Rehabilitation Management of a Pediatric Patient with Modified Van Nes Prosthesis after Type B-IIIA Hip Rotationplasty: A Case Report.

Van Nes rotationplasty has gained popularity as a surgical treatment for malignant bone tumors without resorting to amputation. However, the nature of the surgery poses unique challenges in the rehabilitation management in order to optimize safety and functional mobility. We describe a case of a 6-year-old female with Ewing's sarcoma of the right femur who underwent Van Nes Type B-IIIA rotationplasty.

Surgical transversus abdominis plane block with liposomal bupivacaine at cesarean: a pilot randomized trial.

Background: Postcesarean pain control is challenging. In addition to intrathecal morphine, recent studies have shown that liposomal bupivacaine administered via conventional transversus abdominis plane block reduces postcesarean opioid use. However, whether the administration of liposomal bupivacaine via a surgical approach also reduces opioid use is unknown.

Calling All Mares: Community, Identity, and Group Sex at the San Francisco Horse Market.

In this paper, masculinity and sexuality are explored from the perspective of gay men who participate in group-based sexual practices. The work contributes to the limited wider academic inquiry into collective sex environments. This is accomplished through a content analysis of 15 publicly accessible testimonials of men who have attended a group sex event called a "Horse Market" in the USA.

Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas.

In leiomyosarcoma (LMS), a very aggressive disease, a relatively transcriptionally uniform subgroup of well-differentiated tumors has been described and is associated with poor survival. The question raised how differentiation and tumor progression, two apparently antagonist processes, coexist and allow tumor malignancy. We first identified the most transcriptionally homogeneous LMS subgroup in three independent cohorts, which we named 'hLMS'.

Premature adrenarche in Prader-Willi syndrome is associated with accelerated pre-pubertal growth and advanced bone age.

Objectives: Prader-Willi syndrome (PWS) is characterized by obesity, growth hormone deficiency, hypogonadism, and a high prevalence of premature adrenarche despite reported hypothalamic-pituitary-adrenal axis dysfunction. While idiopathic premature adrenarche is associated with accelerated pre-pubertal growth and advanced bone age, the consequences of elevated adrenal androgens on growth and bone maturation in PWS remain unknown. This study therefore sought to describe age-related changes in dehydroepiandrosterone sulfate (DHEAS) and their effects on growth and bone maturation in PWS.

Modeling the competitive sorption and transport of Ni(II) and Zn(II) in soils: Comparing two multicomponent approaches.

The mobility of contaminants in soil is controlled by sorption reactions which can be affected by the presence of other solutes that compete for sorption sites. The ability to model such effects is necessary for evaluating the environmental risk of a given contaminant. In this study, the competitive sorption and transport of nickel (Ni) and zinc (Zn) in Olivier and Windsor soils was investigated using batch equilibration and miscible displacement experiments.

Modeling the sorption of Ni(II) and Zn(II) by Mn oxide-coated sand: Equilibrium and kinetic approaches.

The behavior of metal cations in oxide-dominated systems is controlled by sorption reactions, which in turn depend on pH. Descriptions of such reactions are of interest for contaminant monitoring or remediation efforts; however, widely used isotherms such as Freundlich or Langmuir neglect the effect of pH and are therefore limited in their applicability. Two pH-dependent isotherms and their kinetic analogs were developed and evaluated regarding their ability to describe equilibrium and time-dependent sorption of Ni and Zn by Mn oxide-coated sand (MOCS).

The clinician-administered PTSD Scale for DSM-5 (CAPS-5) structured interview for PTSD: A French language validation study.

The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) is a structured interview that assesses the frequency and severity of each symptom of posttraumatic stress disorder (PTSD) in relation to a single traumatic stressor over a 1-month period, allowing the trained interviewer to infer a current or lifetime diagnosis congruent with the 5th Edition of the Diagnostic and Statistical Manual of the American Psychiatric Association. This study evaluated the psychometric properties of the original English language CAPS-5 translated to French. Participants ( = 168) were recruited in clinical settings of France, Lebanon, and Canada.

Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome.

Genomic instability (GI) influences treatment efficacy and resistance, and an accurate measure of it is lacking. Current measures of GI are based on counts of specific structural variation (SV) and mutational signatures. Here, we present a holistic approach to measuring GI based on the quantification of the steady-state equilibrium between DNA damage and repair as assessed by the residual breakpoints (BP) remaining after repair, irrespective of SV type.

ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas.

Whole genome and transcriptome sequencing of a cohort of 67 leiomyosarcomas has been revealed to be one of the most frequently mutated genes in leiomyosarcomas after and . While its function is well described in the alternative lengthening of telomeres mechanism, we wondered whether its alteration could have complementary effects on sarcoma oncogenesis. alteration is associated with the down-expression of genes linked to differentiation in leiomyosarcomas, and to immunity in an additional cohort of 60 poorly differentiated pleomorphic sarcomas.

Confirmation and Expansion of the Phenotype Associated with the Recurrent p.Val837Met Variant in TRPM3.

Dyment et al. (2019) recently reported eight novel patients with intellectual disability and epilepsy associated with heterozygous de novo missense variants in TRPM3. We report a novel patient with the same recurrent de novo missense of TRPM3 found in seven of these eight cases, p.

Remediation of crude oil-contaminated coastal marsh soil: Integrated effect of biochar, rhamnolipid biosurfactant and nitrogen application.

