Harnessing Blockchain to Transform Healthcare Data Management: A Comprehensive Research Agenda.

Properly managing healthcare data is a complex endeavor that must balance the requirements and interests of many stakeholders. In this paper, we present the findings from a panel discussion with healthcare professionals and academics, who elaborate on the current situation in healthcare data management as well as the future role that blockchain could play in this sector. Based on the findings of this panel, we structure the research field of healthcare data management and provide numerous avenues for future research.

Full Familiarisation Is Not Required for the Self-Paced 1 km Treadmill Walk to Predict Peak Oxygen Uptake in Phase IV Cardiac Patients.

Exercise is a recommended part of phase IV cardiovascular rehabilitation (CR). The 1 km treadmill walk test (1-KTWT) is a submaximal continuous exercise test to predict cardiorespiratory fitness in patients with cardiovascular disease. We examined physiological, metabolic and subjective responses in patients with cardiovascular disease with self-selected, unchanging walking speed for two 1-KTWTs.

An Inflamed and Infected Reconstructed Human Epidermis to Study Atopic Dermatitis and Skin Care Ingredients.

Atopic dermatitis (AD), the most common inflammatory skin disorder, is a multifactorial disease characterized by a genetic predisposition, epidermal barrier disruption, a strong T helper (Th) type 2 immune reaction to environmental antigens and an altered cutaneous microbiome. Microbial dysbiosis characterized by the prevalence of () has been shown to exacerbate AD. In recent years, in vitro models of AD have been developed, but none of them reproduce all of the pathophysiological features.

Challenging Cosmetic Innovation: The Skin Microbiota and Probiotics Protect the Skin from UV-Induced Damage.

Many studies performed in the last decade have focused on the cutaneous microbiota. It has been shown that this microbiota plays a key role in skin homeostasis. Considered as "a second barrier" to the environment, it is very important to know how it reacts to exogenous aggressions.

Caffeine-Containing Energy Shots Cause Acute Impaired Glucoregulation in Adolescents.

Caffeine-containing, nutritionally fortified energy shots are consumed at high rates by adolescents, yet little is known about their metabolic impact. The purpose of this study was to examine the consequences of small format, caffeinated energy shots on glucose metabolism and gastrointestinal hormone secretion in adolescents. Twenty participants aged 13-19 years participated in a double-blind, randomized cross-over study consisting of two trials separated by 1-4 weeks.

Intravascular catheter migration: A cross-sectional and health-economic comparison of adhesive and subcutaneous engineered stabilisation devices for intravascular device securement.

The Infusional Services Team at a large cancer centre in Belfast, Northern Ireland, performed a cross-sectional analysis of two catheter securement technologies to address an area of frequent, but underestimated concern - peripherally inserted central catheter migration and dislodgement. Healthcare practitioner and patient feedback, along with economic impact, were assessed. The costs associated with catheter replacement during the adhesive device group study period were calculated using an average cost per insertion, based on material costs required for the procedure.

The metabolic equivalents of one-mile walking by older adults; implications for health promotion.

Instructions for older adults regarding the intensity of walking may not elicit an intensity to infer health gains. We recorded the metabolic equivalents (METs) during a 1-mile walk using constant and predicted values of resting MET in older adults to establish walking guidelines for health promotion and participation. In a cross-sectional design study, participants (15 men, 10 women) walked 1-mile overground, in a wooden floored gymnasium, wearing the Cosmed K4b for measurement of energy expenditure.

Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction.

Blackcurrant is rich in anthocyanins that may affect exercise-induced physiological responses. We examined tissue oxygen saturation, muscle activity, cardiovascular responses and femoral artery diameter during a submaximal sustained isometric contraction. In a randomised, double-blind, crossover design, healthy men ( = 13, age: 25 ± 4 years, BMI: 25 ± 3 kg·m, mean ± SD) ingested New Zealand blackcurrant (NZBC) extract (600 mg∙day CurraNZ™) or placebo (PL) for 7-days separated by 14-days washout.

Dose effects of New Zealand blackcurrant on substrate oxidation and physiological responses during prolonged cycling.

Purpose: It has been previously shown that New Zealand blackcurrant (NZBC) extract increased fat oxidation during short duration cycling. The present study examined the effect of different doses of NZBC extract on substrate oxidation and physiological responses during prolonged cycling.

Methods: Using a randomized counterbalanced Latin-square design, 15 endurance-trained male cyclists (age: 38 ± 12 years, height: 187 ± 5 cm, body mass: 76 ± 10 kg, [Formula: see text]: 56 ± 8 mL kg min, and mean ± SD) completed four separate 120-min cycling bouts at 65% [Formula: see text] after ingesting no dose, or one of three doses (300, 600, or 900 mg day) of NZBC extract (CurraNZ™) for 7 days.

Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Purpose: Blackcurrant contains anthocyanins that could alter cardiovascular function and reduce cardiovascular disease risk. We examined dose responses of New Zealand blackcurrant (NZBC) extract on cardiovascular function during supine rest.

Methods: Fifteen endurance-trained male cyclists (age: 38 ± 12 years, height: 178 ± 5 cm, body mass: 76 ± 10 kg, [Formula: see text]: 56 ± 8 mL kg min, mean ± SD) were randomly assigned using a counterbalanced Latin square design to complete four conditions, a control of no NZBC, or one of three doses (300, 600 or 900 mg day) of NZBC extract (CurraNZ™) for 7-days with a 14-day washout.

