the hospital for an episode of hemoptysis. She coughed out small amount of clotted blood the morning of admission. She had no other symptoms on further review.
View Article and Find Full Text PDFRapid reduction of viruria and stabilization of allograft function by fusidic acid in a renal transplant recipient with JC virus-associated nephropathy.
Infection
October 2015
JC virus (JCV)-associated nephropathy has been increasingly recognized as a cause of allograft dysfunction with graft loss in renal transplant recipients. Like many other opportunistic viral infections in transplant recipients, there are currently limited therapeutic options for this condition. Fusidic acid has previously been reported to exhibit antiviral activity against JCV in in vitro assays.
View Article and Find Full Text PDFBackground: Since the first description of extranodalfollicular dendritic cell sarcoma in 1994, there has been a gradual increase in understanding of the morphologic features and clinical presentation of this tumor. However, difficulties persist in making cytologic diagnosis.
Cases: Two cases of follicular dendritic cell sarcoma with fine needle aspiration cytology (FNAC) findings were reported.
Heavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported.
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- Lethal multiple pterygium syndrome is a rare genetic disorder, typically diagnosed based on specific prenatal ultrasound findings.
- Previous studies indicated that diagnosis usually occurs in the later stages of pregnancy, but this report shows that it can be identified as early as the first trimester.
- The case presented highlights unique sonographic and postmortem features of a fetus affected by the syndrome at 13 weeks of gestation.
Granulomatous appendicitis can be idiopathic or due to a number of specific causes. Idiopathic granulomatous appendicitis is regarded as a separate disease entity and usually has a benign course. We report on a case of granulomatous appendicitis, which progressed to fulminant Crohn's colitis shortly after appendicectomy.
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