Publications by authors named "Gaurav N Pathak"
Article Synopsis
- * The disease is complex and involves immune responses where CD8+ T-cells target melanocytes, and various treatment strategies include phototherapy, grafting, and new drugs like JAK-STAT inhibitors.
- * Future research should focus on exploring alternative drug targets, genetic factors, and immune cell treatments, potentially leading to more effective and lasting solutions for vitiligo.
Introduction: Exosomes are extracellular vesicles that transport bioactive substances during normal and abnormal cellular physiological processes. The unique properties of exosomes can be exploited for use as biomarkers and targeted drug delivery vehicles, and are, for this reason, gaining increasing attention in the field of dermatology. This review aims to synthesise the existing evidence supporting exosomes in regenerative and cosmetic dermatology.
View Article and Find Full Text PDFPemphigus represents a spectrum of potentially life-threatening autoimmune-mediated skin blistering conditions caused by antibody production against desmoglein 1 and 3 (anti-DSG 1 and 3) in keratinocytes. Greater than 50% of pemphigus patients experience relapse, which complicates long-term medical management, including risks associated with re-treatment and complications such as infection and dehydration. This review aims to elucidate mechanisms, risk factors, and medications associated with pemphigus relapse.
View Article and Find Full Text PDFArticle Synopsis
- - Pemphigus is a serious autoimmune blistering disease that significantly impacts patients' health and quality of life, prompting numerous clinical trials to explore effective treatments.
- - A review of 53 randomized clinical trials showed that the Pemphigus Disease Area Index is the most commonly used disease severity measure, particularly gaining traction after 2015, while less popular methods have declined.
- - There's a growing trend toward including Quality of Life (QoL) measurements in clinical trials, although only a quarter currently assess it; standardizing these measures can improve data interpretation and clinical relevance over time.
Objective: This article reviews clinical trial data that assesses the safety, efficacy, and clinical application of spesolimab, an interleukin-36 (IL-36) blocker, for the treatment of generalized pustular psoriasis (GPP).
Data Sources: A review of the literature was conducted using the search terms: "spesolimab," "BI 655130," and "spevigo" in MEDLINE (PubMed) and Clinicaltrials.gov from January 1, 1950 to October 31, 2023.
Introduction And Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH) and, ultimately, cirrhosis. Clostridioides difficile is the most common nosocomial cause of diarrhea and is associated with worse clinical outcomes in other liver diseases, including cirrhosis, but has not been extensively evaluated in concomitant NAFLD/NASH.
Materials And Methods: We conducted a retrospective cohort study using the National Inpatient Sample database from 2015 to 2017.
The role of COVID-19 vaccines in the development and recurrence of pemphigus and bullous pemphigoid.
J Eur Acad Dermatol Venereol
August 2024
Article Synopsis
- - Port-wine stains (PWS) are treated with pulsed-dye laser (PDL), but their effectiveness can be limited by revascularization; sirolimus (SIRO) may help counteract this issue.
- - A systematic review of studies from 2000 to 2023 analyzed the effects of combining SIRO with PDL for PWS treatment, involving nine studies with a total of 58 patients.
- - While some studies showed improved treatment parameters with the combination therapy, inconsistencies among the studies indicate a need for more extensive research and standardized evaluation to confirm safety and effectiveness.
Article Synopsis
- Fairness products, popular in subcontinental Asia, can contain harmful ingredients that are banned in some countries, highlighting a need for awareness.* -
- A study analyzed 152 fairness cream commercials from YouTube, revealing that 84.21% targeted women, 77.63% featured celebrities, and 47.37% listed specific ingredients.* -
- The findings suggest dermatologists should educate consumers on the risks of fairness creams and promote overall skin health over mere skin lightening.*
An analysis of the pemphigus content on Facebook, Twitter, Instagram, and YouTube social media platforms.
View Article and Find Full Text PDFArticle Synopsis
- Skin cancer encompasses various types of skin tumors, with surgical excision being a standard treatment option, although other factors can influence this decision.
- Research indicates that topical treatments can reduce the necessity for surgery and its potential complications, making them increasingly relevant in dermatological practice.
- The review will explore the effectiveness and criteria for using topical therapies in treating basal cell carcinoma (BCC) and actinic keratosis (AK), while also considering the cost-effectiveness and implications of these treatments.