Clinical Profile, Yield of Cartridge-based Nucleic Acid Amplification Test (GeneXpert), and Outcome in Children with Tubercular Meningitis.

Background: GeneXpert MTB/RIF is a test for early, rapid diagnosis of tubercular meningitis (TBM).

Aim: The aim of this article was to study the clinical profile, radiological features, yield of GeneXpert, neurosurgical interventions, and outcome of TBM in children.

Settings And Design: This was a retrospective and prospective observational study.

Association of blood pressure and BMI to corrected QT interval in young adults.

Hypertension is often associated with obesity. Uncontrolled hypertension can lead to uncorrected cardiac dysautonomia that makes cardiac repolarization abnormally prolonged. Modern dietary habits, stress, and bad lifestyle habits make young adults vulnerable to hazards of health.

Inorganic polyphosphate in platelet rich plasma accelerates re-epithelialization and .

Wound healing requires well-coordinated events including hemostasis, inflammation, proliferation, and remodeling. Delays in any of these stages leads to chronic wounds, infections, and hypertrophic scarring. Burn wounds are particularly problematic, and may require intervention to ensure timely progression to reduce morbidity and mortality.

Rapid Start of Antiretroviral Therapy in Youth Diagnosed with HIV Infection.

Background: Guidelines for the use of antiretroviral agents in adults and adolescents with HIV recommend that antiretroviral therapy (ART) be started as soon as possible. While rapid initiation of ART in adults with HIV has been well-described, there is relatively little information describing this approach for youth.

Methods: On April 1, 2018, St.

Strong Interactions between the Nanointerfaces of Silica-Supported MoC/MoP Heterojunction Promote Hydrogen Evolution Reaction.

Hydrogen is one of the cleanest forms of energy carrier which can solve the twin problem of exhaustion of fossil fuels and climate change. The exploration of low-cost and earth-abundant electrocatalysts for hydrogen generation process is an emerging area of research. Profound catalyst tailoring with mutually contrast phases on a porous support for crafting large hydrogen evolution reaction (HER) active sites increases the catalytic activity in many folds.

Impact of incarceration on nutritional status and oral health among male inmates of central jail of Jaipur city, India.

Aim: Prison is an especially difficult environment for promoting oral health and leads to the exacerbation of unhealthy behaviors. This study set out to assess the impact of incarceration on nutritional status and oral health among the male prison inmates of Central Jail of Jaipur city, Rajasthan, India.

Material And Method: A cross sectional study was conducted among 181 male inmates.

Soil quality parameters vis-a-vis growth and yield attributes of sugarcane as influenced by integration of microbial consortium with NPK fertilizers.

Intensive agriculture involving high crop intensity, unavailability of organics, and higher use of straight fertilizers causes imbalanced use and deficiencies of several other macro and micronutrients. Nutrients supply through the integration of microbial consortium containing Gluconacetobater diazotrophicus, Trichoderma harzianum, and Pseudomonas fluorescens can reduce the requirements on the one hand and can also increase the response of chemical fertilizers. Thus we had planned the present experiment with the objectives (i) to determine the effect of integrated application of microbial consortium (MC) and NPK fertilizer on soil quality parameters and crop growth and yield attributes and (ii) to assess the effect of integration on agronomic efficiency of N, P and K and find out the possibilities for reduction in applied doses of NPK, if any.

Tuning of Bistability, Thermal Stability of the Metastable States, and Application Prospects in the C -Symmetric Designs of Multiple Azo(hetero)arenes Systems.

Light-responsive molecular systems with multiple photoswitches in C -symmetric designs have enormous application potential. The design part of such molecular systems is critical due to its influence in several properties associated with the photoswitches. In order to tune, and in the evaluation of the design-property relationship, we synthesized 18 tripodal systems with variations in the core, linkers, connectivity, and azo(hetero)arene photoswitches.

Teleassistance and teleconsultation using smartphones and its contribution in clinical progress of oral and maxillofacial surgery.

Smartphones, an advanced mobile device having combined function of a computer and cellular phone, have become an effective communication within and between specialties for management of patients. It provides voice, text, multimedia messages, camera, and E-mail option and helps the surgical team to communicate with each other. The application of computer technology in the field of cranio and maxillofacial surgery opened a new perspective in the preoperative planning and accurate intraoperative realization of treatment concept.

Air quality assessment among populous sites of major metropolitan cities in India during COVID-19 pandemic confinement.

