Publications by authors named "Gavin P R Clunie"
Background: There is considerable practice variation in labelling, diagnosis and treatment of adults with sterile bone inflammation. We developed a expert consensus recommendations on the disease definition, diagnosis and treatment of this rare condition.
Methods: Systematic literature review and Grading of Recommendations, Assessment, Development and Evaluations-based appraisal of evidence, two Delphi surveys and three digital and in-person consensus meetings with a multidisciplinary expert panel and patient representatives.
Article Synopsis
- Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disease caused by tumors secreting excess fibroblast growth factor 23 (FGF23), leading to low phosphate levels and subsequent bone and muscle issues.
- Diagnosing TIO can be difficult due to non-specific symptoms like bone pain and fractures, as well as the elusive nature of the tumors that often go undetected.
- Effective management relies on quicker diagnosis and treatment options, emphasizing the need for improved awareness and understanding of TIO within healthcare systems.