Normal nerve striations are altered in the trembler-J mouse, a model of Charcot-Marie-Tooth disease.

Introduction: This study was initiated because it was noted that the peripheral nerves of Trembler-J mice (a model of human Charcot-Marie-Tooth disease) appear to lack normal striations.

Methods: We performed confocal microscopy of whole sciatic nerves and tested the effect of axial stress on impulse conduction.

Results: We found that the axons of mutant mice were longer than those of the wild-type (1.