Gestational Hypertension: A Contemporary Review of Epidemiology, Pathophysiology, and Therapeutic Approaches.

Gestational hypertension and preeclampsia are frequently encountered conditions in pregnancy, often occurring around the time of delivery. Mild cases of these conditions in the near term typically result in few complications for both the mother and the newborn. However, women diagnosed with gestational hypertension or preeclampsia need careful monitoring of both maternal and fetal well-being throughout pregnancy, and those with severe symptoms should receive hospital- based management.

Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach 2.0.

The brain is composed of different cells, such as neurons, glia, endothelial cells, etc [...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.

The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates with extracellular vesicles (EVs) in the central nervous system of individuals with AD, which is linked to its clearance and prion-like propagation. However, the identities of the assembled tau species and EVs, as well as how they associate, are not known.

Allergic potential & molecular mechanism of skin sensitization of cinnamaldehyde under environmental UVB exposure.

Fragrance, a key ingredient in cosmetics, often triggers skin allergy causes rashes, itching, dryness, and cracked or scaly skin. Cinnamaldehyde (CA), derived from the bark of the cinnamon tree, used as a fragrance and is a moderate skin sensitizer. CA exhibits strong UVB absorption, its allergic potential and the molecular mechanisms underlying skin sensitization under UVB exposure remain largely unexplored.

Continuous Monitoring of Heart Rate Variability in Free-Living Conditions Using Wearable Sensors: Exploratory Observational Study.

Background: Wearable physiological monitoring devices are promising tools for remote monitoring and early detection of potential health changes of interest. The widespread adoption of such an approach across communities and over long periods of time will require an automated data platform for collecting, processing, and analyzing relevant health information.

Objective: In this study, we explore prospective monitoring of individual health through an automated data collection, metrics extraction, and health anomaly analysis pipeline in free-living conditions over a continuous monitoring period of several months with a focus on viral respiratory infections, such as influenza or COVID-19.

Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.

Two retinal transcription factors, cone-rod homeobox (CRX) and neural retina leucine zipper (NRL), cooperate functionally and physically to control photoreceptor development and homeostasis. Mutations in CRX and NRL cause severe retinal diseases. Despite the roles of NRL and CRX, insight into their functions at the molecular level is lacking.

Enzyme Replacement Therapy for CLN2 Disease: MRI Volumetry Shows Significantly Slower Volume Loss Compared with a Natural History Cohort.

Background And Purpose: Neuronal ceroid lipofuscinoses are a group of neurodegenerative disorders. Recently, enzyme replacement therapy (ERT) was approved for neuronal ceroid lipofuscinosis type 2 (CLN2), a subtype of neuronal ceroid lipofuscinoses. The aim of this study was to quantify brain volume loss in CLN2 disease in patients on ERT in comparison with a natural history cohort using MRI.

Chemico-nutritional characterization and anti-inflammatory potential of Chirabilva ( Roxb.) seed: alternate source of protein supplement and fatty acids.

Exploring unconventional protein sources can be an alternative strategy to meet the deficiency. The seeds of Chirabilva ( Roxb., Family- Ulmaceae) are eaten raw by the ethnic communities of Southeast Asian countries.

Tracking genetically modified (GM) rice ingredients in samples of packed rice and food products from the marketplace in India: a pilot study for regulatory compliance.

Purpose: More than 20 genetically modified (GM) food crops including rice have been approved in many countries. GM rice and derived products have not yet been approved in India so they are considered as unauthorized genetically modified organisms (GMOs) in the country. Therefore it is important to track whether the rice containing food items, available in the marketplace are GMO-free.

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathology.

Alzheimer's disease (AD) is a neurodegenerative disorder with complex pathological manifestations and is the leading cause of cognitive decline and dementia in elderly individuals. A major goal in AD research is to identify new therapeutic pathways by studying the molecular and cellular changes in the disease, either downstream or upstream of the pathological hallmarks. In this study, we present a comprehensive investigation of cellular heterogeneity from the temporal cortex region of 40 individuals, comprising healthy donors and individuals with differing tau and amyloid burden.

Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.

Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation. Here, we show the involvement of vesicular trafficking protein Rab7 in regulating the colonic mucus system.

A Review on the Effect of Metal Oxide Nanoparticles on Tribological Properties of Biolubricants.

This review provides a comprehensive and accessible literature review on the integration of nanoparticles into biolubricants to enhance wear and friction regulation, thus improving the overall lubricated system performance. Nanotechnology has significantly impacted various industries, particularly in lubrication. Nanobiolubricants offer promising avenues for enhancing tribological properties.

Study on the electronics and structural properties of transition metal-doped LaMoO.

Context: LaMoO is a potential electrolyte material for SOFC due to its higher oxygen conduction at high temperatures. However, LaMoO suffers from detrimental phase transition at high temperature from monoclinic α to cubic β phase. This phase transition can be prevented by lowering the temperature.

Distinct microglial transcriptomic signatures within the hippocampus.

Microglia, the resident immune cells of the brain, are crucial in the development of the nervous system. Recent evidence demonstrates that microglia modulate adult hippocampal neurogenesis by inhibiting cell proliferation of neural precursors and survival both in vitro and in vivo, thus maintaining a balance between cell division and cell death in the neural stem cell pool. There are increasing reports suggesting these microglia found in neurogenic niches differ from their counterparts in non-neurogenic areas.

Associations of Preconception Body Weight, Body Mass Index, and Hypertension with Preeclampsia.

Maximizing preconception health is an important strategy to prevent preeclampsia in pregnancy. Preeclampsia remains a significant cause of maternal and fetal morbidity and mortality. We examined the associations between preconception maternal body weight, body mass index (BMI), and blood pressure with preeclampsia and its related outcomes.

A double-ring of human RAD52 remodels replication forks restricting fork reversal.

Unlabelled: Human RAD52 is a multifunctional DNA repair protein involved in several cellular events that support genome stability including protection of stalled DNA replication forks from excessive degradation . In its gatekeeper role, RAD52 binds to and stabilizes stalled replication forks during replication stress protecting them from reversal by SMARCAL1 . The structural and molecular mechanism of the RAD52-mediated fork protection remains elusive.

L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats.

Background: Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects of the roots of L. ( L.