Data set for transcriptome analysis of Escherichia coli exposed to nickel.

Ni is recognized as an element that is toxic to humans, acting as an allergen and a carcinogenic agent, and it is also toxic to plants. The toxicity of Ni has been understudied in microorganisms. The data presented here were obtained by submitting the model bacterium Escherichia coli K-12 to nickel stress.

Ni exposure impacts the pool of free Fe and modifies DNA supercoiling via metal-induced oxidative stress in Escherichia coli K-12.

The biology of nickel has been widely studied in mammals because of its carcinogenic properties, whereas few studies have been performed in microorganisms. In the present work, changes accompanying stress caused by nickel were evaluated at the cellular level using RNA-Seq in Escherichia coli K-12. Interestingly, a very large number of genes were found to be deregulated by Ni stress.

Beneficial Physiological Effects With Blackcurrant Intake in Endurance Athletes.

Blackcurrant contains anthocyanins, known to influence vasorelaxation and peripheral blood flow. We examined the effects of 7 days intake of Sujon New Zealand blackcurrant powder (6g/day) on the lactate curve, maximum oxygen uptake, and cardiovascular responses at rest and during cycling. Thirteen trained triathletes with >3 yrs experience (8 men, age: 38 ± 8 yrs, body mass: 71 ± 9 kg, BF%: 19 ± 5%, mean ± SD) performed two incremental cycling protocols with recording of physiological and cardiovascular responses (Portapres Model 2).

Cu binding by the Escherichia coli metal-efflux accessory protein RcnB.

Divalent cations play fundamental roles in biological systems where they act as structural and reactive determinants. Their high reactivity with biomolecules has forced living cells to evolve specific pathways for their in vivo handling. For instance the excess of metal can be expelled by dedicated efflux systems.

Aging, functional capacity and eccentric exercise training.

Aging is a multi-factorial process that ultimately induces a decline in our physiological functioning, causing a decreased health-span, quality of life and independence for older adults. Exercise participation is seen as a way to reduce the impact of aging through maintenance of physiological parameters. Eccentric exercise is a model that can be employed with older adults, due to the muscle's ability to combine high muscle force production with a low energy cost.

Isometric strength and steadiness adaptations of the knee extensor muscles to level and downhill treadmill walking in older adults.

An ageing related decline in muscle strength and steadiness decreases quality of life and increases the risk for falls. Downhill treadmill walking (DTW) may enhance muscle strength and steadiness in older adults. Eighteen healthy older adults (age: 67 ± 4, body mass: 75 ± 14 kg) completed 12-weeks of level treadmill walking (LTW, 0 %, n = 8) or DTW (-10 %, n = 10) (30 min, 3 days per week) at a self-selected walking speed (re-adjusted in week 4 and 8).

Pseudomonas putida KT2440 response to nickel or cobalt induced stress by quantitative proteomics.

Nickel and cobalt are obligate nutrients for the gammaproteobacteria but when present at high concentrations they display toxic effects. These two metals are present in the environment, their origin being either from natural sources or from industrial use. In this study, the effect of inhibitory concentrations of Ni or Co was assessed on the soil bacterium Pseudomonas putida KT2440 using a proteomic approach.

Cardiovascular responses during downhill treadmill walking at self-selected intensity in older adults.

Cardiovascular responses of older adults to downhill (DTW, -10% incline) and level treadmill walking (0%) at self-selected walking speed (SSWS) were examined. Fifteen participants (age 68 ± 4 yr, height 1.69 ± 0.

Functional mobility of older adults after concentric and eccentric endurance exercise.

Age-associated decline in muscle mass and strength impairs functional mobility in older adults. We examined the effects of an eccentric endurance exercise programme (downhill treadmill walking, DTW) at a self-selected walking speed (SSWS) on functional mobility and eccentric and concentric strength of m. quadriceps femoris of older adults.

Carboxymethyl-beta-cyclodextrin mitigates toxicity of cadmium, cobalt, and copper during naphthalene biodegradation.

Hazardous waste sites are commonly contaminated with both organic and metal pollutants. Many metal pollutants have been shown to inhibit organic pollutant biodegradation. We investigated the ability of a modified, polydentate cyclodextrin (carboxymethyl-beta-cyclodextrin, CMCD) to reduce the toxicity of 33.

Do Moral Communities Play a Role in Criminal Sentencing? Evidence From Pennsylvania.

Religion and social control have been a sociological concern since Durkheim and Weber, and the relationship between religion and punishment has long been the subject of speculation. However, surprisingly little empirical research exists on the role of religion or religious context in criminal justice, and almost no research on the role of religious context on actual sentencing practices. We conceptualize the potential relationships between religious context and sentencing severity by drawing from the focal concerns and court community perspectives in the sentencing literature and theory developed by Rodney Stark.

[A long-term follow-up quality evaluation of patients taking oral anticoagulant therapy].

Objectives: the aim of this study was to estimate the population under Vitamin-K antagonists (VKA) in the region of Limousin (France), and to assess the treatment quality and the level of knowledge of the patients.

Methods: a transversal study permitted to identify all the patients under VKA under the French general health care coverage. During 6 months, a cohort of 370 patients had been followed.