Publications by authors named "Gaukhar Baidildinova"
The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The "coagulome" as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, and kidney.
View Article and Find Full Text PDFIntroduction: There is evidence that plasma protein profiles differ in the two subtypes of pulmonary embolism (PE), isolated PE (iPE) and deep vein thrombosis (DVT)-associated PE (DVT-PE), in the acute phase. The aim of this study was to determine specific plasma signatures for proteins related to platelets in acute iPE and DVT-PE compared to isolated DVT (iDVT).
Methods: Within the Genotyping and Molecular Phenotyping of Venous ThromboEmbolism (GMP-VTE) Project, a multicenter prospective cohort study of 693 confirmed VTE cases, a highly sensitive targeted proteomics approach based on dual-antibody proximity extension assay was applied.
Platelets are the main players in thrombotic diseases, where activated platelets not only mediate thrombus formation but also are involved in multiple interactions with vascular cells, inflammatory components, and the coagulation system. Although reactivity of platelets provides information on the function of circulating platelets, it is not a full reflection of the activation state, which may be relevant for thrombotic risk assessment in various disease conditions. Therefore, studying release markers of activated platelets in plasma is of interest.
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- The study investigates Alzheimer’s disease progression in transgenic mice (TASTPM), focusing on the role of amyloidβ and microglial activity before plaque formation.
- Findings reveal that microglial numbers increase and change characteristics before plaques appear, along with altered synaptic transmission that initially enhances long-term potentiation but later declines with plaque development.
- Despite significant plaque loads, the mice experience little cognitive impairment, suggesting that the early synaptic and microglial changes might not directly lead to cognitive deficits, mirroring potential pre-diagnostic behaviors in humans.