Publications by authors named "Gautam Mazumder"
Article Synopsis
- Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health issue, with specific regions like South-East Asia, Africa, and the Western Pacific reporting the highest new cases.
- The rise of multi-drug-resistant (MDR) TB has prompted researchers to explore natural alternatives, such as phytochemicals, which could offer a safer and more effective treatment option than current synthetic drugs.
- Traditional medicinal systems like Ayurveda and Siddha utilize various plants known for their beneficial compounds, and ongoing research focuses on mapping molecular approaches to enhance the effectiveness of these natural remedies against MDR TB.
Neurodegenerative diseases are emerging as a global health concern in the current scenario, and their association with mitochondrial defects has been a potential area of research. Mitochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to be primarily triggered by mitochondrial malfunction.
View Article and Find Full Text PDFReconciling the Gap between Medications and their Potential Leads: The Role of Marine Metabolites in the Discovery of New Anticancer Drugs: A Comprehensive Review.
Curr Pharm Des
January 2024
Article Synopsis
- * Advancements in genomic and bioinformatics research have enhanced our understanding of the complex genetic interactions that contribute to cancer, but challenges like epigenetic resistance remain obstacles in effective treatment development.
- * Although many anticancer drugs stem from natural sources, particularly plants and microorganisms, there is a notable gap in research on algae-based treatments, prompting a review of their potential as innovative therapeutic options.
Background: The compounds containing heterocyclic cores with O, N and/or S atoms are bioactive and valuable molecules in the field of drug discovery and development. There are several applications in different areas for the molecules having oxadiazole moiety in their structures viz. herbicides and corrosion inhibitors, electron-transport materials, polymers and luminescent materials.
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