Publications by authors named "Gautam V Daftary"
Objective: To compare the efficacy and safety of recombinant anti-D (R-anti-D) with conventional polyclonal anti-D (Poly anti-D) in preventing maternal-fetal rhesus D (RhD) alloimmunization and to investigate the immunogenicity of R-anti-D.
Methods: This was a randomized, open-label, multi-center clinical trial conducted in RhD-negative pregnant women who did not receive antenatal anti-D who delivered RhD-positive babies and showed negative indirect Coombs tests (ICTs) at baseline. The women were randomized in a 2:1 ratio to R-anti-D or Poly anti-D groups and were administered 300 mcg (IM) of the corresponding drug within 72 hours of delivery.
Article Synopsis
- A new recombinant human chorionic gonadotropin (r-hCG) was developed in India, and this study compared its effectiveness and safety with Ovitrelle for inducing ovulation in women undergoing intrauterine insemination (IUI).
- A total of 217 women aged 20-37 were randomly assigned to receive either the new r-hCG or Ovitrelle after ovarian stimulation, with the main focus on comparing ovulation and pregnancy rates, as well as monitoring adverse events.
- Results showed similar ovulation rates (85.4% for r-hCG vs. 78.1% for Ovitrelle) and pregnancy rates (11.8% vs. 12.3%), along with a low