Publications by authors named "Gaur N"

Bifacial perovskite solar cells (Bi-PSCs) have attracted substantial attention within the photovoltaic (PV) community due to their potential for enhanced power generation, suitability for integration into building structures and applicability in multijunction PV systems. This study presents the fabrication of efficient Bi-PSCs and investigates their unique properties using various characterization techniques, including Lambertian reflection effects through tilt angle arrangements and bottom albedo illuminations. The control device achieved a maximum power conversion efficiency (PCE) of 17.

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Traditional full-color displays typically use a pixel layout with three side-by-side subpixels emitting red (R), green (G), and blue (B) colors. However, this configuration limits the resolution especially in augmented reality (AR) and virtual reality (VR) applications. To address the issue of low pixel density in display technology, this study demonstrated vertically stacked three-terminal (3-T) bottom-emitting tandem OLEDs (sOLED).

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  • - This study investigates corneal neurotization (CN), a new surgical method to restore healthy nerve function to the cornea affected by neurotrophic keratopathy (NK), which arises from lost corneal innervation.
  • - Existing treatments mainly focus on preventing damage to the cornea rather than treating the root cause of sensation loss, which makes CN a significant advancement in the field.
  • - The review discusses current research, including clinical studies and case reports, assessing the effectiveness of CN as a potentially permanent solution for NK, aiming to improve ocular surface health.
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  • * Current guidelines recommend early combination therapy using four drug classes, especially ARNI, which significantly reduces morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF).
  • * A national consensus by Indian cardiology experts emphasizes that ARNI should be initiated early in HFrEF patients, including those hospitalized, and can also benefit patients with preserved and mildly reduced ejection fractions.
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In the present work, the synthesis of BaZrO nano-ceramics is explored through flash combustion utilizing glycine as a fuel. The resulting nanoparticles exhibit a cubic 3̄ space group and a spherical morphology with an average size of 45.31 nm.

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To assess the functional relevance of a putative Major Facilitator Superfamily protein (PF3D7_0210300; 'MFSDT') as a drug transporter, using for orthologous protein expression. Complementary Determining Sequence encoding MFSDT was integrated into the genome of genetically engineered strain MSY8 via homologous recombination, followed by assessing its functional relevance as a drug transporter. The modified strain exhibited plasma membrane localization of MFSDT and characteristics of an Major Facilitator Superfamily transporter, conferring resistance to antifungals, ketoconazole and itraconazole.

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Epoxide hydrolases (EHs) are a group of ubiquitous enzymes that catalyze hydrolysis of chemically reactive epoxides to yield corresponding dihydrodiols. Despite extensive studies on EHs from different clades, generic rules governing their substrate specificity determinants have remained elusive. Here, we present structural, biochemical and molecular dynamics simulation studies on MiEH2, a plant epoxide hydrolase from Mangifera indica.

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Wireless sensor networks (WSN) are among the most prominent current technologies. Its popularity has skyrocketed because of its capacity to operate in difficult situations. The WSN market encompasses various industries, including building automation, security networks, healthcare systems, logistics, and military operations.

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For a safe sclerotherapy session to be completed in the orbital low-flow malformation (namely lymphovenous malformation or venolymphatic malformation), accurate identification of the target lesion for the drug injection is crucial. Regarding the dependability and viability of the injection approach, the authors have discussed their experiences with image-guided percutaneous sclerotherapy on a few patients.

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Background: Researchers are focusing their emphasis on quick and real-time healthcare and monitoring systems because of the contemporary modern world's rapid technological improvements. One of the best options is smart healthcare, which uses a variety of on-body and off-body sensors and gadgets to monitor patients' health and exchange data with hospitals and healthcare professionals in real time. Utilizing the primary user (PU) spectrum, cognitive radio (CR) can be highly useful for efficient and intelligent healthcare systems to send and receive patient health data.

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Chronic kidney disease (CKD) is a major contributor to morbidity and mortality in India. CKD often coexists with heart failure (HF), diabetes, and hypertension. All these comorbidities are risk factors for renal impairment.

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Light emission from organoboron compounds of Schiff bases is found to depend strongly on their chemical structure. Two of these compounds (OB1 and OB2), which contain a benzene ring between the Schiff base moieties, exhibit weak fluorescence in methanol, with marked viscosity dependence. Fluorescence lifetimes of these compounds are in picosecond timescale, as determined by femtosecond optical gating (FOG).

