Robust enhancement of motor sequence learning with 4 mA transcranial electric stimulation.

Background And Objectives: Motor learning experiments with transcranial direct current stimulation (tDCS) at 2 mA have produced mixed results. We hypothesize that tDCS boosts motor learning provided sufficiently high field intensity on the motor cortex.

Methods: In a single-blinded design, 108 healthy participants received either anodal (N = 36) or cathodal (N = 36) tDCS at 4 mA total, or no stimulation (N = 36) while they practiced a 12-min sequence learning task.

Cutaneous sensation of electrical stimulation waveforms.

Background: Skin sensation is the primary factor limiting the intensity of transcranial electrical stimulation (tES). It is well established that different waveforms generate different sensations, yet transcranial stimulation has been limited to a relatively small number of prototypical waveforms.

Objective: We explore whether alternative stimulation waveforms could substantially reduce skin sensation and thus allow for stronger intensities in tES.