A trimetallic bismuth(I)-based allyl cation.

The chemistry of low-valent bismuth compounds has recently unlocked new concepts in catalysis and unique electronic structure fundamentals. In this work, we describe the synthesis and characterization of a highly reduced bismuth salt featuring a cationic core based on three contiguous Bi(I) centres. The triatomic bismuth-based core exhibits an electronic configuration that mimics the canonical description of the archetypical carbon-based π-allyl cation.

Imaging Photoplethysmography (iPPG) in Head and Neck Reconstructive Surgery: A Novel Technique for Noninvasive Flap Perfusion Monitoring.

Background: Evaluate imaging photoplethysmography (iPPG) as a novel noninvasive technique to assess flap perfusion in head and neck free flap reconstructive (FFR) surgeries.

Methods: Intraoperative iPPG was performed in 17 patients undergoing FFR surgery. Imaging consisted of a 30-s video from which perfusion maps were extracted, providing detailed information about blood flow and pulsatility in the flap microvasculature.

A Four-Coordinate End-On Superoxocopper(II) Complex: Probing the Link between Coordination Number and Reactivity.

Although the reactivity of five-coordinate end-on superoxocopper(II) complexes, Cu(η-O), is dominated by hydrogen atom transfer, the majority of four-coordinate Cu(η-O) complexes published thus far display nucleophilic reactivity. To investigate the origin of this difference, we have developed a four-coordinate end-on superoxocopper(II) complex supported by a sterically encumbered bis(2-pyridylmethyl)amine ligand, dpb-BPA (), and compared its substrate reactivity with that of a five-coordinate end-on superoxocopper(II) complex ligated by a similarly substituted tris(2-pyridylmethyl)amine, dpb-TMPA (). Kinetic isotope effect (KIE) measurements and correlation of second-order rate constants ('s) versus oxidation potentials () for a range of phenols indicates that the complex [Cu(η-O)()] reacts with phenols via a similar hydrogen atom transfer (HAT) mechanism to [Cu(η-O)()].

Corrigendum to "An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD" [ Volume 9, Issue 2, February 2024, Pages 249-256].

[This corrects the article DOI: 10.1016/j.ekir.

[Risk management with regard to QT-prolonging drugs].

Drug-induced QT prolongation increases the risk of Torsade de Pointes (TdP). Drug-induced QT prolongation is a complex and unpredictable system due to many uncertainties. Risk factors such as electrolyte disturbances, heart failure and genetics play an important role in estimating the effect on QT prolongation.

Molybdenum(VI) Nitrido Complexes with Tripodal Silanolate Ligands. Structure and Electronic Character of an Unsymmetrical Dimolybdenum μ-Nitrido Complex Formed by Incomplete Nitrogen Atom Transfer.

In contrast to a tungsten nitrido complex endowed with a tripodal silanolate ligand framework, which was reported in the literature to be a dimeric species with a metallacyclic core, the corresponding molybdenum nitrides are monomeric entities comprising a regular terminal nitride unit, as proven by single-crystal X-ray diffraction (SC-XRD). Their electronic character is largely determined by the constraints imposed on the metal center by the podand ligand architecture. Mo nuclear magnetic resonance (NMR) and, to a lesser extent, N NMR spectroscopy allow these effects to be studied, which become particularly apparent upon comparison with the spectral data of related molybdenum nitrides comprising unrestrained silanolate, alkoxide, or amide ligands.

Developing a Rehabilitation Guideline (REGUIDE) for Patients Undergoing an Arthroscopic Bankart Repair After Traumatic Anterior Shoulder Dislocation, Focusing on Managing Apprehension: An International Delphi-Based Consensus Study.

We aimed to develop a consensus-based rehabilitation guideline specifically designed to reduce apprehension following arthroscopic Bankart repair after traumatic anterior shoulder dislocation. Delphi-based consensus. A comprehensive list of interventions for potential inclusion in a postoperative rehabilitation guideline was developed.