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  • * Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are new medications that not only help control blood sugar in T2DM but also provide significant cardiovascular benefits for HF patients.
  • * Evidence shows that SGLT2i can enhance heart function and improve outcomes in HF whether patients have diabetes or not, making them valuable for a wide range of HF patients, especially in India.
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  • - In India, heart failure (HF) is a significant health issue, impacting younger individuals compared to Western countries, but many patients do not receive proper medical treatment.
  • - Selective β-1 blockers, like bisoprolol, are important in treating HF because they help lower heart rate and reverse negative heart and blood vessel changes associated with the condition.
  • - Despite the benefits of bisoprolol for various HF cases and comorbid conditions, its use in India remains suboptimal, prompting a consensus on its effectiveness and recommending it for better patient care.
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A number of small molecule and protein therapeutic candidates have been developed in the last four years against SARS-CoV-2 spike. However, there are hardly a few molecules that have advanced through the subsequent discovery steps to eventually work as a therapeutic agent. This is majorly because of the hurdles in determining the affinity of potential therapeutics with live SARS-CoV-2 virus.

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Smart hospitals are poised to greatly enhance life quality by offering persistent health monitoring capabilities. Remote healthcare and surgery, which are highly dependent on low latency, have seen a transformative improvement with the advent of 5G technology. This has facilitated a new breed of healthcare services, including monitoring and remote surgical procedures.

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In this study, we explored the sphingolipid (SL) landscape in Candida auris, which plays pivotal roles in fungal biology and drug susceptibility. The composition of SLs exhibited substantial variations at both the SL class and molecular species levels among clade isolates. Utilizing principal component analysis, we successfully differentiated the five clades based on their SL class composition.

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Crystallizing galactocele is an uncommon condition that produces a viscous, chalky substance on fine needle aspiration cytology. (FNAC). Both the diagnosis and the management of this illness include the use of FNAC.

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The deep learning method (DLM) is one way to fix issues in optical nonorthogonal multiple access (O-NOMA) systems that are caused by signals that overlap and interfere with each other. NOMA increases the optical framework's spectrum efficiency, allowing several users to share the same time-frequency resources. However, NOMA-DLM-based detection's complicated interference patterns and variable channel conditions are challenging for conventional detection methods to manage.

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The world of medicine demands from the research community solutions to the emerging problem of SARS-CoV-2 variants and other such potential global pandemics. With advantages of specificity over small molecule drugs and designability over antibodies, miniprotein therapeutics offers a unique solution to the threats of rapidly emerging SARS-CoV-2 variants. Unfortunately, most of the promising miniprotein binders are designed and it is not viable to generate molecules for each new variant.

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Background: To evaluate the clinical profile, outcomes and antibiotic resistance in bacterial endophthalmitis.

Methods: This was a post-hoc analysis of a study conducted at a tertiary centre, where 60 consecutive cases of culture-proven bacterial endophthalmitis were included prospectively. Group 1 included coagulase-negative Staphylococcus endophthalmitis (CNSE), while group 2 included the remaining cases.

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Phloem-feeding insects include many important agricultural pests that cause crop damage globally, either through feeding-related damage or upon transmission of viruses and microbes that cause plant diseases. With genetic crop resistances being limited to most of these pests, control relies on insecticides, which are costly and damaging to the environment and to which insects can develop resistance. Like other plant parasites, phloem-feeding insects deliver effectors inside their host plants to promote susceptibility, most likely by a combination of suppressing immunity and promoting nutrient availability.

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Aim: Wolfram Syndrome (WS) is a rare condition caused by mutations in , with a poor prognosis and no cure. Mono-agonists targeting the incretin glucagon-like-peptide 1 (GLP-1) have demonstrated disease-modifying potential in pre-clinical and clinical settings. Dual agonists that target GLP-1 and glucose-dependent insulinotropic polypeptide (GIP-1) are reportedly more efficacious; hence, we evaluated the therapeutic potential of dual incretin agonism in a loss-of-function rat model of WS.

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Background: Xylitol has a wide range of applications in the pharmaceuticals, cosmetic, food and beverage industry. Microbial xylitol production reduces the risk of contamination and is considered as environment friendly and sustainable compared to the chemical method. In this study, random mutagenesis and genetic engineering approaches were employed to develop Candida tropicalis strains with reduced xylitol dehydrogenase (XDH) activity to eliminate co-substrate requirement for corn cob-based xylitol-ethanol biorefinery.

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