Decontamination of oil spills from coastal wetland soils requires a delicate approach. A microcosm study was carried out to investigate the impact of integrated application of biochar, rhamnolipid (RL) biosurfactant and nitrogen (N) on petroleum hydrocarbon remediation in a Louisiana coastal saline marsh and their impact on soil microbial community. The soil was artificially contaminated with crude oil and subjected to treatments of different combinations of sugarcane residue biochar, RL, and coated urea.

Potential use of biochar and rhamnolipid biosurfactant for remediation of crude oil-contaminated coastal wetland soil: Ecotoxicity assessment.

Remediation of wetland soils contaminated with petroleum hydrocarbons is a challenging task. Biosurfactant and biochar have been used in oil remediation. However, little is known about the ecotoxicity of these materials when applied in wetland ecosystems.

Evaluation of growth and motility in non-photosynthetic Azospirillum brasilense exposed to red, blue, and white light.

Azospirillum brasilense is a non-photosynthetic rhizobacterium that promotes the growth of plants. In this work, we evaluated the effects of different light qualities on the growth, viability, and motility in combination to other culture conditions such as temperature or composition of the culture medium. Exponential cultures of A.

Exploring anaerobic CO production response to elevated nitrate levels in Gulf of Mexico coastal wetlands: Phenomena and relationships.

Recent studies have shown the effect of nitrate (NO) on carbon gas emissions from wetland soils that contradict thermodynamic predictions. In this study, CO production in three Mississippi River deltaic plain wetland soils (forest swamp, freshwater and saline marshes) with the presence of different NO levels (0.2, 2.

Sorption and Desorption Characteristics of Tylosin in Three Louisiana Soils.

The macrolide antibiotic tylosin is widely used in animal production, but its environmental fate is not fully understood. Objectives of this study were to determine the effect of pH on tylosin A sorption and desorption in three sandy loam soils from Louisiana, USA, that had long histories of poultry waste application, to model sorption and desorption, and to estimate the effect of high soil organic matter on sorption. Twenty-four-hour sorption isotherms (5 to 200 mg L in 0.

Prioritization Approaches for Substances of Emerging Concern in Groundwater: A Critical Review.

Risks from emerging contaminants (ECs) in groundwater to human health and aquatic ecology remain difficult to quantify. The number of ECs potentially found in groundwater presents challenges for regulators and water managers regarding selection for monitoring. This study is the first systematic review of prioritization approaches for selecting ECs that may pose a risk in groundwater.

Failure rates and functional results for intercalary femur reconstructions after tumour resection.

Purpose: To compare the results for patients treated with intercalary endoprosthetic replacement (EPR) or intercalary allograft reconstruction for diaphyseal tumours of the femur in terms of: (1) reconstruction failure rates; (2) cause of failure; (3) risk of amputation of the limb; and (4) functional result.

Methods: Patients with bone sarcomas of the femoral diaphysis, treated with en bloc resection and reconstructed with an intercalary EPR or allograft, were reviewed. A total of 107 patients were included in the study (36 EPR and 71 intercalary allograft reconstruction).

Biochar produced from mineral salt-impregnated chicken manure: Fertility properties and potential for carbon sequestration.

In this study, nutrient properties and carbon sequestration potential of biochars derived from chicken manure (CM) impregnated with mineral salts (calcium chloride, magnesium chloride, ferric chloride) were evaluated. Pretreatment with mineral salts reduced phosphorus (P) availability via the formation of insoluble metal phosphate minerals. Less carbon was lost during the pyrolysis of pretreated CM, and the produced biochars (BC, BC, and BC) were more stable (i.

Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - Multicenter analysis outside clinical trial.

Background: Giant cell tumor of bone (GCTB) is an osteolytic, locally aggressive, rarely metastazing bone tumor. This is a retrospective study evaluating a large series of GCTB patients treated with denosumab in routine practice in 6 European reference centers.

Methods: Patients with locally advanced, unresectable or metastatic GCTB, treated with denosumab outside clinical trials were eligible.

Facilitative capture of As(V), Pb(II) and methylene blue from aqueous solutions with MgO hybrid sponge-like carbonaceous composite derived from sugarcane leafy trash.

Enhancing the contaminant adsorption capacity is a key factor affecting utilization of carbon-based adsorbents in wastewater treatment and encouraging development of biomass thermo-disposal. In this study, a novel MgO hybrid sponge-like carbonaceous composite (HSC) derived from sugarcane leafy trash was prepared through an integrated adsorption-pyrolysis method. The resulted HSC composite was characterized and employed as adsorbent for the removal of negatively charged arsenate (As(V)), positively charged Pb(II), and the organic pollutant methylene blue (MB) from aqueous solutions in batch experiments.

Molecular characterization of a series of 990 index patients with albinism.

Albinism is a clinically and genetically heterogeneous disease characterized by variable degrees of hypopigmentation and by nystagmus, foveal hypoplasia, and chiasmatic misrouting of the optic nerves. The wide phenotypic heterogeneity impedes the establishment of phenotype-genotype correlations. To obtain a precise diagnosis, we screened the 19 known albinism genes in 990 index patients using targeted next-generation sequencing (NGS) and high-resolution comparative genomic hybridization.

Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?

Aims: The aim of this study was to identify any progression between benign osteofibrous dysplasia (OFD), OFD-like adamantinoma and malignant adamantinoma, and to investigate the rates of local recurrence, metastases and survival, in order to develop treatment algorithms for each.

Patients And Methods: A single institution retrospective review of all patients presenting with OFD, OFD-like adamantinoma and adamantinoma between 1973 and 2012 was undertaken. Complete data were available for 73 patients (42 with OFD; ten with an OFD-like adamantinoma and 21 with an adamantinoma).