Publications by authors named "Gaurav V Chitode"
Int J Neurosci
October 2024
Article Synopsis
- Empagliflozin, an SGLT2 inhibitor, was tested for its antidepressant effects in diabetic rats using a model that simulates neuroinflammation-mediated depression after performing olfactory bulbectomy (OBX) surgery.
- The study involved treating the rats with oral doses of empagliflozin, metformin, and clomipramine over 14 days, and measuring changes in behavior and antioxidant levels.
- Results indicated that empagliflozin improved depressive behaviors and restored antioxidant levels in the brain, suggesting it may help treat depression linked to neuroinflammation and oxidative stress.