Validation of the Mayo Imaging Classification System for Predicting Kidney Outcomes in ADPKD.

Background: The Mayo Imaging Classification was developed to predict the rate of disease progression in patients with autosomal dominant polycystic kidney disease. This study aimed to validate its ability to predict kidney outcomes in a large multicenter autosomal dominant polycystic kidney disease cohort.

Methods: Included were patients with ≥1 height-adjusted total kidney volume (HtTKV) measurement and ≥3 eGFR values during ≥1-year follow-up.

An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD.

Introduction: Accurate tools to inform individual prognosis in patients with autosomal dominant polycystic kidney disease (ADPKD) are lacking. Here, we report an artificial intelligence (AI)-generated method for routinely measuring total kidney volume (TKV).

Methods: An ensemble U-net algorithm was created using the nnUNet approach.

Higher beta-hydroxybutyrate ketone levels associated with a slower kidney function decline in ADPKD.

Background: Dysregulated energy metabolism is a recently discovered key feature of autosomal dominant polycystic kidney disease (ADPKD). Cystic cells depend on glucose and are poorly able to use other energy sources such as ketone bodies. Raising ketone body concentration reduced disease progression in animal models of polycystic kidney diseases.

Reactivities and Electronic Structures of μ-1,2-Peroxo and μ-1,2-Superoxo CoCo Complexes: Electrophilic Reactivity and O Release Induced by Oxidation.

Peroxo complexes are key intermediates in water oxidation catalysis (WOC). Cobalt plays an important role in WOC, either as oxides CoO or as {Co(μ1,2-peroxo)Co} complexes, which are the oldest peroxo complexes known. The oxidation of {Co(μ1,2-peroxo)Co} complexes had usually been described to form {Co(μ1,2-superoxo)Co} complexes; however, recently the formation of {Co(μ1,2-peroxo)Co} species were suggested.

Speckle Vibrometry for Instantaneous Heart Rate Monitoring.

Instantaneous heart rate (IHR) has been investigated for sleep applications, such as sleep apnea detection and sleep staging. To ensure the comfort of the patient during sleep, it is desirable for IHR to be measured in a contact-free fashion. In this work, we use speckle vibrometry (SV) to perform on-skin and on-textile IHR monitoring in a sleep setting.

Synthesis and Reactivity of a Cobalt-Supported Singlet Nitrene.

The synthesis, characterization, and reactivity of a series of cobalt terminal imido complexes supported by an -anchored tripodal tris(carbene) chelate is described, including a Co-supported singlet nitrene. Reaction of the Co precursor [(TIMMN)Co](PF) (TIMMN = -[2-(3-mesityl-idazolin-2-ylidene)-ethyl]amie) with -methoxyphenyl azide yields a Co imide [(TIMMN)Co(NAnisole)](PF) (). Treatment of with 1 equiv of [FeCp](PF) at -35 °C affords a formal Co imido complex [(TIMMN)Co(NAnisole)](PF) (), which features a bent Co-N(imido)-C(Anisole) linkage.

Synthesis and isolation of a triplet bismuthinidene with a quenched magnetic response.

Large spin-orbit coupling (SOC) is an intrinsic property of the heavy elements that directly affects the electronic structures of the compounds. In this work, we report the synthesis and characterization of a monocoordinate bismuthinidene that features a rigid and bulky ligand. All magnetic measurements [superconducting quantum interference device (SQUID), nuclear magnetic resonance (NMR)] point to a diamagnetic compound.

Contactless Camera-Based Sleep Staging: The HealthBed Study.

Polysomnography (PSG) remains the gold standard for sleep monitoring but is obtrusive in nature. Advances in camera sensor technology and data analysis techniques enable contactless monitoring of heart rate variability (HRV). In turn, this may allow remote assessment of sleep stages, as different HRV metrics indirectly reflect the expression of sleep stages.

