Publications by authors named "Gauthier Noppe"

Article Synopsis
  • Immunochemotherapy using PD-1/PD-L1 antibodies combined with chemotherapeutic agents is a growing cancer treatment, but optimal drug combinations are still being researched.
  • This study focuses on how the chemotherapeutic drugs gemcitabine and cisplatin affect the effectiveness of PD-1 antibody treatment in cancers driven by the K-ras mutation, which often overexpresses PD-L1.
  • Results indicate that gemcitabine reduces the effectiveness of PD-1 antibodies by inhibiting CD8 T cell infiltration, while cisplatin enhances the treatment’s efficacy by activating CD8 T cells, suggesting that choosing the right chemotherapy drug is crucial for successful immunochemotherapy.
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Cardiac fibroblasts (CF) are crucial in left ventricular (LV) healing and remodeling after myocardial infarction (MI). They are typically activated into myofibroblasts that express alpha-smooth muscle actin (α-SMA) microfilaments and contribute to the formation of contractile and mature collagen scars that minimize the adverse dilatation of infarcted areas. CF predominantly express the α1 catalytic subunit of AMP-activated protein kinase (AMPKα1), while AMPKα2 is the major catalytic isoform in cardiomyocytes.

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Ezrin, radixin, and moesin possess a very similar structure with a C-terminal actin-binding domain and a N-terminal FERM interacting domain. They are known to be involved in cytoskeleton organization in several cell types but their function in vascular smooth muscle cells (VSMC) is still unknown. The aim of this study was to investigate the role of ERM proteins in cell migration induced by PDGF, a growth factor involved in pathophysiological processes like angiogenesis or atherosclerosis.

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Aims: Mesenchymal stem cells (MSCs) are widely used for cell therapy, particularly for the treatment of ischaemic heart disease. Mechanisms underlying control of their metabolism and proliferation capacity, critical elements for their survival and differentiation, have not been fully characterized. AMP-activated protein kinase (AMPK) is a key regulator known to metabolically protect cardiomyocytes against ischaemic injuries and, more generally, to inhibit cell proliferation.

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Aims: The metabolic syndrome (MS) leads to myocardial fibrosis (MF) and diastolic dysfunction. Statins have proven beneficial effects in MS, but their impact on cardiac remodelling is uncertain. We examined the effects and mechanisms of chronic statin treatment on cardiac remodelling, e.

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