The present study aims to determine the impact of COVID-19 pandemic confinement on air quality among populous sites of four major metropolitan cities in India (Delhi, Mumbai, Kolkata, and Chennai) from January 1, 2020 to May 31, 2020 by analyzing particulate matter (PM2.5 and PM10), nitrogen dioxide (NO), ammonia (NH), sulfur dioxide (SO), carbon monoxide (CO), and ozone levels. The most prominent pollutant concerning air quality index (AQI) was determined by Pearson's correlation analysis and unpaired Welch's two-sample t test was carried out to measure the statistically significant reduction in average AQI for all the four sites.

Using a Modeling-Based Approach to Assess and Optimize HIV Linkage to Care Services.

Evidence-based linkage to care interventions (LTCs) help recently diagnosed HIV+ individuals engage in care in a timely manner yet are heavily impacted by the systems in which they are embedded. We developed a prototype agent-based model informed by data from an established LTC program targeting youth and young adults aged 13-24 in Memphis, Tennessee. We then tested two interventions to improve LTC in a simulated environment: expanding testing sites versus using current testing sites but improving direct referral to LTC staff from organizations providing testing, to understand the impact on timely linkage to care.

Insights into the Stabilization of Fluoride Ions in Ionic Liquids: Pointers to Better Fluorinating Agents.

The fluorination efficiency of a fluorinating agent depends on the free availability of the fluoride ions, which in turn depends on its interaction with its solvation shell. A stable fluoride-based poor solvate ionic liquid (SIL) comprising 1-ethyl-3-methylimidazolium (EMIM) cation and ethylene glycol (EG) was recently reported and demonstrated as a fluorinating agent. Herein, we performed calculations and molecular dynamics simulations to gain a microscopic understanding of the intermolecular interactions in this SIL in gas, liquid, and crystalline phases.

Early experience with pediatric cardiac transplantation in a limited resource setting.

Background: Pediatric heart transplantation is a now a well-established and standard treatment option for end stage heart failure for various conditions in children. Due to logistic issues, it is not an option for in most pediatric cardiac centres in the third world.

Aim: We sought to describe our early experience in the current era in India.

Health-related quality of life in premenopausal women with hormone-receptor-positive, HER2-negative advanced breast cancer treated with ribociclib plus endocrine therapy: results from a phase III randomized clinical trial (MONALEESA-7).

Background: This analysis evaluated patient-reported outcomes (PROs) to assess health-related quality of life (HRQoL) in the phase III MONALEESA-7 trial, which previously demonstrated improvements in progression-free survival (PFS) and overall survival (OS) with ribociclib (cyclin-dependent kinase 4/6 inhibitor) + endocrine therapy (ET) compared with placebo + ET in pre- and perimenopausal patients with hormone-receptor-positive, HER2-negative (HR+/HER2-) advanced breast cancer (ABC).

Methods: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life questionnaire C30 (QLQ-C30) and the EQ-5D-5L were used to evaluate HRQoL.

Results: EORTC QLQ-C30 assessments were evaluable for 335 patients in the ribociclib arm and 337 patients in the placebo arm.

Clinico-radiological Presentation of COVID-19 Patients at a Tertiary Care Center at Bhilwara Rajasthan, India.

Background: COVID-19 has now become a pandemic. From Wuhan, China, in December 2019 to European countries, USA and now it seems to gain a strong foothold in India. The objective of this work is to report the initial experience with demographic and clinical features, and management of COVID-19 patients admitted in medical college Bhilwara, India.

Colossal Dielectric Responses from the Wide Band Gap 2D-Semiconducting Amine Templated Hybrid Framework Materials.

Two unprecedented organic amine templated silver organophosphonate hybrid solids have been synthesized hydrothermally by varying the molar ratio of the reactants. Both of the compounds consist of novel tetra- and penta-nuclear silver phosphonate basic building units. The dielectric constants are extremely large due to the charge separation of anionic metal phosphonate frameworks and cationic templated piperazine moieties in the compounds, as found for the first time in a hybrid organophosphate family.

Fabrication of a SnO-Based Hydroelectric Cell for Green Energy Production.

The generation of electricity by dissociating water into HO and OH ions through a hydroelectric cell (HEC) without liberating any toxic waste has achieved a groundbreaking feat. Nanoporous magnesium-doped SnO and cobalt-doped SnO materials have been prepared via a novel sol-gel method. The X-ray diffraction patterns of Mg-doped SnO and Co-doped SnO completely match with those of pure SnO, which confirms the interstitial substitution of Mg and Co in the pristine SnO.