Validation of a semi-automatic method to measure total liver volumes in polycystic liver disease on computed tomography - high speed and accuracy.

Objectives: Polycystic liver disease (PLD) is characterized by growth of hepatic cysts, causing hepatomegaly. Disease severity is determined using total liver volume (TLV), which can be measured from computed tomography (CT). The gold standard is manual segmentation which is time-consuming and requires expert knowledge of the anatomy.

Automated Kidney and Liver Segmentation in MR Images in Patients with Autosomal Dominant Polycystic Kidney Disease: A Multicenter Study.

Background: Imaging-based total kidney volume (TKV) and total liver volume (TLV) are major prognostic factors in autosomal dominant polycystic kidney disease (ADPKD) and end points for clinical trials. However, volumetry is time consuming and reader dependent in clinical practice. Our aim was to develop a fully automated method for joint kidney and liver segmentation in magnetic resonance imaging (MRI) and to evaluate its performance in a multisequence, multicenter setting.

Contactless SpO with an RGB camera: experimental proof of calibrated SpO.

Camera-based blood oxygen saturation (SpO) monitoring allows reliable measurements without touching the skin and is therefore very attractive when there is a risk of cross-infection, in case of fragile skin, and/or to improve the clinical workflow. Despite promising results, productization of the technology is hampered by the unavailability of adequate hardware, especially a camera, which can capture the optimal wavelengths for SpO measurements in the red near-infrared region. A regular color (RGB) camera is attractive because of its availability, but also poses several risks and challenges which affect the accuracy of the measurement.

Imaging Photoplethysmography for Noninvasive Anastomotic Perfusion Assessment in Intestinal Surgery.

Introduction: Anastomotic leakage after gastrointestinal surgery has a high impact on patient's quality of life and its origin is associated with inadequate perfusion. Imaging photoplethysmography (iPPG) is a noninvasive imaging technique that measures blood-volume changes in the microvascular tissue bed and detects changes in tissue perfusion.

Materials And Methods: Intraoperative iPPG imaging was performed in 29 patients undergoing an open segment resection of the small intestine or colon.

Crystalline Anions Based on Classical N-Heterocyclic Carbenes.

Herein, the first stable anions K[SIPr ] (4 a-K) and K[IPr ] (4 b-K) (SIPr =BpC{N(Dipp)CH } , IPr =BpC{N(Dipp)CH} ; Bp=4-PhC H ; Dipp=2,6-iPr C H ) derived from classical N-heterocyclic carbenes (NHCs) (i.e. SIPr and IPr) have been isolated as violet crystalline solids.

Contactless Heartbeat Measurement Using Speckle Vibrometry.

Monitoring of heart rate in patients in the general ward is necessary to assess the clinical situation of the patient. Currently, this is done via spot-checks on pulse rate manually or on heart rate using Electrocardiogram (ECG) by nurses. More frequent measurements would allow early detection of adverse cardiac events.

Umpolung in a Pair of Cobalt(III) Terminal Imido/Imidyl Complexes.

Reaction of the Co complex [(TIMMN )Co ](PF ) (1) (TIMMN =tris-[2-(3-mesityl-imidazolin-2-ylidene)-methyl]amine) with mesityl azide yields the Co imide [(TIMMN )Co (NMes)](PF ) (2). Oxidation of 2 with [FeCp ](PF ) provides access to a rare Co imidyl [(TIMMN )Co(NMes)](PF ) (3). Single-crystal X-ray diffractometry and EPR spectroscopy confirm the molecular structure of 3 and its S= ground state.

Imaging PPG for In Vivo Human Tissue Perfusion Assessment during Surgery.

Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues.

Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.

Background And Objectives: The vasopressin V2 receptor antagonist tolvaptan is the only drug that has been proven to be nephroprotective in autosomal dominant polycystic kidney disease (ADPKD). Tolvaptan also causes polyuria, limiting tolerability. We hypothesized that cotreatment with hydrochlorothiazide or metformin may ameliorate this side effect.