Structural dynamics of an iron molybdate catalyst under redox cycling conditions studied with in situ multi edge XAS and XRD.

The structural dynamics and phase transformations of an iron molybdate catalyst with excess molybdenum trioxide (Mo/Fe = 2.0) were studied during redox cycling of the catalyst using in situ multi-edge X-ray absorption spectroscopy (XAS) at the Mo K-edge (transmission mode) and Fe K-edge (fluorescence mode) in combination with X-ray diffraction (XRD). X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) analysis showed that heating under reducing conditions with methanol up to 400 °C produced MoO and FeMoO.

Mycoremediation affects antioxidative status in winter rye plants grown at Chernobyl exclusion zone site in Ukraine.

Soil contaminated with heavy metals in general and radionuclides in particular represents an escalating problem for all living organisms. Since, Chernobyl nuclear power plant accident in 1986 in Ukraine, an exclusion zone of 30 km around the former power plant is uninhabitable land due to severe contamination. Two most notable beta emitters contributing to dose hazards for decades is radioactive Cs/Sr.

Mucosal barrier injury-associated bloodstream infections in pediatric oncology patients.

Background: Single-center reports of central line-associated bloodstream infection (CLABSI) and the subcategory of mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) in pediatric hematology oncology transplant (PHO) patients have focused on the inpatient setting. Characterization of MBI-LCBI across PHO centers and management settings (inpatient and ambulatory) is urgently needed to inform surveillance and prevention strategies.

Methods: Prospectively collected data from August 1, 2013, to December 31, 2015, on CLABSI (including MBI-LCBI) from a US PHO multicenter quality improvement network database was analyzed.

Facile Synthesis of SiO₂/CMC/Ag Hybrids Derived from Waste Biomass (Sugarcane Bagasse) Having Special Medical Application.

This research is focused on the use of sol gel technique to synthesize amorphous SiO₂ hybrids derived from lab made CMC (made from sugarcane bagasse) and tetraethoxysilane (TEOS) comprising silver nanoparticles (Ag-NPs). The dominant absorption peak in the order of 425 nm confirms the presence of Ag-NPs hybrid group owing to the surface Plasmon resonance (SPR). Ag-NPs hybrid characterization of was performed by Ultra violet-visible spectra (UV-Vis), Scanning electronic microscopy (SEM), Transmission electron microscopy (TEM), Particle size analyser (PSA), Energy Dispersive X-ray spectroscopy (EDX), X-ray diffractometer (XRD) and Fourier transform infrared spectroscopy (FTIR).

Comparative Evaluation of Hypotensive and Normotensive Anesthesia on LeFort I Osteotomies: A Randomized, Double-Blind, Prospective Clinical Study.

Introduction: Orthognathic surgery can account for a considerable amount of blood loss since the vascularization of maxillofacial region is such that major bleeding can occur. Intra-bony bleed is often involved as a major aspect of blood loss associated with osteotomies, especially LeFort I osteotomy when performed during orthognathic surgery. This study evolved as a result of the increasing concern to attain a clear surgical field and reduce the duration of surgical procedure and the amount of blood loss associated with orthognathic surgery with the use of controlled hypotension.

Liver Enzyme Elevations in Volunteer Infection Studies: Findings and Recommendations.

Malaria volunteer infection studies (VISs) accelerate new drug and vaccine development. In the induced blood-stage malaria (IBSM) model, volunteers are inoculated with erythrocytes infected with . Observations of elevated liver enzymes in the IBSM model with new chemical entities (NCEs) promoted an analysis of available data.

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial.

Background: (+)-SJ000557733 (SJ733) is a novel, orally bioavailable inhibitor of Plasmodium falciparum ATP4. In this first-in-human and induced blood-stage malaria phase 1a/b trial, we investigated the safety, tolerability, pharmacokinetics, and antimalarial activity of SJ733 in humans.

Methods: The phase 1a was a single-centre, dose-escalation, first-in-human study of SJ733 allowing modifications to dose increments and dose-cohort size on the basis of safety and pharmacokinetic results.

Psychological risk factors associated with internet and smartphone addiction among students of an Indian dental institute.

Background: The internet and smartphones have a strong potential for addiction. Excessive use of these technologies can have adverse effects on psychological well-being of the users.

Objectives: The objective of the study is to find out the effects of internet addiction (IA) and smartphone addiction (SA) on psychological outcomes of dental students in an Indian institute.